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serotype 1

NCBI: 17-JAN-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_1866 [new locus tag: SPAP_RS09265 ]
  • pan locus tag?: PNEUPAN003365000
  • symbol: SPAP_1866
  • pan gene symbol?: piuA
  • synonym:
  • product: ABC-type enterochelin transport system, periplasmic component

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_1866 [new locus tag: SPAP_RS09265 ]
  • symbol: SPAP_1866
  • product: ABC-type enterochelin transport system, periplasmic component
  • replicon: chromosome
  • strand: +
  • coordinates: 1758217..1759182
  • length: 966
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGAAAACATCCCTTAAACTTTATTTCACTGCCCTAGTGGCCAGCTTCTTGCTCCTACTT
    GGTGCATGTAGTACAAACTCAAGCACTAGTCAGACAGAGACCAGTAGCTCTGCTCCAACA
    GAGGTAACCATTAAAAGTTCACTGGACGAGGTCAAACTTTCCAAAGTTCCTGAAAAGATT
    GTGACCTTTGACCTCGGCGCTGCGGATACTATTCGCGCTTTAGGATTTGAAAAAAATATC
    ATCGGAATGCCTACAAAAACTATTCCGACTTATCTAAAAGACCTAGTGGGAACTGTCAAA
    AATGTTGGTTCTATGAAAGAACCTGATTTAGAAGCTATCGCCGCCCTTGAGCCTGATTTG
    ATTATCGCTTCACCACGTACACAAAAATTCGTAGACAAATTCAAAGAAATCGCCCCAACC
    GTTCTCTTCCAAGCAAGCAAGGACGACTACTGGACTTCTATCAAGGCTAATATCGAATCC
    TTAGCAAGTGCCTTCGGCGAAACTAGTATACAAAAAGCCAAGGAAGAATTGGCCAAGCTA
    GACAAGAGCATCCAAGAAGTCGCTACTAAAAATGAAAGCTCTGACAAAAAAGCCCTTGCG
    ATCCTCCTTAATGAAGGAAAAATGGCAGCCTTTGGTGCCAAATCTCGTTTCTCTTTCTTA
    TACCAAACCTTGAAATTCAAACCAACTGATACAAAATTTGAAGACTCACGCCACGGACAA
    GAAGTCAGCTTTGAAAGTGTCAAAGAAATCAACCCTGACATCCTCTTTGTCATCAACCGT
    ACCCTTGCCATCGGTGGGGACAACTCTAGCAACGACGGTGTCCTAGAAAATGCCCTTATC
    GCTGAAACACCTGCTGCTAAAAATGGTAAGATTATCCAACTAACACCAGACCTCTGGTAT
    CTAAGCGGAGGCGGACTTGAATCAACAAAACTCATGATTGAAGACATACAAAAAGCTTTG
    AAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    966

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_1866 [new locus tag: SPAP_RS09265 ]
  • symbol: SPAP_1866
  • description: ABC-type enterochelin transport system, periplasmic component
  • length: 321
  • theoretical pI: 5.31536
  • theoretical MW: 34900.8
  • GRAVY: -0.137383

⊟Function[edit | edit source]

  • TIGRFAM:
    heme ABC transporter, heme-binding protein isdE (TIGR03659; HMM-score: 56.2)
    putative ABC transporter PGF-CTERM-modified substrate-binding protein (TIGR04281; HMM-score: 51.9)
    and 1 more
    proposed F420-0 ABC transporter, periplasmic F420-0 binding protein (TIGR03868; HMM-score: 22.7)
  • TheSEED  :
    • Iron compound ABC uptake transporter substrate-binding protein PiuA
  • PFAM:
    Chelatase (CL0043) Peripla_BP_2; Periplasmic binding protein (PF01497; HMM-score: 116.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.17
    • Cytoplasmic Membrane Score: 9.51
    • Cellwall Score: 0.16
    • Extracellular Score: 0.15
    • Internal Helix: 1
  • SignalP: Signal peptide LIPO(Sec/SPII) length 22 aa
    • SP(Sec/SPI): 0.000583
    • TAT(Tat/SPI): 0.00007
    • LIPO(Sec/SPII): 0.999223
    • Cleavage Site: CS pos: 22-23. LGA-CS. Pr: 0.9994
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADM85449 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKTSLKLYFTALVASFLLLLGACSTNSSTSQTETSSSAPTEVTIKSSLDEVKLSKVPEKIVTFDLGAADTIRALGFEKNIIGMPTKTIPTYLKDLVGTVKNVGSMKEPDLEAIAALEPDLIIASPRTQKFVDKFKEIAPTVLFQASKDDYWTSIKANIESLASAFGETSIQKAKEELAKLDKSIQEVATKNESSDKKALAILLNEGKMAAFGAKSRFSFLYQTLKFKPTDTKFEDSRHGQEVSFESVKEINPDILFVINRTLAIGGDNSSNDGVLENALIAETPAAKNGKIIQLTPDLWYLSGGGLESTKLMIEDIQKALK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Maha Jomaa, Jose Yuste, James C Paton, Christopher Jones, Gordon Dougan, Jeremy S Brown
Antibodies to the iron uptake ABC transporter lipoproteins PiaA and PiuA promote opsonophagocytosis of Streptococcus pneumoniae.
Infect Immun: 2005, 73(10);6852-9
[PubMed:16177364] [WorldCat.org] [DOI] (P p)

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