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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_0124 [new locus tag: SP70585_RS00610 ]
  • pan locus tag?: PNEUPAN000704000
  • symbol: SP70585_0124
  • pan gene symbol?: strH
  • synonym:
  • product: beta-N-acetylhexosaminidase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_0124 [new locus tag: SP70585_RS00610 ]
  • symbol: SP70585_0124
  • product: beta-N-acetylhexosaminidase
  • replicon: chromosome
  • strand: -
  • coordinates: 101845..105807
  • length: 3963
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    3661
    3721
    3781
    3841
    3901
    3961
    ATGAAACATGAAAAACAACAGCGTTTTTCTATTCGTAAATACGCTGTAGGAGCAGCTTCT
    GTTCTAATTGGATTTGCCTTCCAAGCACAGACTGTTGCAGCCGATGGAGTTACTCCTACT
    ACTACAGAAAACCAACCGACCATCCATACGGTTTCTGATTCCCCTCAATCATCCGAAAAT
    CGGACTGAGGAAACACCTAAAGCAGAGCTTCAACCAGAAGCTCCAAAAACTGTAGAAACA
    GAAGCTCCAAAAACTGTAGAAACAGAAACTCCAGCTACTGATAAGGTAGCTAGTCTTCCA
    AAAACAGAAGAAAAACCACAAGAGGAAGTTAGTTCAACTCCTAGTGATAAAGCAGAGGTG
    GTAACTCCAACTTCTGCTGAAAAAGAAACTGCTAATAAAAAGGAAGAAGAAGCTAGCCCT
    AAAAAGGAAGAAGCGAAAGAGGTTGATTCTAAAGAGTCAAATACAGACAAGACTGACAAG
    GATAAACCAGCTAAAAAAGATGAAGCGAAAGCAGAGGCTGACAAACCGGAAACAGAGACA
    GGAAAGGAACGTGCTGCAACTGTAAATGAAAAACTAGCGAAAAAGAAAATTGTTTCTATT
    GATGCTGGACGTAAATATTTCTCACCAGAACAGCTCAAGGAAATCATCGATAAAGCGAAA
    CATTATGGCTACACTGATTTACACCTATTAGTCGGAAATGATGGACTCCGTTTCATGTTG
    GACGATATGAGCATCACAGCTAACGGCAAGACCTATGCCAGTGACGATGTCAAACGCGCC
    ATTGAAAAAGGTACAAATGATTATTACAACGATCCAAACGGCAATCACTTAACAGAAAGT
    CAAATGACAGATCTGATTAACTATGCCAAAGATAAAGGTATCGGTCTCATTCCGACAGTA
    AATAGTCCTGGACACATGGATGCGATTCTCAATGCCATGAAAGAATTGGGAATCCAAAAC
    CCTAACTTTAGCTATTTTGGGAAGAAATCAGCCCGTACTGTCGATCTTGACAACGAACAA
    GCTGTCGCTTTTACAAAAGCCCTTATCGACAAGTATGCTGCTTATTTCGCGAAAAAGACT
    GAAATCTTCAACATCGGACTTGATGAATATGCCAATGATGCGACAGATGCTAAAGGTTGG
    AGTGTGCTTCAAGCTGATAAATACTATCCAAACGAAGGCTACCCTGTAAAAGGCTATGAA
    AAATTTATTGCCTACGCCAATGACCTCGCTCGTATTGTAAAATCGCACGGTCTCAAACCA
    ATGGCCTTTAACGACGGTATCTACTACAATAGCGACACAAGCTTTGGTAGTTTTGACAAA
    GACATCATCGTTTCTATGTGGACTGGTGGTTGGGGAGGCTACGATGTCGCTTCTTCTAAA
    CTACTAGCTGAAAAAGGTCACCAAATCCTTAATACCAATGATGCTTGGTACTACGTTCTT
    GGACGAAACGCTGATGGCCAAGGCTGGTACAATCTCGATCAGGGGCTCAATGGTATTAAA
    AACACACCAATCACTTCTGTACCAAAAACAGAAGGAGCTGATATCCCAATCATCGGTGGT
