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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_RS00555 [old locus tag: SP70585_0112 ]
  • pan locus tag?: PNEUPAN000690000
  • symbol: SP70585_RS00555
  • pan gene symbol?: purL
  • synonym:
  • product: phosphoribosylformylglycinamidine synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_RS00555 [old locus tag: SP70585_0112 ]
  • symbol: SP70585_RS00555
  • product: phosphoribosylformylglycinamidine synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 87813..91538
  • length: 3726
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    3661
    3721
    ATGGATAAACGTATTTTTGTTGAAAAAAAGGCTGATTTTCAGGTCAAGTCAGAGAGTTTG
    GTTAGAGAGCTCCAGCACAACTTGGGACTGTCAAGCTTGAAAAGTATTCGTATTGTGCAA
    GTATATGATGTATTTGACTTGGCTGAGGACTTGTTTGCACCTGCAGAGAAGCACATTTTC
    TCTGAGCAGGTAACCGACCATGTTTTAGATGAAGTATCTGTGCAGGCGGATCTTGCTAAC
    TATGCTTTCTTTGCCATTGAAAGTCTGCCAGGGCAGTTTGACCAGCGTGCAGCTTCGTCA
    CAGGAAGCCTTGCTTTTGTTGGGAAGTTCGAGTGACGTGACAGTCAACACAGCCCAACTT
    TACTTGGTGAATAAAGATATTGATGCGACTGAGTTGAAAGCTGTCAAAAACTACCTGCTC
    AATCTAGTTGATTCTCGTTTCAAGGATATCACGACAGGGATTGCCAAGCAGGAGTTTTCA
    GAGTCAGACAAGACCATTCCAAAATTGACTTTCTTTGAAAGCTATACAGCAGAAGATTTT
    GCTCGCTACAAGGCCGAACAAGGGATGGCCATGGAAGTGGATGATTTGCTCTTTATCCAA
    GACTACTTTAAGTCAATCGGGCGCGTGCCAACTGAGACTGAACTTAAGGTTTTGGACACT
    TACTGGTCTGACCACTGCCGTCATACGACTTTTGAGACAGAGTTGAAACACATCGACTTT
    TCAGCTTCTAAATTTCAAAAGCAATTGCAGTCAACCTATGACAAGTATATTGCCATGCGC
    GAGGAATTAGGTCGGTCTGAAAAACCACAAACCTTGATGGATATGGCGACTATTTTCGGT
    CGTTATGAGCGTGCTAATGGACGATTGGATGATATGGAAGTCTCTGACGAAATCAATGCC
    TGCTCAGTTGAAATTGAAGTGGACGTTGATGGTGTCAAGGAACCTTGGCTCCTCATGTTT
    AAAAACGAAACCCACAACCATCCAACAGAAATTGAGCCATTTGGTGGAGCGGCTACCTGT
    ATTGGTGGAGCTATTCGTGATCCGTTGTCAGGCCGTTCCTATGTTTACCAAGCCATGCGT
    ATTTCAGGTGCTGGTGATATTACAGCACCGATTTCGGAAACTCGCGCTGGGAAATTGCCA
    CAACAAGTCATTTCTAAAACAGCAGCTCATGGTTATTCTTCATATGGTAACCAGATTGGG
    CTTGCCACAACCTACGTTCGTGAATACTTCCACCCAGGCTTTGTAGCTAAACGTATGGAA
    CTTGGTGCCGTTGTTGGTGCGGCTCCCAAGGGCAATGTTGTCCGTGAAAAACCTGAAGCA
    GGTGATGTGATCATCCTTCTCGGAGGTAAAACAGGTCGTGATGGTGTCGGTGGTGCGACG
    GGCTCTTCTAAGGTTCAAACAGTTGAGTCTGTAGAGACTGCTGGTGCTGAGGTTCAAAAA
    GGAAATGCCATCGAAGAACGCAAGATTCAGCGCCTCTTCCGTAATGGCAATGTCACTCGT
    CTGATCAAGAAGTCCAATGACTTTGGGGCAGGCGGTGTCTGTGTGGCTATCGGTGAATTG
    GCAGACGGTCTTGAAATCGACCTCAACAAGGTGCCTCTTAAATACCAGGGCTTGAATGGT
    ACAGAAATTGCCATCTCTGAATCACAAGAACGGATGGCGGTCGTGGTTCGTCCTGAAGAT
    GTGGATACCTTCGTTGCCGAATGTAACAAAGAAAATATTGATGCTGTTGTGGTGGCGACA
    GTAACTGAAAAACCAAATCTTGTCATGCACTGGAATGGTGAGACAATCGTTGACTTGGAG
    CGTCGTTTCCTTGACACCAATGGTGTGCGCGTGGTTGTCGATGCCAAAGTTGTGGACAAG
    GATGTCAAACTCCCAGAAGAGCGTCAAACATCTGCTGAAACACTGGAATCAGATACCCTT
