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serotype 5
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serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_0425 [new locus tag: SP70585_RS02085 ]
  • pan locus tag?: PNEUPAN001151000
  • symbol: ugd
  • pan gene symbol?: cps2K
  • synonym:
  • product: UDP-glucose 6-dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_0425 [new locus tag: SP70585_RS02085 ]
  • symbol: ugd
  • product: UDP-glucose 6-dehydrogenase
  • replicon: chromosome
  • strand: +
  • coordinates: 376664..377875
  • length: 1212
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGAAAATAGCAGTAGCAGGGACAGGTTATGTGGGTTTATCTATTGCAATTCTATTAGCG
    CAATATCATAAGGTTATGGCGGTAGATGTTATTCCTGAAAAAGTAGAGCTTATCAATCGT
    CGCCAATCTCCCATTAAGGATGATGATATTGAAACTTATTTAGTGGAAAAGGAATTAGAC
    TTAGTTGCAACATTAGATGGTAATGAAGCTTATCGAGATGCTGACTTTGTCATAATTGCT
    GTCCCAACTAACTATGACAGTAAAAAAAATTATTTTGATACATCTGTTGTGGAAGCAGTT
    ATTGAGCAGATTATTGCGGTTAATTTGAAGGCAACAATTGTCATAAAATCCACAATTCCT
    GTGGGATATACAGAAAGTCTCCGAACACGTTTTGGGCAATTTAAGATTCTCTTTAGTCCT
    GAATTTTTACGGGAGTCTAAAGCACTTTATGATAATCTCTATCCTAGTCGAATCATCGTT
    GGAGCAGATTTGAGAGATACGGAGCAGGTAGTTCAGGCTGAGCGGTTTGCAACTCTTTTG
    CAGGAAGGTTCACTTAAACCTGATGTTGAGACCTTAATTATGGGTGTAACAGAGGCAGAA
    GCAGTCAAACTATTTGCCAACACCTATTTGGCTTTGCGGGTTTCTTACTTTAACGAATTG
    GATACCTATGCGGAGATAAAGGGATTGGACACTAAATCCATCATTGACGGAGTAGGGTTA
    GATCCACGAATTGGTAGCCATTATAACAATCCGTCATTTGGTTATGGAGGTTATTGTCTT
    CCCAAAGATAGTAAGCAGTTGCTGGCGAATTATCATGATGTACCACAAAATATGATGACA
    GCTATTGTAGAAAGTAACCGTACTCGCAAGTATTTTATTGCCGATCGTATTTTGAAAAAT
    GCGTTGGAGCTTTCAGACGGTAATCAAACAATCATAGTAGGTGTTTACCGCTTAACTATG
    AAGAGTGGTTCGGATAATTTCCGTCAATCATCAATCCAAGGTGTTATAAAATGTTTAAAG
    GCCAAAGGTGTAGAAGTAATTATCTATGAACCAACTTTGGAGGATCATAGCTTTTTCTTT
    GGTAATCAGGTGGTTAATGATTTGGAAGTTTTTAAGTCTAGCAGTCAAGTGATTGTTGCC
    AATCGGATGGAAAAATCTTTATATGATGTGCTAGAAAAAGTTTATACAAGAGATATTTTT
    CAGCGAGATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1212

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP70585_0425 [new locus tag: SP70585_RS02085 ]
  • symbol: Ugd
  • description: UDP-glucose 6-dehydrogenase
  • length: 403
  • theoretical pI: 4.91462
  • theoretical MW: 45347.6
  • GRAVY: -0.0868486

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.22?  ExPASy
    UDP-glucose 6-dehydrogenase UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH
  • TIGRFAM:
    nucleotide sugar dehydrogenase (TIGR03026; HMM-score: 320.3)
    and 2 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A 2-dehydropantoate 2-reductase (TIGR00745; EC 1.1.1.-; HMM-score: 12.4)
    3-hydroxyacyl-CoA dehydrogenase PaaC (TIGR02279; EC 1.1.1.-; HMM-score: 11)
  • TheSEED  :
    • UDP-glucose dehydrogenase (EC 1.1.1.22)
    Cell Wall and Capsule Capsular and extracellular polysacchrides Streptococcal Hyaluronic Acid Capsule  UDP-glucose dehydrogenase (EC 1.1.1.22)
  • PFAM:
    NADP_Rossmann (CL0063) UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain (PF03721; HMM-score: 121.1)
    and 10 more
    6PGD_C (CL0106) UDPG_MGDP_dh; UDP-glucose/GDP-mannose dehydrogenase family, central domain (PF00984; HMM-score: 91)
    HUP (CL0039) UDPG_MGDP_dh_C; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain (PF03720; HMM-score: 33.5)
    NADP_Rossmann (CL0063) 3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 30)
    NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus (PF01210; HMM-score: 24.4)
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 21.1)
    2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 17.5)
    ApbA; Ketopantoate reductase PanE/ApbA (PF02558; HMM-score: 17.1)
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 16.6)
    TrkA_N; TrkA-N domain (PF02254; HMM-score: 16.1)
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase (PF03446; HMM-score: 15.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9852
    • Cytoplasmic Membrane Score: 0.0056
    • Cell wall & surface Score: 0.001
    • Extracellular Score: 0.0083
  • SignalP: Signal peptide SP(Sec/SPI) length 27 aa
    • SP(Sec/SPI): 0.85488
    • TAT(Tat/SPI): 0.001598
    • LIPO(Sec/SPII): 0.006386
    • Cleavage Site: CS pos: 27-28. VMA-VD. Pr: 0.8378
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKIAVAGTGYVGLSIAILLAQYHKVMAVDVIPEKVELINRRQSPIKDDDIETYLVEKELDLVATLDGNEAYRDADFVIIAVPTNYDSKKNYFDTSVVEAVIEQIIAVNLKATIVIKSTIPVGYTESLRTRFGQFKILFSPEFLRESKALYDNLYPSRIIVGADLRDTEQVVQAERFATLLQEGSLKPDVETLIMGVTEAEAVKLFANTYLALRVSYFNELDTYAEIKGLDTKSIIDGVGLDPRIGSHYNNPSFGYGGYCLPKDSKQLLANYHDVPQNMMTAIVESNRTRKYFIADRILKNALELSDGNQTIIVGVYRLTMKSGSDNFRQSSIQGVIKCLKAKGVEVIIYEPTLEDHSFFFGNQVVNDLEVFKSSSQVIVANRMEKSLYDVLEKVYTRDIFQRD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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