    ATGGTAGCTGCTTGGGCTGACACTCCATCTGCACGTTATTCACCATCACGCCTCTTCAAA
    CTCATGCGTCATTTTGCAAATGCCAACGCTGAATACTTCGCAGCTGATTATGAATCTGCA
    GAGCAAGCACTTAACGAGGTACCAAAAGACCTGAACCGTTATACTGCAGAAAGCGTCGCG
    GCCGTAAAAGAAGCTGAAAAAGCTATTCGCTCTCTCGATAGCAACCTTAGCCGTGCCCAA
    CAAGATACGATTGATCAAGCCATTGCTAAACTTCAAGAAACTGTCAACAACTTGACCCTC
    ACGCCTGAAGCTCAAAAAGAAGAAGAAGCTAAACGTGAGGTTGAAAAACTTGCCAAAAAC
    AAGGTAATCTCAATCGATGCTGGACGCAAATACTTTACTCTGAACCAGCTCAAACGCATC
    GTAGACAAGGCCAGTGAGCTCGGATATTCTGATGTCCATCTCCTTCTAGGAAATGACGGA
    CTTCGCTTTCTACTCGATGATATGACCATTACTGCCAACGGAAAAACCTATGCTAGTGAT
    GACGTTAAAAAAGCTATTATCGAAGGAACTAAAGCTTACTACGACGATCCAAACGGTACT
    GCACTAACACAGGCAGAAGTGACAGAGCTAATTGAATACGCTAAATCTAAGGACATCGGT
    CTCATCCCAGCTATTAACAGTCCAGGTCACATGGATGCTATGCTGGTTGCCATGGAAAAA
    TTAGGTATTAAAAATCCTCAAGCCCACTTTGATAAAGTTTCAAAAACAACTATGGACTTG
    AAAAACGAAGAAGCGATGAACTTTGTAAAAGCCCTCATCGGTAAATACATGGACTTCTTT
    GCAGGTAAAACAAAGATTTTCAACTTTGGTACTGACGAATACGCCAACGATGCGACTAGT
    GCCCAAGGCTGGTACTACCTCAAGTGGTATCAACTCTATGGCAAATTTGCCGAATATGCC
    AACACCCTCGCAGCTATGGCCAAAGAAAGAGGGCTTCAACCAATGGCCTTCAACGATGGC
    TTCTACTATGAAGACAAGGACGATGTTCAGTTTGACAAAGATGTCTTGATTTCTTACTGG
    TCTAAAGGCTGGTGGGGATATAACCTCGCATCACCTCAATACCTAGCAAGCAAAGGCTAT
    AAATTCTTGAATACCAACGGTGACTGGTACTACATTCTTGGTCAAAAACCAGAAGATGGT
    GGTGGTTTCCTCAAGAAAGCTATTGAGAATACTGGAAAAACACCATTCAATCAACTAGCT
    TCTACCAAATATCCTGAAGTAGATCTTCCAACAGTCGGAAGTATGCTTTCAATCTGGGCA
    GATAGACCAAGCGCTGAGTACAAGGAAGAGGAAATCTTTGAACTCATGACTGCCTTTGCA
    GACCACAACAAAGACTACTTCCGTGCTAATTATAATGCTCTCCGCGAAGAATTAGCTAAA
    ATTCCTACAAACTTAGAAGGATATAGTAAAGAAAGTCTTGAGGCCCTTGACGCAGCTAAA
    ACAGCTCTAAATTACAACCTCAACCGTAATAAACAAGCTGAGCTTGACACACTTGTAGCC
    AACCTAAAAGCCGCTCTTCAAGGCCTCAAACCAGCTGCAACTCATTCAGGAAGCCTAGAT
    GAAAATGAAGTGGCTGCCAATGTTGAAACCAGACCAGAACTCATCACAAGAACTGAAGAA
    ATTCCATTTGAAGTTATCAAGAAAGAAAATCCTAACCTCCCAGCTGGTCAGGAAAATATT
    ATCACAGCAGGAGTCAAAGGTGAACGAACTCATTACATCTCTGTACTCACTGAAAATGGA
    AAAACAACAGAAACAGTCCTTGATAGCCAGGTAACCAAAGAAGTTATAAACCAAGTGGTT
    GAAGTTGGCTCTCCTGTAACTCACAAGGGTGATGAAAGTGGTCTTGCACCAACTACTGAG
    GTAAAACCTAGACTGGATATCCAAGAAGAAGAAATTCCATTTACCACAGTGACTCGTGAA
    AATCCACTCTTACTCAAAGGAAAAACACAAGTCATTACTAAGGGCGTCAATGGACATCGT
    AGCAACTTCTACTCTGTGAGCACTTCTGCCGATGGTAAGGAAGTGAAAACACTTGTAAAT
    AGTGTCGTAGCACAGGAAGCCGTTACTCAAATAGTCGAAGTCGGAACTATGGTAACACAT
