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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 670-6B
  • locus tag: SP670_RS05715 [old locus tag: SP670_1154 ]
  • pan locus tag?: PNEUPAN000861000
  • symbol: SP670_RS05715
  • pan gene symbol?: —
  • synonym:
  • product: sigma-70 family RNA polymerase sigma factor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP670_RS05715 [old locus tag: SP670_1154 ]
  • symbol: SP670_RS05715
  • product: sigma-70 family RNA polymerase sigma factor
  • replicon: chromosome
  • strand: -
  • coordinates: 1072698..1073120
  • length: 423
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014498 (1072698..1073120) NCBI
  • BioCyc: SP670_RS05715 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGAAACCATCTTCTTTTCAGACCACAATAGAAAATCAGTTTGACTATATCTGTAAACGT
    GCTATGGAAGACGAGCGAAAGAATTATATGCTTTATCTTTCAAGGATTGCAAAGCGTGAG
    GTGTCCTTTTCGGATGTTGGCGATTATCTTGTTAGCCAGTTTGCGACAACAGATAACTAT
    TCAACTGACTTTCAGATTTTTACACTCAATGGGTTATCAGTAGGCGTTGAAAATGATTTG
    TTGAGTGAAGCATTACGTGAGTTGCCAGACAAGAAACGTGAAATTCTACTGCTGTTTTAC
    TTTATGGACATGAGCGATTCAGAAATTGCAGACCTGTTGAAATTGAACCGTTCTACTGTC
    TATCGGCATAGAACCAGTGGACTAGCCTTAATTAAAAAGTTTATGGAGGAATTTGAAGAA
    TGA
    60
    120
    180
    240
    300
    360
    420
    423

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP670_RS05715 [old locus tag: SP670_1154 ]
  • symbol: SP670_RS05715
  • description: sigma-70 family RNA polymerase sigma factor
  • length: 140
  • theoretical pI: 4.60339
  • theoretical MW: 16460.6
  • GRAVY: -0.383571

⊟Function[edit | edit source]

  • TIGRFAM:
    RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 45.9)
    RNA polymerase sigma-70 factor, Bacteroides expansion family 1 (TIGR02985; HMM-score: 39.3)
    RNA polymerase sigma-70 factor, sigma-E family (TIGR02983; HMM-score: 37.3)
    and 16 more
    RNA polymerase sigma-70 factor, TIGR02954 family (TIGR02954; HMM-score: 29.9)
    RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1 (TIGR02984; HMM-score: 28.4)
    RNA polymerase sigma-70 factor, Myxococcales family 1 (TIGR03001; HMM-score: 26.2)
    RNA polymerase sigma-70 factor, sigma-B/F/G subfamily (TIGR02980; HMM-score: 25.8)
    RNA polymerase sigma-W factor (TIGR02948; HMM-score: 25.1)
    RNA polymerase sigma factor, FliA/WhiG family (TIGR02479; HMM-score: 23.3)
    RNA polymerase sigma factor, SigM family (TIGR02950; HMM-score: 21.9)
    Cellular processes Cellular processes Sporulation and germination RNA polymerase sigma-E factor (TIGR02835; HMM-score: 21.1)
    Genetic information processing Transcription Transcription factors RNA polymerase sigma-E factor (TIGR02835; HMM-score: 21.1)
    transcriptional regulator BotR, P-21 (TIGR03209; HMM-score: 20.8)
    Cellular processes Cellular processes Sporulation and germination RNA polymerase sigma-F factor (TIGR02885; HMM-score: 20.3)
    Genetic information processing Transcription Transcription factors RNA polymerase sigma-F factor (TIGR02885; HMM-score: 20.3)
    RNA polymerase sigma factor, TIGR02999 family (TIGR02999; HMM-score: 19.9)
    RNA polymerase sigma-70 factor, TIGR02952 family (TIGR02952; HMM-score: 15)
    RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family (TIGR02989; HMM-score: 13.8)
    RNA polymerase sigma factor, SigZ family (TIGR02959; HMM-score: 13.2)
  • TheSEED: see SP670_1154
  • PFAM:
    HTH (CL0123) Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 41.2)
    and 12 more
    Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 30.5)
    UPF0122; Putative helix-turn-helix protein, YlxM / p13 like (PF04297; HMM-score: 22.9)
    HTH_23; Homeodomain-like domain (PF13384; HMM-score: 20.5)
    HTH_17; Helix-turn-helix domain (PF12728; HMM-score: 17.5)
    Xre-like-HTH; Antitoxin Xre-like helix-turn-helix domain (PF20432; HMM-score: 16)
    HTH_5; Bacterial regulatory protein, arsR family (PF01022; HMM-score: 15.9)
    HTH_38; Helix-turn-helix domain (PF13936; HMM-score: 15.3)
    HTH_IclR; IclR helix-turn-helix domain (PF09339; HMM-score: 14.7)
    HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 13.6)
    DUF1492; Protein of unknown function (DUF1492) (PF07374; HMM-score: 13.5)
    Terminase_5; Putative ATPase subunit of terminase (gpP-like) (PF06056; HMM-score: 13.1)
    HTH_7; Helix-turn-helix domain of resolvase (PF02796; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9153
    • Cytoplasmic Membrane Score: 0.0651
    • Cell wall & surface Score: 0.0018
    • Extracellular Score: 0.0178
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00635
    • TAT(Tat/SPI): 0.000519
    • LIPO(Sec/SPII): 0.000832
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000804885 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKPSSFQTTIENQFDYICKRAMEDERKNYMLYLSRIAKREVSFSDVGDYLVSQFATTDNYSTDFQIFTLNGLSVGVENDLLSEALRELPDKKREILLLFYFMDMSDSEIADLLKLNRSTVYRHRTSGLALIKKFMEEFEE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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