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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 08-SEP-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39V
  • locus tag: SPV_RS01980 [old locus tag: SPV_0366 ]
  • pan locus tag?: PNEUPAN001244000
  • symbol: SPV_RS01980
  • pan gene symbol?: yrrC
  • synonym: recD2
  • product: SF1B family DNA helicase RecD2

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPV_RS01980 [old locus tag: SPV_0366 ]
  • symbol: SPV_RS01980
  • product: SF1B family DNA helicase RecD2
  • replicon: chromosome
  • strand: -
  • coordinates: 369261..371627
  • length: 2367
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    ATGGAAGTTTATTTTTCAGGAACCATTGAACGGATTATTTTTGAAAATCCCAGCAATTTT
    TATCGCATCCTCCTCCTAGAAATCGACGATACGGACGCAGAGGATTTTGATGATTTTGAA
    ATCATTGTCACAGGAACCATGGCTGATGTAATTGAGGGCGAAGACTATACTTTTTGGGGG
    CAAATTGTCCAGCACTCCAAGTATGGAGAACAACTGCAAATCAGTCGTTATGATCGCGCA
    AAACCAACTAGTAAGGGCTTGGTCAAGTACTTTTCAAGTAGCCATTTCAAGGGGATTGGT
    CTCAAGACAGCTCAGAAAATCGTGGATACCTATGGCGAAAATACCATTGACGAAATTTTG
    CAACACCCAGAAAAGTTAGAAGGCATCGCAGGACTCTCTGCCAAAAATCGCGAGGCTTTC
    GTCTCCACTCTCCGTCTCAACTACGGTACGGAGATGGTTTTGGCCAAACTAGCCAACTAC
    GGCATTCCCAACAAACTAGCCTTTCAGATTCAAGACTTTTACAAGGAAGAAACCCTTGAT
    GTGGTTGAAAATTATCCCTACCAGCTGGTTGAGGATATCAAGGGTTTGGGCTTTACCATT
    GCTGACCAACTAGCTGAGGAACTAGGCATCGAAAGTCAGGCTCCTGAACGCTTCCGCGCC
    GGTCTAGTTCACAGTCTTTTTCAGGCCTGTATGGAAACAGGGGACACCTATGTTGAAGCA
    CGGGATTTGCTGGAACAAACCCTTACTCTCCTTGAGTCTTCCCGTCCCGTGGAACTAGAC
    CCCAGCCAAGTTGCCCAAGAGCTCTCCTACCTGATCGAAGAAGACAAGGTTCAGCAGATT
    GATACCAAGATCTTTGACAACAGCCTCTTTTTCGCTGAGGAAGGTATCCGCAGTCACTTG
    ATTCGTATCCTTGAAAAAGGAGAACAGAAGAGACAAGATTTAGAAACTATTCAAAAGCAT
    ATCACTACTGTCGAGCAAGAACTGGGGATTGAGTATGATAACATTCAAAAACAAGCTATT
    TGTGACGCTATCCAGAACAAGGTCTTTATCCTGACAGGTGGGCCTGGTACTGGTAAGACA
    ACTGTTATCAATGGAATCATCGCTGTTTATGCCCTTTTAGAAGGACTTGACTTCAGGAAG
    AAAAGCAATCTGCCCATTCTTCTTGCTGCTCCAACTGGTCGAGCTGCTCGTCGCATGAAT
    GAATTGACAGGTTTGCCTAGCGCGACCATACATCGCCACTTGGGAATGACAGGTGACGAT
    GATACCAGTCATCTGGAAGATTACCTAGATGCTGAGTTTATCATCGTGGATGAATTCTCT
    ATGGTAGATACTTGGCTGGCCAATCAACTCTTCTCCAATATCTCTTCTAACAGTAAGATC
    CTCATCGTAGGTGACAGTGATCAGCTACCTTCTGTCAGTCCTGGACAGGTTCTAGCGGAT
    CTGCTTCATATTCCTTTGATTCCTCAGACTCGCTTGGAAAAAATTTATCGACAAAGCAAA
    GAATCAACCATCGTCACCCTAGCTAGTCAGATTCGACAGGGCATCTTGCCAGCTGATTTC
    ACCCAAAAAAAAGCTGACCGTTCCTACTTTGAAATTGCTAGTGGCCATATTCCTGCCACC
    ATTGAAAAAATCTTAGGTGCCGCCCTCAGAAATGGTATTCCCGCCCGTGATATCCAAGTT
    CTGGCTCCTATGTACCGAGGGACGGCAGGGATTGATGCTATCAATCAGCTCATGCAAGAC
    CTGCTCAATCCCCCACAAAAAGATCAACTCAGTTTTGAAGCTCCTCAGTGTCACTATCGT
    AAGAGAGACAAGGTCATTCATTTGGTTAACGATGCTGAAATCAATGTCTTTAATGGGGAT
    TTAGGAGCTATCACAGACCTGATTCCTGGTAAATACACCGAATCGAAACAAGACGAGATT
    GTCATTGATTTTGATAGTAATGAAGTCTCTTACCCCCGTAACGAATGGTACAAGATTCGC
    TTGGCCTATGCCATGAGTATTCATAAGTCTCAGGGAAGTGAGTTCCCAGTTGTCATCCTA
    CCGATTACTAGTGCTAGCCGACGTATGCTGGAGCGAAATCTCATCTACACAGCCATTACA
    CGTGCCAAAAGCAAACTCATCTTACTAGGCGAATTACAAGCCTTCGACTATGCTACCCAA
    CACATCGGAACTGCCCGAAAAACCTATCTGATTGAACGCTTCAGTGATCTACTGGAGAAT
    GTTGAAGAAAAGCAACAAGCTGTCTCTGAAACAGTCACATCAAGTGCCTCTGAACAATCC
    TACATCCTAACCGAAGAAAACTGGGACCGCATCCCAGCCATGATTGGGATTACAGACACA
    GACCTCAAAGAGATTTTTGGAAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2367