    GTAGGCGATGAAAACGGACAAGCCGCTATTGCTGAAGAAAAACCAAAACTAGAAATCCCA
    AGCCAACCAGCTCCATCAACTGCTCCTGCTGAGGAAAGCAAAGCTCTTCCTCAAGATCCA
    GCTCCTGTGGTAACAGAGAAAAAACTTCCTGAAACAGGAACTCACGATTCTGCAGGACTA
    GTAGTCGCAGGACTCATGTCCACACTAGCAGCCTATGGACTCACTAAAAGAAAAGAAGAC
    TAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3240
    3300
    3360
    3420
    3480
    3540
    3600
    3660
    3720
    3780
    3840
    3900
    3960
    3963

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP70585_0124 [new locus tag: SP70585_RS00610 ]
  • symbol: SP70585_0124
  • description: beta-N-acetylhexosaminidase
  • length: 1320
  • theoretical pI: 4.84385
  • theoretical MW: 145564
  • GRAVY: -0.594924

⊟Function[edit | edit source]

  • reaction:
    EC 3.2.1.52?  ExPASy
    Beta-N-acetylhexosaminidase Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
  • TIGRFAM:
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 48.3)
    and 6 more
    Genetic information processing Protein synthesis tRNA and rRNA base modification rRNA large subunit m3Psi methyltransferase RlmH (TIGR00246; EC 2.1.1.177; HMM-score: 23.7)
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 22.6)
    LL-diaminopimelate aminotransferase (TIGR03542; EC 2.6.1.83; HMM-score: 14.5)
    undecaprenyl-phosphate glucose phosphotransferase (TIGR03023; EC 2.7.8.-; HMM-score: 13.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin heme b synthase (TIGR04545; EC 1.3.99.-; HMM-score: 12.7)
    Metabolism Energy metabolism Photosynthesis photosystem II protein PsbQ (TIGR03042; HMM-score: 6.2)
  • TheSEED  :
    • Beta-hexosaminidase (EC 3.2.1.52)
    Carbohydrates Aminosugars N-Acetyl-Galactosamine and Galactosamine Utilization  Beta-hexosaminidase (EC 3.2.1.52)
    and 1 more
    Nucleosides and Nucleotides Purines Purine Utilization  Beta-hexosaminidase (EC 3.2.1.52)
  • PFAM:
    Glyco_hydro_tim (CL0058) Glyco_hydro_20; Glycosyl hydrolase family 20, catalytic domain (PF00728; HMM-score: 170)
    and 8 more
    G5 (CL0593) G5; G5 domain (PF07501; HMM-score: 100.1)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 38.9)
    Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 28.5)
    DUF6437; Family of unknown function (DUF6437) (PF20031; HMM-score: 16.4)
    HemX; HemX, putative uroporphyrinogen-III C-methyltransferase (PF04375; HMM-score: 16.2)