    ACGGTTCTATCTGACCTCAACCATGCAAGTCAAAAAGGATTACAGACTATCTTTGACTGC
    TCTGTTGGACGCTCAACGGTTAATCACCCACTTGGTGGTCGTTACCAACTCACACCAACT
    GAGGCATCTGTGCAGAAATTGCCAGTTCAACACGGTGTGACTCATACTGCGTCGGTCATT
    GCTCAAGGTTTCAACCCATATGTAGCTGAATGGTCTCCATACCACGGTGCTGCTTATGCG
    GTTATCGAAGCAACTGCTCGTTTGGTGGCTGCTGGTGCCAACTGGTCTAAGGCTCGTTTC
    TCTTACCAAGAATATTTCGAGCGGATGGACAAGCAAGCAGAGCGTTTCGGTCAGCCAGTA
    GCTGCTCTTCTAGGTTCTATTGAAGCACAAATTCAGCTTGGCTTGCCATCTATCGGTGGT
    AAGGACTCCATGTCTGGTACCTTTGAAGAATTGACCGTTCCGCCAACCTTGGTTGCCTTT
    GGGGTGACGACGGCAGATAGCCGTAAGGTGCTCTCTCCAGAATTTAAAGCTGTTGGGGAA
    AATATCTACTACATCCCAGGTCAAGCCCTCTCTGCAGAGATTGATTTTGACTTGATTAAG
    AAAAATTTTGCTCAGTTTGAAGCAAGCCAAGCTGACCATAAAGTGACGTCTGCATCAGCT
    GTCAAATACGGTGGTGTAGTTGAAAGTTTGGCTCTTGCTACCTTTGGAAACTATATTGGT
    GCAGAGGTGACCTTGCCTGAACTTAAAACAGCTTTGACAGCTCAATTAGGCGGCTTTGTC
    TTCACATCTCCTGAAGAAATTGCTGGAGTAGAGAAGATTGGACAAACGAAAGCAGACTTT
    ACACTGACTGTCAACGGTGTGAAGCTAGATGGACACAAGCTTGACAGTGCATTTCAAGGG
    ACATTGGAAGAAGTTTACCCAACAGAATTTACCCAAGCGAAAGAACTAGAAGAAGTACCA
    GCTGTGGCATCAGATGTTGTGATTAAAGCCAAAGAAAAGGTTGAAAAACCTGTGGTTTAC
    ATCCCAGTCTTTCCAGGAACCAACTCAGAATATGATTCAGCTAAGGCCTTCGAAAAAGAA
    GGTGCAGAGGTCAATTTGGTGCCATTCGTGACCTTGAATGAAGAAGCTATTGTCAAGTCA
    GTTGAAACTATGGTTGACAATATCGACAAGACTAATATTCTCTTCTTTGCCGGTGGATTC
    TCGGCTGCGGATGAACCAGATGGTTCAGCTAAGTTTATCGTCAATATCCTGCTTAATGAA
    AAAGTGCGTGTGGCTATTGATAGCTTTATCGCCCGTGGTGGCTTGATTATCGGTATTTGT
    AATGGATTCCAAGCCTTAGTCAAATCGGGTCTCCTACCATACGGAAACTTTGAAGATGCT
    AACAGTACTAGTCCAACCCTCTTCTACAATGATGCCAACCAACACGTGGCCAAGATGGTG
    GAAACTCGCATTGCCAATACCAACTCACCATGGTTGGCTGGTGTGCAAGTGGGCGATATC
    CACGCTATTCCTGTTTCGCACGGTGAAGGGAAGTTTGTCGTGACGGCTGAGGAATTTGCA
    GAGCTCCGTGACAATGGACAAATTTTCAGCCAATACGTTGACTTTAACGGTAAACCAAGT
    ATGGATTCTAAGTACAATCCGAATGGTTCTGTCCATGCCATCGAAGGAATTACCAGCAAG
    AATGGTCAAATCATCGGTAAGATGGGCCACTCAGAACGTTATGAGGATGGTCTTTTCCAA
    AATATCCCAGGCAATAAAGACCAACACCTGTTCGCATCAGCGGTTAAACATTTCACTGGA
    AAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3240
    3300
    3360
    3420
    3480
    3540
    3600
    3660
    3720
    3726

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP70585_RS00555 [old locus tag: SP70585_0112 ]
  • symbol: SP70585_RS00555
  • description: phosphoribosylformylglycinamidine synthase
  • length: 1241
  • theoretical pI: 4.75132
  • theoretical MW: 135590
  • GRAVY: -0.210798

⊟Function[edit | edit source]

  • reaction:
    EC 6.3.5.3?  ExPASy
    Phosphoribosylformylglycinamidine synthase ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylformylglycinamidine synthase (TIGR01857; EC 6.3.5.3; HMM-score: 2205.7)
    and 5 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylformylglycinamidine synthase II (TIGR01736; EC 6.3.5.3; HMM-score: 278.1)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylformylglycinamidine synthase (TIGR01735; EC 6.3.5.3; HMM-score: 232.3)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylformylglycinamidine synthase I (TIGR01737; EC 6.3.5.3; HMM-score: 146.9)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides intracellular protease, PfpI family (TIGR01382; HMM-score: 15.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin cobyric acid synthase CobQ (TIGR00313; EC 6.3.5.10; HMM-score: 13.4)
  • TheSEED: see SP70585_0112
  • PFAM:
    Glutaminase_I (CL0014) GATase_5; CobB/CobQ-like glutamine amidotransferase domain (PF13507; HMM-score: 258.6)
    and 4 more
    no clan defined AIRS_C; AIR synthase related protein, C-terminal domain (PF02769; HMM-score: 85.1)
    FGAR-AT_linker; Formylglycinamide ribonucleotide amidotransferase linker domain (PF18072; HMM-score: 46.4)
    Glutaminase_I (CL0014) GATase_3; CobB/CobQ-like glutamine amidotransferase domain (PF07685; HMM-score: 18.3)
    DJ-1_PfpI; DJ-1/PfpI family (PF01965; HMM-score: 11.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001197
    • TAT(Tat/SPI): 0.000194
    • LIPO(Sec/SPII): 0.00017
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MDKRIFVEKKADFQVKSESLVRELQHNLGLSSLKSIRIVQVYDVFDLAEDLFAPAEKHIFSEQVTDHVLDEVSVQADLANYAFFAIESLPGQFDQRAASSQEALLLLGSSSDVTVNTAQLYLVNKDIDATELKAVKNYLLNLVDSRFKDITTGIAKQEFSESDKTIPKLTFFESYTAEDFARYKAEQGMAMEVDDLLFIQDYFKSIGRVPTETELKVLDTYWSDHCRHTTFETELKHIDFSASKFQKQLQSTYDKYIAMREELGRSEKPQTLMDMATIFGRYERANGRLDDMEVSDEINACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPFGGAATCIGGAIRDPLSGRSYVYQAMRISGAGDITAPISETRAGKLPQQVISKTAAHGYSSYGNQIGLATTYVREYFHPGFVAKRMELGAVVGAAPKGNVVREKPEAGDVIILLGGKTGRDGVGGATGSSKVQTVESVETAGAEVQKGNAIEERKIQRLFRNGNVTRLIKKSNDFGAGGVCVAIGELADGLEIDLNKVPLKYQGLNGTEIAISESQERMAVVVRPEDVDTFVAECNKENIDAVVVATVTEKPNLVMHWNGETIVDLERRFLDTNGVRVVVDAKVVDKDVKLPEERQTSAETLESDTLTVLSDLNHASQKGLQTIFDCSVGRSTVNHPLGGRYQLTPTEASVQKLPVQHGVTHTASVIAQGFNPYVAEWSPYHGAAYAVIEATARLVAAGANWSKARFSYQEYFERMDKQAERFGQPVAALLGSIEAQIQLGLPSIGGKDSMSGTFEELTVPPTLVAFGVTTADSRKVLSPEFKAVGENIYYIPGQALSAEIDFDLIKKNFAQFEASQADHKVTSASAVKYGGVVESLALATFGNYIGAEVTLPELKTALTAQLGGFVFTSPEEIAGVEKIGQTKADFTLTVNGVKLDGHKLDSAFQGTLEEVYPTEFTQAKELEEVPAVASDVVIKAKEKVEKPVVYIPVFPGTNSEYDSAKAFEKEGAEVNLVPFVTLNEEAIVKSVETMVDNIDKTNILFFAGGFSAADEPDGSAKFIVNILLNEKVRVAIDSFIARGGLIIGICNGFQALVKSGLLPYGNFEDANSTSPTLFYNDANQHVAKMVETRIANTNSPWLAGVQVGDIHAIPVSHGEGKFVVTAEEFAELRDNGQIFSQYVDFNGKPSMDSKYNPNGSVHAIEGITSKNGQIIGKMGHSERYEDGLFQNIPGNKDQHLFASAVKHFTGK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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