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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 22-FEB-2023

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_RS02070 [old locus tag: SPAP_0421 ]
  • pan locus tag?: PNEUPAN001244000
  • symbol: SPAP_RS02070
  • pan gene symbol?: yrrC
  • synonym: recD2
  • product: SF1B family DNA helicase RecD2

⊟Additional information (user-provided)[edit | edit source]

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_RS02070 [old locus tag: SPAP_0421 ]
  • symbol: SPAP_RS02070
  • product: SF1B family DNA helicase RecD2
  • replicon: chromosome
  • strand: -
  • coordinates: 390500..392134
  • length: 1635
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014494 (390500..392134) NCBI
  • BioCyc: SPAP_RS02070 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0366 PneumoBrowse

⊟Phenotype[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    ATGGAAGTTTATTTTTCAGGAACCATTGAACGGATTATTTTTGAAAATCCCAGCAATTTT
    TATCGCATCCTCCTCCTAGAAATCGACGATACGGACGCAGAGGATTTTGATGATTTTGAA
    ATCATTGTCACAGGAACCATGGCTGATGTAATTGAGGGCGAAGACTATACTTTTTGGGGG
    CAAATTGTCCAGCACTCCAAGTATGGAGAACAACTGCAAATCAGTCGTTATGATCGCGCA
    AAACCAACTAGTAAGGGCTTGGTCAAGTACTTTTCAAGTAGCCATTTCAAGGGGATTGGT
    CTCAAGACAGCTCAGAAAATCGTGGATACCTATGGCGAAAATACCATTGACGAAATTTTG
    CAACACCCAGAAAAGTTAGAAGGCATCGCAGGACTCTCTGCCAAAAATCGCGAGGCTTTC
    GTCTCCACTCTCCGTCTCAACTACGGAACGGAGATGGTTTTGTCCAAACTAGCCAACTAC
    GGCATTCCCAACAAACTAGCCTTTCAGATTCAAGACTTTTACAAGGAAGAAACCCTTGAT
    GTGGTTGAAAATTATCCCTACCAGCTGGTTGAGGATATCAAGGGTTTGGGCTTTACCATT
    GCTGACCAACTAGCTGAGGAACTAGGCATCGAAAGTCAGGCTCCTGAACGCTTCCGCGCC
    GGTCTAGTTCACAGTCTTTTTCAGGCCTGTATGGAAACAGGGGACACCTATGTTGAAGCA
    CGGGATTTGCTGGAACAAACCCTTACTCTCCTTGAGTCTTCCCGTCCCGTGGAACTAGAC
    CCCAGCCAAGTTGCCCAAGAGCTCTCCTACCTGATCGAAGAAGACAAGGTTCAGCAGATT
    GATACCAAGATCTTTGACAACAGCCTCTTTTTCGCTGAGGAAGGCATCCGCAGTCACTTG
    GTTCGTATCCTTGAAAAAGGAAAACAGAAGAGTCATGATTTAGAAACCATTCAAAAACAT
    ATCACTACTATCGAGGAAGAGCTGGGAATTGAGTATGATAACATTCAAAAACAGGCTATC
    TGTGATGCTATCCAGAATAAGGTCTTTATCCTGACAGGTGGGCCTGGTACTGGTAAGACA
    ACTGTTATCAATGGAATCATCGCTGTTTATGCCCTGTTAGAGGGACTTGACTTCAGGAAG
    AAAAGCAATCTGCCTATTCTTCTTGCTGCTCCAACTGGTCGAGCTGCTCGTCGCATGAAT
    GAATTGACAGGTTTGCCTAGCGCGACCATACATCGCCACTTGGGAATGACAGGTGACGAT
    GATACCAGTCATCTGGAAGATTACCTAGATGCTGACTTTATCATCGTGGATGAATTCTCT
    ATGGTAGATACTTGGCTGGCCAATCAACTCTTCTCCAATATCTCTTCTAACAGTAAGATC
    CTCATCGTAGGTGACAGTGATCAGCTACCTTCTGTCAGTCCTGGACAGGTTCTAGCGGAT
    CTGCTTCATATTCCTTTGATTCCTCAGACTCACTTGGAAAAAATTTATCGACAAAGCAAA
    GAATCAACCATCGTCACCCTAGCTAGTCAGATTCGACAGGGCATCTTGCCAGCTGATTTC
    ACCCAAAAAAAGCTGACCGTTCCTACTTTGAAATTGCTAGTGGCCATATTCCTGCCACCA
    TTGAAAAAATCTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1635


⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_RS02070 [old locus tag: SPAP_0421 ]
  • symbol: SPAP_RS02070
  • description: SF1B family DNA helicase RecD2
  • length: 544
  • theoretical pI: 4.53569
  • theoretical MW: 61059
  • GRAVY: -0.183456

⊟Function[edit | edit source]

