PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 15-DEC-2024

⊟Summary

• organism: Streptococcus pneumoniae 70585
• locus tag: SP70585_RS10935 [old locus tag: SP70585_2203 ]
• pan locus tag^?: PNEUPAN003724000
• symbol: dapD
• pan gene symbol^?: dapD
• synonym:
• product: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SP70585_RS10935 [old locus tag: SP70585_2203 ]
• symbol: dapD
• product: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase
• replicon: chromosome
• strand: -
• coordinates: 2010062..2010760
• length: 699
• essential: unknown

⊟Accession numbers

• Location: NC_012468 (2010062..2010760) NCBI
• BioCyc: SP70585_RS10935 BioCyc
• MicrobesOnline: see SP70585_2203
• PneumoBrowse for strain D39V: SPV_1923 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  
  ATGACTGCTACAAAAATGAACGCTCAAGAAATTATCCAATTTATCGCCAATGCTGAAAAG
  AAAACCAGTGTCAAAGTAACCTTTGAGGGGCAACTCGCAACTGCTGTGCCTAGCTCTGTT
  GTCAAACTAGGAAATGTCCTATTCGGAGACTGGAAGGACGTGGCTCCGCTTCTTGAAGGT
  TTGGTAGAAAATCAAGATTATGTTGTCGAGCAAGATGCTCGTAATTCTGCAGTTCCTTTG
  CTAGATAAGCGTGCTATCAACGCTCGTATCGAGCCAGGTGCTATTATCCGTGACCAGGTG
  GAAATTGGTGACAATGCTGTTATCATGATGGGAGCTGTTATCAATATCGGTGCTGAAATC
  GGTGCTGGAACCATGATTGACATGGGTGCCATCCTTGGTGGCCGTGCCATCGTTGGAAAA
  AATAGCCACGTTGGTGCAGGTGCAGTTTTGGCAGGTGTGATTGAGCCAGCTAGTGCTGAA
  CCAGTCCGTGTCGGAGACAATGTTCTTATCGGTGCTAATGCAGTGGTTATCGAAGGAGTC
  CAAATCGGTAGTGGTTCAGTTGTCGCTGCAGGAGCTATCGTTACCCAAGATGTCCCAGAA
  AACGTGGTAGTAGCAGGTGTTCCAGCTCGTATCATCAAAGAAATTGATGCCCAAACTCAA
  CAAAAAACAGCGCTAGAGGATGCGCTTCGTACCTTGTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  699
  

⊟Protein

⊟General

• locus tag: SP70585_RS10935 [old locus tag: SP70585_2203 ]
• symbol: DapD
• description: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase
• length: 232
• theoretical pI: 4.4015
• theoretical MW: 23919.4
• GRAVY: 0.340948

⊟Function

• reaction:
  EC 2.3.1.89?  ExPASy
  Tetrahydrodipicolinate N-acetyltransferase Acetyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H₂O = CoA + L-2-acetamido-6-oxoheptanedioate
• TIGRFAM:
  2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase (TIGR03532; EC 2.3.1.89; HMM-score: 353.5)
  and 18 more
  sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family (TIGR03570; HMM-score: 100.7)
  Metabolism Amino acid biosynthesis Aspartate family 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (TIGR00965; EC 2.3.1.117; HMM-score: 82)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD (TIGR01853; EC 2.3.1.191; HMM-score: 58)
  phosphonate metabolim protein, transferase hexapeptide repeat family (TIGR03308; HMM-score: 56.1)
  Metabolism Energy metabolism Other phenylacetic acid degradation protein PaaY (TIGR02287; HMM-score: 51.4)
  Metabolism Amino acid biosynthesis Serine family serine O-acetyltransferase (TIGR01172; EC 2.3.1.30; HMM-score: 48.6)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 43)
  Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 43)
  Metabolism Central intermediary metabolism Amino sugars UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 43)
  colanic acid biosynthesis acetyltransferase WcaF (TIGR04008; EC 2.3.1.-; HMM-score: 39.1)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (TIGR01852; EC 2.3.1.129; HMM-score: 36.3)
  2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (TIGR03536; EC 2.3.1.117; HMM-score: 27.6)
  UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR03992; EC 2.3.1.157,2.7.7.23; HMM-score: 26.8)
  non-ribosomal peptide synthetase terminal domain of unknown function (TIGR02353; HMM-score: 22.2)
  colanic acid biosynthesis acetyltransferase WcaB (TIGR04016; EC 2.3.1.-; HMM-score: 21.3)
  Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR03991; EC 2.3.1.157,2.7.7.23; HMM-score: 19.7)
  Metabolism Central intermediary metabolism Amino sugars UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR03991; EC 2.3.1.157,2.7.7.23; HMM-score: 19.7)
  2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (TIGR03535; EC 2.3.1.117; HMM-score: 18.3)
• TheSEED: see SP70585_2203
• PFAM:
  HEXAPEP (CL0536) Hexapep; Bacterial transferase hexapeptide (six repeats) (PF00132; HMM-score: 80.9)
  no clan defined DapH_N; Tetrahydrodipicolinate succinyltransferase N-terminal (PF08503; HMM-score: 80.9)
  and 2 more
  HEXAPEP (CL0536) Hexapep_2; Hexapeptide repeat of succinyl-transferase (PF14602; HMM-score: 52.6)
  DUF4954; Domain of unknown function (DUF4954) (PF16314; HMM-score: 5.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.95
  • Cytoplasmic Membrane Score: 0.05
  • Cellwall Score: 0
  • Extracellular Score: 0
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.006368
  • TAT(Tat/SPI): 0.000381
  • LIPO(Sec/SPII): 0.000735
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000127466 NCBI
• UniProt: see SP70585_2203

⊟Protein sequence

• MTATKMNAQEIIQFIANAEKKTSVKVTFEGQLATAVPSSVVKLGNVLFGDWKDVAPLLEGLVENQDYVVEQDARNSAVPLLDKRAINARIEPGAIIRDQVEIGDNAVIMMGAVINIGAEIGAGTMIDMGAILGGRAIVGKNSHVGAGAVLAGVIEPASAEPVRVGDNVLIGANAVVIEGVQIGSGSVVAAGAIVTQDVPENVVVAGVPARIIKEIDAQTQQKTALEDALRTL

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: SP70585_RS14065 < SP70585_RS10920 < SP70585_RS10925 < SP70585_RS10930 < dapD

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1923 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications