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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
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ASP0581
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ATCC 49619
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Hu15
serotype 19A
Hu17
serotype 19A
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serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
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R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_RS06095 [old locus tag: SP70585_1222 ]
  • pan locus tag?: PNEUPAN002396000
  • symbol: SP70585_RS06095
  • pan gene symbol?: pynA
  • synonym:
  • product: YjjG family noncanonical pyrimidine nucleotidase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_RS06095 [old locus tag: SP70585_1222 ]
  • symbol: SP70585_RS06095
  • product: YjjG family noncanonical pyrimidine nucleotidase
  • replicon: chromosome
  • strand: -
  • coordinates: 1133828..1134541
  • length: 714
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    TTGTCCTACAAATTTCTACTCTTCGACCTCGACCACACTCTTCTTGATTTTGATGCTGCT
    GAGGATGTGGCTTTGACCCAACTTCTAAAAGAAGAAGGAGTTGCGGATATTCAGGCTTAT
    AAAGATTATTACGTTCCTATGAACAAGGCTCTCTGGAAAGACTTGGAGCTAAAGAAAATC
    AGTAAACAAGAACTGGTTAACACGCGCTTTTCTCGTTTATTTGCTCATTTTGGACAGGAA
    AAAGACGGTAGTTTTCTTGCCCAGCGTTACCAATTTTACCTCGCCCAGCAGGGACAAACA
    CTATCGGGCGCTCATGATCTCTTGGACAGCCTCATTGAGCGTGATTATGACTTGTATGCT
    GCGACAAATGGCATTACTGCCATTCAGACAGAACGTTTGGCTCAATCTGGTCTAGCACCT
    TATTTCAATCAAGTCTTTATCTCAGAACAGTTGCAAACTCAAAAGCCGGATGCTCTCTTT
    TATGAAAAGATTGGCCAGCAAATTGCTGGATTTAGTAAAGAAAAGACGCTGATGATTGGA
    GATTCTCTAACCGCCGACATTCAAGGTGGCAATAATGCGGGGATTGACACTATCTGGTAT
    AATCCTCATCACCTCGAAAATCACACACAAGCCCAGCCGACTTACGAAGTCTATTCTTAC
    CAAGACTTGCTGGATTGTTTAGATAAAAATATTCTTGAAAAGATCACATTTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    714

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP70585_RS06095 [old locus tag: SP70585_1222 ]
  • symbol: SP70585_RS06095
  • description: YjjG family noncanonical pyrimidine nucleotidase
  • length: 237
  • theoretical pI: 4.50376
  • theoretical MW: 27147.3
  • GRAVY: -0.377215

⊟Function[edit | edit source]

  • reaction:
    EC 3.1.3.5?  ExPASy
    5'-nucleotidase A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate
  • TIGRFAM:
    noncanonical pyrimidine nucleotidase, YjjG family (TIGR02254; EC 3.1.3.5; HMM-score: 206.6)
    and 19 more
    HAD hydrolase, TIGR02253 family (TIGR02253; HMM-score: 96.9)
    HAD hydrolase, REG-2-like, family IA (TIGR02252; HMM-score: 45.8)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 1 (TIGR01549; HMM-score: 44.9)
    haloacid dehalogenase, type II (TIGR01428; EC 3.8.1.2; HMM-score: 41)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIA (TIGR01460; HMM-score: 37)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIIA (TIGR01662; HMM-score: 35.7)
    Metabolism Energy metabolism Sugars phosphoglycolate phosphatase, bacterial (TIGR01449; EC 3.1.3.18; HMM-score: 35)
    HAD hydrolase, TIGR01459 family (TIGR01459; HMM-score: 33)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 3 (TIGR01509; HMM-score: 32.6)
    Unknown function Enzymes of unknown specificity HAD hydrolase, TIGR01457 family (TIGR01457; HMM-score: 30)
    AHBA synthesis associated protein (TIGR01454; HMM-score: 28.8)
    HAD phosphatase, family IIIA (TIGR01668; EC 3.1.3.-; HMM-score: 27.3)
    pyrimidine 5'-nucleotidase (TIGR01993; EC 3.1.3.5; HMM-score: 25.4)
    beta-phosphoglucomutase family hydrolase (TIGR02009; HMM-score: 18.3)
    phosphoglycolate/pyridoxal phosphate phosphatase family (TIGR01452; EC 3.1.3.18; HMM-score: 18)
    histidinol-phosphate phosphatase domain (TIGR01656; HMM-score: 16.9)
    Unknown function Enzymes of unknown specificity HAD hydrolase, TIGR01458 family (TIGR01458; HMM-score: 15.7)
    HAD hydrolase, family IIID (TIGR02245; HMM-score: 14.2)
    epoxide hydrolase N-terminal domain-like phosphatase (TIGR02247; HMM-score: 14.2)
  • TheSEED: see SP70585_1222
  • PFAM:
    HAD (CL0137) HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 87.2)
    and 3 more
    Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 41.1)
    Hydrolase_like; HAD-hyrolase-like (PF13242; HMM-score: 39.1)
    HAD; haloacid dehalogenase-like hydrolase (PF12710; HMM-score: 19.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9991
    • Cytoplasmic Membrane Score: 0.0003
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0005
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002973
    • TAT(Tat/SPI): 0.000121
    • LIPO(Sec/SPII): 0.000341
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSYKFLLFDLDHTLLDFDAAEDVALTQLLKEEGVADIQAYKDYYVPMNKALWKDLELKKISKQELVNTRFSRLFAHFGQEKDGSFLAQRYQFYLAQQGQTLSGAHDLLDSLIERDYDLYAATNGITAIQTERLAQSGLAPYFNQVFISEQLQTQKPDALFYEKIGQQIAGFSKEKTLMIGDSLTADIQGGNNAGIDTIWYNPHHLENHTQAQPTYEVYSYQDLLDCLDKNILEKITF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Aleš Ulrych, Denisa Petráčková, Jana Goldová, Karolína Buriánková, Linda Doubravová, Pavel Branny
PynA is a pyrimidine 5'-nucleotidase that functions as an antimutator protein in Streptococcus pneumoniae.
FEBS J: 2020, 287(2);267-283
[PubMed:31437335] [WorldCat.org] [DOI] (I p)

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