    Baculo_PEP_C; Baculovirus polyhedron envelope protein, PEP, C terminus (PF04513; HMM-score: 13.2)
    SPOUT (CL0098) SPOUT_MTase; Predicted SPOUT methyltransferase (PF02590; HMM-score: 10.6)
    no clan defined FancD2; Fanconi anaemia protein FancD2 nuclease (PF14631; HMM-score: 7.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 0
  • SignalP: Signal peptide SP(Sec/SPI) length 34 aa
    • SP(Sec/SPI): 0.96522
    • TAT(Tat/SPI): 0.022868
    • LIPO(Sec/SPII): 0.005032
    • Cleavage Site: CS pos: 34-35. VAA-DG. Pr: 0.5515
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKHEKQQRFSIRKYAVGAASVLIGFAFQAQTVAADGVTPTTTENQPTIHTVSDSPQSSENRTEETPKAELQPEAPKTVETEAPKTVETETPATDKVASLPKTEEKPQEEVSSTPSDKAEVVTPTSAEKETANKKEEEASPKKEEAKEVDSKESNTDKTDKDKPAKKDEAKAEADKPETETGKERAATVNEKLAKKKIVSIDAGRKYFSPEQLKEIIDKAKHYGYTDLHLLVGNDGLRFMLDDMSITANGKTYASDDVKRAIEKGTNDYYNDPNGNHLTESQMTDLINYAKDKGIGLIPTVNSPGHMDAILNAMKELGIQNPNFSYFGKKSARTVDLDNEQAVAFTKALIDKYAAYFAKKTEIFNIGLDEYANDATDAKGWSVLQADKYYPNEGYPVKGYEKFIAYANDLARIVKSHGLKPMAFNDGIYYNSDTSFGSFDKDIIVSMWTGGWGGYDVASSKLLAEKGHQILNTNDAWYYVLGRNADGQGWYNLDQGLNGIKNTPITSVPKTEGADIPIIGGMVAAWADTPSARYSPSRLFKLMRHFANANAEYFAADYESAEQALNEVPKDLNRYTAESVAAVKEAEKAIRSLDSNLSRAQQDTIDQAIAKLQETVNNLTLTPEAQKEEEAKREVEKLAKNKVISIDAGRKYFTLNQLKRIVDKASELGYSDVHLLLGNDGLRFLLDDMTITANGKTYASDDVKKAIIEGTKAYYDDPNGTALTQAEVTELIEYAKSKDIGLIPAINSPGHMDAMLVAMEKLGIKNPQAHFDKVSKTTMDLKNEEAMNFVKALIGKYMDFFAGKTKIFNFGTDEYANDATSAQGWYYLKWYQLYGKFAEYANTLAAMAKERGLQPMAFNDGFYYEDKDDVQFDKDVLISYWSKGWWGYNLASPQYLASKGYKFLNTNGDWYYILGQKPEDGGGFLKKAIENTGKTPFNQLASTKYPEVDLPTVGSMLSIWADRPSAEYKEEEIFELMTAFADHNKDYFRANYNALREELAKIPTNLEGYSKESLEALDAAKTALNYNLNRNKQAELDTLVANLKAALQGLKPAATHSGSLDENEVAANVETRPELITRTEEIPFEVIKKENPNLPAGQENIITAGVKGERTHYISVLTENGKTTETVLDSQVTKEVINQVVEVGSPVTHKGDESGLAPTTEVKPRLDIQEEEIPFTTVTRENPLLLKGKTQVITKGVNGHRSNFYSVSTSADGKEVKTLVNSVVAQEAVTQIVEVGTMVTHVGDENGQAAIAEEKPKLEIPSQPAPSTAPAEESKALPQDPAPVVTEKKLPETGTHDSAGLVVAGLMSTLAAYGLTKRKED

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Ankur B Dalia, Alistair J Standish, Jeffrey N Weiser
Three surface exoglycosidases from Streptococcus pneumoniae, NanA, BgaA, and StrH, promote resistance to opsonophagocytic killing by human neutrophils.
Infect Immun: 2010, 78(5);2108-16
[PubMed:20160017] [WorldCat.org] [DOI] (I p)

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