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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_0426 [new locus tag: SP70585_RS02090 ]
  • pan locus tag?: PNEUPAN001179000
  • symbol: SP70585_0426
  • pan gene symbol?: cps4K
  • synonym:
  • product: UDP-2-acetamido-2,6-dideoxy-b-L-lyxo-4-hexulose 4-reductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_0426 [new locus tag: SP70585_RS02090 ]
  • symbol: SP70585_0426
  • product: UDP-2-acetamido-2,6-dideoxy-b-L-lyxo-4-hexulose 4-reductase
  • replicon: chromosome
  • strand: +
  • coordinates: 377894..379123
  • length: 1230
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGCCATTAAAAATTTTAGTGACTGGTTCTAAAGGATTTGTAGGAAAAAATCTTATCTGT
    ACTCTGGAAGCTTTGAAAGATGGACGAGATAGGACTCGTCCTAATTTAGAGATTGGAGAG
    ATTTTTCAGTATGATCGTGATACAGATCCGATTTTATTAGATGAATATTGTAAGAAGGCC
    GATTTCGTATTCCATTTAGCTGGTGTCAATCGTCCACAGAATCCTGATGAATTCATGGAG
    GGAAATTACGGTTTTTCAAGTAGATTATTGGAGATTTTAGAAAAGTATGAAAACACTTGT
    CCTGTTCTACTCTCAAGTTCTACTCAAGCTAGTTTAGAAGGCCGATTTTCAAACTCTATA
    TATGGACAATCTAAGCTAGTAGGGGAAGAACTCTTCTTTGAATATGGAAAGAAAACGGGA
    GCACCTGTCTTAGTTTACCGTTTCCCGAATCTTTATGGGAAGTGGTGCCGTCCTAACTAC
    AATTCTGCTGTAGCAACTTTCTGTCATAATCTAGCTCACGATTTACCTATTCAAGTAAAT
    GATCCAAGTGTAGAATTGGAGTTGCTGTATATTGATGATTTGATACAAGAGTGTCTAACT
    GCATTGGAAGGAAATCCTCATCGTTGTAATCTAGATGGATTACAAATCTTACCTAGCCCA
    TCAGGAAACTACTGCTACGTACCAACGACTCATCGTGCAACCTTAGGAGAGATTGTCTCT
    CTATTAGAAACATTTAAAAAACAGCCTAATAGTTTAGTTATGCCTGAAATTCCTCAAGGA
    TCGTTTAAAAAGAAATTGTATTCTACCTACCTATCTTATTTACCAGTAGATAAGTTTAAG
    TTTCCTCTAAAAATGAATATAGATGAACGAGGTAGTTTTACGGAATTATTAAAAACAGAA
    AATAAGGGTCAATTTTCTGTTAATATTTCTAAACCTGGCATTACCAAAGGGCAACATTGG
    CATCATTCTAAGTGGGAATTTTTCATGGTTGTTTCTGGTCGTGCTTTAATACAAGAGCGT
    AGGATAGGGCTGGATGAAAACGGTCAAGAGTATCCTATTCTGAACTTTGAAGTGTCGGGC
    GATAAGATTGAAGCAATACATATGATACCGGGCTATGCACATAATATTATTAATCTTTCT
    GATACAGAAAATCTAGTTACTGTCATGTGGGCTAATGAGTCATTTGATCCTAGACATCCA
    GATACTTTTTTTGAACAAGTGGAGAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1230

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP70585_0426 [new locus tag: SP70585_RS02090 ]
  • symbol: SP70585_0426
  • description: UDP-2-acetamido-2,6-dideoxy-b-L-lyxo-4-hexulose 4-reductase
  • length: 409
  • theoretical pI: 5.63012
  • theoretical MW: 46596.8
  • GRAVY: -0.363814

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides ADP-glyceromanno-heptose 6-epimerase (TIGR02197; EC 5.1.3.20; HMM-score: 24.6)
    cupin fold metalloprotein, WbuC family (TIGR04366; HMM-score: 21.2)
    and 5 more
    thioester reductase domain (TIGR01746; HMM-score: 16)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides dTDP-4-dehydrorhamnose reductase (TIGR01214; EC 1.1.1.133; HMM-score: 15.8)
    Hypothetical proteins Conserved TIGR01777 family protein (TIGR01777; HMM-score: 12.5)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides dTDP-glucose 4,6-dehydratase (TIGR01181; EC 4.2.1.46; HMM-score: 12.3)
    hopanoid-associated sugar epimerase (TIGR03466; HMM-score: 10.8)
  • TheSEED  :
    • Capsular polysaccharide synthesis enzyme Cap5F
  • PFAM:
    NADP_Rossmann (CL0063) Epimerase; NAD dependent epimerase/dehydratase family (PF01370; HMM-score: 60.1)
    and 5 more
    NAD_binding_4; Male sterility protein (PF07993; HMM-score: 25.5)
    Cupin (CL0029) Cupin_2; Cupin domain (PF07883; HMM-score: 17.3)
    NADP_Rossmann (CL0063) RmlD_sub_bind; RmlD substrate binding domain (PF04321; HMM-score: 16.8)
    GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase (PF16363; HMM-score: 15.7)
    Cupin (CL0029) FdtA; WxcM-like, C-terminal (PF05523; HMM-score: 12.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.878
    • Cytoplasmic Membrane Score: 0.0193
    • Cell wall & surface Score: 0.0013
    • Extracellular Score: 0.1013
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006988
    • TAT(Tat/SPI): 0.000201
    • LIPO(Sec/SPII): 0.002505
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MPLKILVTGSKGFVGKNLICTLEALKDGRDRTRPNLEIGEIFQYDRDTDPILLDEYCKKADFVFHLAGVNRPQNPDEFMEGNYGFSSRLLEILEKYENTCPVLLSSSTQASLEGRFSNSIYGQSKLVGEELFFEYGKKTGAPVLVYRFPNLYGKWCRPNYNSAVATFCHNLAHDLPIQVNDPSVELELLYIDDLIQECLTALEGNPHRCNLDGLQILPSPSGNYCYVPTTHRATLGEIVSLLETFKKQPNSLVMPEIPQGSFKKKLYSTYLSYLPVDKFKFPLKMNIDERGSFTELLKTENKGQFSVNISKPGITKGQHWHHSKWEFFMVVSGRALIQERRIGLDENGQEYPILNFEVSGDKIEAIHMIPGYAHNIINLSDTENLVTVMWANESFDPRHPDTFFEQVEK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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