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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_2049 [new locus tag: SP70585_RS10180 ]
  • pan locus tag?: PNEUPAN003575000
  • symbol: SP70585_2049
  • pan gene symbol?: lysA
  • synonym:
  • product: diaminopimelate decarboxylase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_2049 [new locus tag: SP70585_RS10180 ]
  • symbol: SP70585_2049
  • product: diaminopimelate decarboxylase
  • replicon: chromosome
  • strand: -
  • coordinates: 1886585..1887835
  • length: 1251
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGAAAACACCATTTATTAATAGAGAAGAGTTAGAAGCGATTGTTGCCGAGTTCCCGACT
    CCCTTTCACTTGTATGATGAGAAGGGGATTCGTGAGAAGGCAAGAGCCGTCAACCAAGCC
    TTTTCGTGGAACAAGGGCTTTAAGGAATATTTTGCAGTTAAGGCTACTCCAACTCCAGCT
    ATTTTGAAAATTCTCCAAGAAGAAGGTTGTGGTGTGGACTGCTCTAGTTATGTAGAGCTT
    TTGATGAGCCATAAACTGGACTTTCTGGGTTCTGAGATTATGTTCTCTTCCAACAACACG
    TCAGACAAGGAATACGCCTATGCACGTGAATTGGGTGCGACCATTAACTTGGATGCCTTT
    GAAGATATTGAACATCTGGAGAGAGTAGCAGGCATTCCAGAAATCATCTCTTGTCGTTAT
    AATCCTGGAGGCGTTTTTGAACTGGGGACAGACATTATGGACAATCCTGGGGAGGCTAAG
    TTTGGCATGACCAAGGACCAGCTCTTTGAAGCCTTTGCTATCTTGAAGGAAAAAGGAGCC
    AAGACTTTTGGGATTCACTCCTTCCTAGCGTCCAATACCGTGACCCATCTCTATTATCCA
    GAGTTGGCTCGTCAGCTCTTTGAACTGGCTGTTGAAATCAAGGAAAAGTTGGGCATTTGG
    CTAGACTTTATCAATCTTTCTGGCGGTATTGGTGTTAATTATCGTCCAGACCAGGAGCCG
    AACGATATCGCCTTGATTGGTGAGGGAGTTCGTAAGGTGTATGAAGAAGTTCTTACGTCA
    GCAGGTCTTGGTCAGGTCAAGATTTTCACCGAATTGGGTCGTTTTATGCTGGCACCTCAC
    GGTGCTCTAGTCACAAGAGTGACTCATAAGAAGGAAACCTACCGTACCTATCTAGGTGTG
    GATGCCTCAGCAGTCAACCTCATGCGTCCAGCTATGTACGGAGCTTACCATCATATTAGC
    AACGTGACCCATCCAGATGGACCAGCTGAAGCGGTAGATGTGGTTGGTTCACTCTGTGAA
    AACAATGATAAATTTGCAGTCAATCGCGAACTGCCTCATACAGAAATCGGTGATTTGCTG
    GTCATTCATGATACAGGTGCCCACGGATTTTCAATGGGCTACCAGTATAATGCCAAATTA
    CGTTCTGCGGAAATCCTCTATACCGAAGAAGGTAAAGCCCGTCAAATCCGCCGTGCAGAG
    CGCCCTGAGGACTATTTTGCAACCTTATATGGCTTCGATTTTGAAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1251

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP70585_2049 [new locus tag: SP70585_RS10180 ]
  • symbol: SP70585_2049
  • description: diaminopimelate decarboxylase
  • length: 416
  • theoretical pI: 4.91844
  • theoretical MW: 46638.5
  • GRAVY: -0.246635

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aspartate family diaminopimelate decarboxylase (TIGR01048; EC 4.1.1.20; HMM-score: 282.1)
    and 2 more
    pyridoxal-dependent decarboxylase, exosortase A system-associated (TIGR03099; HMM-score: 143.7)
    Metabolism Central intermediary metabolism Polyamine biosynthesis arginine decarboxylase (TIGR01273; EC 4.1.1.19; HMM-score: 33.5)
  • TheSEED  :
    • Diaminopimelate decarboxylase (EC 4.1.1.20)
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Lysine Biosynthesis DAP Pathway  Diaminopimelate decarboxylase (EC 4.1.1.20)
  • PFAM:
    TIM_barrel (CL0036) Orn_Arg_deC_N; Pyridoxal-dependent decarboxylase, pyridoxal binding domain (PF02784; HMM-score: 100.6)
    and 1 more
    no clan defined Orn_DAP_Arg_deC; Pyridoxal-dependent decarboxylase, C-terminal sheet domain (PF00278; HMM-score: 77.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005715
    • TAT(Tat/SPI): 0.000866
    • LIPO(Sec/SPII): 0.00063
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKTPFINREELEAIVAEFPTPFHLYDEKGIREKARAVNQAFSWNKGFKEYFAVKATPTPAILKILQEEGCGVDCSSYVELLMSHKLDFLGSEIMFSSNNTSDKEYAYARELGATINLDAFEDIEHLERVAGIPEIISCRYNPGGVFELGTDIMDNPGEAKFGMTKDQLFEAFAILKEKGAKTFGIHSFLASNTVTHLYYPELARQLFELAVEIKEKLGIWLDFINLSGGIGVNYRPDQEPNDIALIGEGVRKVYEEVLTSAGLGQVKIFTELGRFMLAPHGALVTRVTHKKETYRTYLGVDASAVNLMRPAMYGAYHHISNVTHPDGPAEAVDVVGSLCENNDKFAVNRELPHTEIGDLLVIHDTGAHGFSMGYQYNAKLRSAEILYTEEGKARQIRRAERPEDYFATLYGFDFEE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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