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EF3030
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serotype 5
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serotype 1

NCBI: 15-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_RS00580 [old locus tag: SP70585_0117 ]
  • pan locus tag?: PNEUPAN000696000
  • symbol: purH
  • pan gene symbol?: purH
  • synonym:
  • product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_RS00580 [old locus tag: SP70585_0117 ]
  • symbol: purH
  • product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
  • replicon: chromosome
  • strand: +
  • coordinates: 95292..96839
  • length: 1548
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGACTAAACGCGTCTTAATCAGCGTCTCAGACAAAGCGGGCATTGTTGAATTTGCCCAA
    GAACTCAAAAAACTTGGTTGGGAGATTATCTCAACAGGTGGAACTAAGGTTGCCCTTGAT
    AATGCTGGGGTGGATACCATTGCTATCGATGATGTGACTGGTTTCCCAGAAATGATGGAC
    GGTCGTGTGAAGACCCTCCACCCAAATATCCACGGAGGGCTTCTCGCTCGTCGTGACTTG
    GATAGCCACTTGGAAGCGGTTAAGGACAACAAGATTGAGCTCATTGACCTTGTGGTGGTC
    AACCTTTACCCATTTAAGGAAACTATCCTTAAACCAGATGTGACTTATGCTGATGCAGTT
    GAAAATATCGATATTGGTGGGCCGTCTATGCTTCGTTCAGCAGCGAAAAATCATGCCAGT
    GTTACAGTTGTGGTAGATCCTGCTGACTACGCTGTGGTTTTGGACGAATTGGCAGCAAAC
    GGCGAAACCTCTTATGAAACTCGCCAACGTTTAGCAGCCAAAGTATTTCGTCACACAGCG
    GCTTATGACGCCTTGATTGCAGAATACTTCACAGCTCAAGTGGGTGAAAGCAAGCCTGAA
    AAACTCACTTTGACTTATGACCTCAAGCAACCAATGCGTTACGGTGAGAATCCTCAACAA
    GACGCGGACTTTTACCAGAAAGCTTTGCCTACAGATTACTCTATTGCTTCAGCCAAACAG
    CTCAACGGGAAAGAATTGTCATTTAATAATATCCGTGATGCAGATGCTGCTATCCGTATC
    ATCCGTGACTTCAAAGATAGTCCAACCGTTGTGGCTCTCAAACACATGAATCCATGTGGA
    ATTGGTCAAGCTGATGACATCGAGACTGCTTGGGACTACGCTTATGAGTCTGACCCAGTA
    TCTATCTTTGGTGGGATTGTCGTCCTCAACCGTGAGGTGGATGCTGCGACAGCTGAGAAG
    ATGCACGGCGTTTTCCTCGAAATCATCATTGCACCAAGCTATACGGATGAAGCGCTAGCT
    ATTTTGATCAATAAAAAGAAAAACTTGCGTATCCTTGCCTTGCCATTTAATGCTCAAGAG
    GCTAGCGAAGTGGAAGCAGAATACACAGGTGTAGTCGGTGGACTTCTCGTGCAAAATCAA
    GACGTGGTCAAGGAAAGCCCAGCTGACTGGCAAGTGGTGACCAAACGTCAGCCAACTGAG
    ACAGAAGCGACTGCTCTTGAGTTCGCTTGGAAGGCTATCAAGTACGTCAAATCAAATGGT
    ATTATCGTGACCAACGACCACATGACACTTGGTGTTGGTCCAGGTCAAACCAACCGTGTG
    GCTTCTGTTCGCCTTGCCATTGACCAAGCCAAAGATCGTCTGAACGGGGCGGTCCTTGCT
    TCAGATGCCTTCTTCCCATTTGCGGATAACGTGGAAGAAATCGCCAAAGCAGGAATTAAG
    GCCATCATCCAGCCCGGTGGCTCTGTCCGTGACCAAGAATCCATCGAAGCAGCGGATAAA
    TACGGCTTGACTATGGTCTTTACAGGTGTGAGACATTTTAGACATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1548

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP70585_RS00580 [old locus tag: SP70585_0117 ]
  • symbol: PurH
  • description: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
  • length: 515
  • theoretical pI: 4.79957
  • theoretical MW: 56320.5
  • GRAVY: -0.14466

⊟Function[edit | edit source]

  • reaction:
    EC 2.1.2.3?  ExPASy
    Phosphoribosylaminoimidazolecarboxamide formyltransferase 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
    EC 3.5.4.10?  ExPASy
    IMP cyclohydrolase IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (TIGR00355; EC 2.1.2.3,3.5.4.10; HMM-score: 703.4)
  • TheSEED: see SP70585_0117
  • PFAM:
    CDA (CL0109) AICARFT_IMPCHas; AICARFT/IMPCHase bienzyme (PF01808; HMM-score: 394.2)
    and 2 more
    no clan defined MGS; MGS-like domain (PF02142; HMM-score: 90.7)
    NADP_Rossmann (CL0063) CoA_binding_2; CoA binding domain (PF13380; HMM-score: 18)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011433
    • TAT(Tat/SPI): 0.001274
    • LIPO(Sec/SPII): 0.001125
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTKRVLISVSDKAGIVEFAQELKKLGWEIISTGGTKVALDNAGVDTIAIDDVTGFPEMMDGRVKTLHPNIHGGLLARRDLDSHLEAVKDNKIELIDLVVVNLYPFKETILKPDVTYADAVENIDIGGPSMLRSAAKNHASVTVVVDPADYAVVLDELAANGETSYETRQRLAAKVFRHTAAYDALIAEYFTAQVGESKPEKLTLTYDLKQPMRYGENPQQDADFYQKALPTDYSIASAKQLNGKELSFNNIRDADAAIRIIRDFKDSPTVVALKHMNPCGIGQADDIETAWDYAYESDPVSIFGGIVVLNREVDAATAEKMHGVFLEIIIAPSYTDEALAILINKKKNLRILALPFNAQEASEVEAEYTGVVGGLLVQNQDVVKESPADWQVVTKRQPTETEATALEFAWKAIKYVKSNGIIVTNDHMTLGVGPGQTNRVASVRLAIDQAKDRLNGAVLASDAFFPFADNVEEIAKAGIKAIIQPGGSVRDQESIEAADKYGLTMVFTGVRHFRH

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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