  • TIGRFAM:
    Unknown function Enzymes of unknown specificity helicase, RecD/TraA family (TIGR01448; HMM-score: 727.7)
    and 14 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair exodeoxyribonuclease V, alpha subunit (TIGR01447; EC 3.1.11.5; HMM-score: 131.5)
    Ti-type conjugative transfer relaxase TraA (TIGR02768; HMM-score: 35.6)
    conjugative transfer relaxase protein TraI (TIGR02760; EC 3.6.4.12; HMM-score: 22.8)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair putative DNA helicase (TIGR00376; EC 3.6.4.12; HMM-score: 22.3)
    Cellular processes Cellular processes Sporulation and germination stage V sporulation protein K (TIGR02881; HMM-score: 20)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA topoisomerase IV, B subunit (TIGR01058; EC 5.99.1.-; HMM-score: 15.9)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 15.2)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair Holliday junction DNA helicase RuvA (TIGR00084; EC 3.6.4.12; HMM-score: 14.8)
    Cellular processes Cellular processes Conjugation P-type conjugative transfer ATPase TrbB (TIGR02782; HMM-score: 14.4)
    P-type DNA transfer ATPase VirB11 (TIGR02788; HMM-score: 14.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion AAA-ATPase EccA (TIGR03922; HMM-score: 13.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle-docking protein FtsY (TIGR00064; HMM-score: 13)
    Metabolism Transport and binding proteins Amino acids, peptides and amines LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 12.3)
    Signal transduction Regulatory functions Protein interactions LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 12.3)
  • TheSEED: see SPAP_0421
  • PFAM:
    P-loop_NTPase (CL0023) AAA_30; AAA domain (PF13604; HMM-score: 136.6)
    AAA_19; AAA domain (PF13245; HMM-score: 114.4)
    and 23 more
    HHH (CL0198) HHH_4; Helix-hairpin-helix containing domain (PF14490; HMM-score: 100.8)
    P-loop_NTPase (CL0023) AAA_11; AAA domain (PF13086; HMM-score: 35.1)
    UvrD-helicase; UvrD/REP helicase N-terminal domain (PF00580; HMM-score: 23.5)
    Viral_helicase1; Viral (Superfamily 1) RNA helicase (PF01443; HMM-score: 21.2)
    HHH (CL0198) HHH_5; Helix-hairpin-helix domain (PF14520; HMM-score: 20.6)
    P-loop_NTPase (CL0023) PhoH; PhoH-like protein (PF02562; HMM-score: 20.2)
    DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 19.1)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 17.8)
    AAA_22; AAA domain (PF13401; HMM-score: 16.3)
    5_3_exonuc_C (CL0464) 5_3_exonuc; 5'-3' exonuclease, C-terminal SAM fold (PF01367; HMM-score: 15.7)
    P-loop_NTPase (CL0023) AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 14.2)
    Helicase_RecD; Helicase (PF05127; HMM-score: 13.9)
    AAA_28; AAA domain (PF13521; HMM-score: 13.8)
    T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 13.6)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 13)
    NTPase_1; NTPase (PF03266; HMM-score: 13)
    AAA_25; AAA domain (PF13481; HMM-score: 12.6)
    MeaB; Methylmalonyl Co-A mutase-associated GTPase MeaB (PF03308; HMM-score: 12.4)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 12.1)
    DAP3; Mitochondrial ribosomal death-associated protein 3 (PF10236; HMM-score: 11.8)
    Zeta_toxin; Zeta toxin (PF06414; HMM-score: 11.3)
    ABC_tran; ABC transporter (PF00005; HMM-score: 11.2)
    DUF2075; Schlafen group 3, DNA/RNA helicase domain (PF09848; HMM-score: 11.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9759
    • Cytoplasmic Membrane Score: 0.016
    • Cell wall & surface Score: 0.0026
    • Extracellular Score: 0.0055
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002607
    • TAT(Tat/SPI): 0.000069
    • LIPO(Sec/SPII): 0.000236
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001855517 NCBI
  • UniProt:

⊟Additional information (user-provided)[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MEVYFSGTIERIIFENPSNFYRILLLEIDDTDAEDFDDFEIIVTGTMADVIEGEDYTFWGQIVQHSKYGEQLQISRYDRAKPTSKGLVKYFSSSHFKGIGLKTAQKIVDTYGENTIDEILQHPEKLEGIAGLSAKNREAFVSTLRLNYGTEMVLSKLANYGIPNKLAFQIQDFYKEETLDVVENYPYQLVEDIKGLGFTIADQLAEELGIESQAPERFRAGLVHSLFQACMETGDTYVEARDLLEQTLTLLESSRPVELDPSQVAQELSYLIEEDKVQQIDTKIFDNSLFFAEEGIRSHLVRILEKGKQKSHDLETIQKHITTIEEELGIEYDNIQKQAICDAIQNKVFILTGGPGTGKTTVINGIIAVYALLEGLDFRKKSNLPILLAAPTGRAARRMNELTGLPSATIHRHLGMTGDDDTSHLEDYLDADFIIVDEFSMVDTWLANQLFSNISSNSKILIVGDSDQLPSVSPGQVLADLLHIPLIPQTHLEKIYRQSKESTIVTLASQIRQGILPADFTQKKLTVPTLKLLVAIFLPPLKKS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Additional information (user-provided)[edit | edit source]

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟'lacZ' fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟Other information (user-provided)[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]


⊟Relevant publications[edit | edit source]

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