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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_1860 [new locus tag: SP70585_RS09240 ]
  • pan locus tag?: PNEUPAN003316000
  • symbol: SP70585_1860
  • pan gene symbol?: pkn1
  • synonym:
  • product: sulfatase-modifying factor 1 (C-alpha-formyglycine-generating enzyme 1)

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_1860 [new locus tag: SP70585_RS09240 ]
  • symbol: SP70585_1860
  • product: sulfatase-modifying factor 1 (C-alpha-formyglycine-generating enzyme 1)
  • replicon: chromosome
  • strand: -
  • coordinates: 1726813..1727661
  • length: 849
  • essential: unknown

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGAAAATGAAAAAAATCAAGGGTGGGACATTTATGATGGGAACAAATTCTGAAGAGGGC
    TTTTTAGATGATTTTGAAGGTCCTCAAGTCGCTGTTAGTGTAAAGGATTTTTCCATTGCG
    GATACTCCAGTTACGAATCAAGAATTTGCTCAATTTGTGAAAGAAACAGGCTATAAAACA
    CTAGCTGAGCGACAAGAGTGGTCTTTTGTTTTTATATTGTTCGTTCCAGAGGCAGAAAGG
    GAGGGATATCCTCATCCTGCTGGGGCTCCGTGGTGGTTACAAGTTCCGAACGCTTGCTGG
    AAACATCCCTACGGTGAGAACAGTAATCTAGTGGGTTTAGAAGACCATCCAGTAGTTCAT
    GTTGCTTTAGAAGATGCATTGGCTTTCTGTAATTGGAGCGGAATGTCTTTACCGACTGAA
    GCACAGTGGGAATATGCTGCTAGAGGAGGAAGACAATCTGAATATCCTTGGGGAGATACT
    CTTTTAGAAGGTGGATATTATCATGCCAATACTTGGCAAGGAAGATTTCCTTATGAAAAT
    ACTGCCTTAGATGGATTTATAGGAACGGCTCCTGTCTATGAATTTTTACCTAATGATTTT
    GGTCTATATCAAATGATTGGGAATGTTTGGGAATGGTGTCGCAATCCGAGATATACCTTA
    TTAGCTAGTTTTAATGAAGATGACTATGAGTTGCCAAAATATGGGATACAAGATGAGGAG
    TATGCTATCAGAGGAGGTTCCTTTTTATGTCATTGTTCTTATTGTAATCGATACCGAGTA
    GCTGCTAGAAATGGATGTATTTCTACTTCCACTAGTAGCCATCTAGGTTTTAGATGTTTG
    AAAGAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    849

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SP70585_1860 [new locus tag: SP70585_RS09240 ]
  • symbol: SP70585_1860
  • description: sulfatase-modifying factor 1 (C-alpha-formyglycine-generating enzyme 1)
  • length: 282
  • theoretical pI: 4.60031
  • theoretical MW: 32115.7
  • GRAVY: -0.442199

Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs ergothioneine biosynthesis protein EgtB (TIGR03440; HMM-score: 106.1)
    gliding motility-associated lipoprotein GldK (TIGR03529; HMM-score: 95.1)
    and 5 more
    gliding motility-associated lipoprotein GldK (TIGR03525; HMM-score: 81.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs 5-histidylcysteine sulfoxide synthase (TIGR04344; HMM-score: 61.1)
    gliding motility-associated lipoprotein GldJ (TIGR03530; HMM-score: 42)
    gliding motility-associated lipoprotein GldJ (TIGR03524; HMM-score: 33.8)
    fibrobacter succinogenes paralogous family TIGR02171 (TIGR02171; HMM-score: 24.1)
  • TheSEED  :
    • Sulfatase modifying factor 1 precursor (C-alpha-formyglycine- generating enzyme 1)
    Sulfatases and sulfatase modifying factor 1  Sulfatase modifying factor 1 precursor (C-alpha-formyglycine- generating enzyme 1)
  • PFAM:
    C_Lectin (CL0056) FGE-sulfatase; Sulfatase-modifying factor enzyme 1 (PF03781; HMM-score: 235.2)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.7687
    • Cytoplasmic Membrane Score: 0.0762
    • Cell wall & surface Score: 0.001
    • Extracellular Score: 0.154
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.013863
    • TAT(Tat/SPI): 0.00037
    • LIPO(Sec/SPII): 0.001446
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MKMKKIKGGTFMMGTNSEEGFLDDFEGPQVAVSVKDFSIADTPVTNQEFAQFVKETGYKTLAERQEWSFVFILFVPEAEREGYPHPAGAPWWLQVPNACWKHPYGENSNLVGLEDHPVVHVALEDALAFCNWSGMSLPTEAQWEYAARGGRQSEYPWGDTLLEGGYYHANTWQGRFPYENTALDGFIGTAPVYEFLPNDFGLYQMIGNVWEWCRNPRYTLLASFNEDDYELPKYGIQDEEYAIRGGSFLCHCSYCNRYRVAARNGCISTSTSSHLGFRCLKE

Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Expression & Regulation[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription[edit | edit source]

  • transcription start site:

Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]