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPV_RS01980 [old locus tag: SPV_0366 ]
  • symbol: SPV_RS01980
  • description: SF1B family DNA helicase RecD2
  • length: 788
  • theoretical pI: 4.56917
  • theoretical MW: 88738.9
  • GRAVY: -0.258503

⊟Function[edit | edit source]

  • TIGRFAM:
    Unknown function Enzymes of unknown specificity helicase, RecD/TraA family (TIGR01448; HMM-score: 1068.4)
    and 17 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair exodeoxyribonuclease V, alpha subunit (TIGR01447; EC 3.1.11.5; HMM-score: 219)
    Ti-type conjugative transfer relaxase TraA (TIGR02768; HMM-score: 75.5)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair putative DNA helicase (TIGR00376; EC 3.6.4.12; HMM-score: 24.3)
    conjugative transfer relaxase protein TraI (TIGR02760; EC 3.6.4.12; HMM-score: 24.2)
    Cellular processes Cellular processes Sporulation and germination stage V sporulation protein K (TIGR02881; HMM-score: 19.3)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair helicase-exonuclease AddAB, AddA subunit (TIGR02785; EC 3.1.-.-,3.6.4.12; HMM-score: 17.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase PcrA (TIGR01073; EC 3.6.4.12; HMM-score: 16.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA helicase II (TIGR01075; EC 3.6.4.12; HMM-score: 16.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair Holliday junction DNA helicase RuvA (TIGR00084; EC 3.6.4.12; HMM-score: 14.3)
    Cellular processes Cellular processes Conjugation P-type conjugative transfer ATPase TrbB (TIGR02782; HMM-score: 13.7)
    P-type DNA transfer ATPase VirB11 (TIGR02788; HMM-score: 13.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 13.2)
    Signal transduction Regulatory functions Protein interactions LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 13.2)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA topoisomerase IV, B subunit (TIGR01058; EC 5.99.1.-; HMM-score: 12.8)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 12.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion AAA-ATPase EccA (TIGR03922; HMM-score: 12.7)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle-docking protein FtsY (TIGR00064; HMM-score: 12.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    P-loop_NTPase (CL0023) AAA_30; AAA domain (PF13604; HMM-score: 136.3)
    AAA_19; AAA domain (PF13245; HMM-score: 114.1)
    and 27 more
    HHH (CL0198) HHH_4; Helix-hairpin-helix containing domain (PF14490; HMM-score: 99.4)
    P-loop_NTPase (CL0023) UvrD_C_2; UvrD-like helicase C-terminal domain (PF13538; HMM-score: 68.2)
    SH3 (CL0010) SH3_13; ATP-dependent RecD-like DNA helicase SH3 domain (PF18335; HMM-score: 60.7)
    P-loop_NTPase (CL0023) Viral_helicase1; Viral (Superfamily 1) RNA helicase (PF01443; HMM-score: 45.9)
    AAA_11; AAA domain (PF13086; HMM-score: 33.1)
    UvrD_C; UvrD-like helicase C-terminal domain (PF13361; HMM-score: 30)
    UvrD-helicase; UvrD/REP helicase N-terminal domain (PF00580; HMM-score: 22.4)
    HHH (CL0198) HHH_5; Helix-hairpin-helix domain (PF14520; HMM-score: 19.7)
    P-loop_NTPase (CL0023) PhoH; PhoH-like protein (PF02562; HMM-score: 19.5)
    AAA_22; AAA domain (PF13401; HMM-score: 18.8)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 18.6)
    DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 17.4)
    NTPase_1; NTPase (PF03266; HMM-score: 14.8)
    Herpes_Helicase; Helicase (PF02689; HMM-score: 14.7)
    AAA_12; AAA domain (PF13087; HMM-score: 14.7)
    5_3_exonuc_C (CL0464) 5_3_exonuc; 5'-3' exonuclease, C-terminal SAM fold (PF01367; HMM-score: 14.1)
    P-loop_NTPase (CL0023) AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 13.7)
    T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 13.6)
    AAA_28; AAA domain (PF13521; HMM-score: 13.3)
    MeaB; Methylmalonyl Co-A mutase-associated GTPase MeaB (PF03308; HMM-score: 13)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 12.8)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 12.6)
    Helicase_RecD; Helicase (PF05127; HMM-score: 12.2)
    DUF2075; Schlafen group 3, DNA/RNA helicase domain (PF09848; HMM-score: 11.7)
    AAA_14; AAA domain (PF13173; HMM-score: 11.7)
    AAA_25; AAA domain (PF13481; HMM-score: 11.7)
    ABC_tran; ABC transporter (PF00005; HMM-score: 10.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9827
    • Cytoplasmic Membrane Score: 0.0108
    • Cell wall & surface Score: 0.0015
    • Extracellular Score: 0.0049
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002607
    • TAT(Tat/SPI): 0.000069
    • LIPO(Sec/SPII): 0.000236
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000454488 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEVYFSGTIERIIFENPSNFYRILLLEIDDTDAEDFDDFEIIVTGTMADVIEGEDYTFWGQIVQHSKYGEQLQISRYDRAKPTSKGLVKYFSSSHFKGIGLKTAQKIVDTYGENTIDEILQHPEKLEGIAGLSAKNREAFVSTLRLNYGTEMVLAKLANYGIPNKLAFQIQDFYKEETLDVVENYPYQLVEDIKGLGFTIADQLAEELGIESQAPERFRAGLVHSLFQACMETGDTYVEARDLLEQTLTLLESSRPVELDPSQVAQELSYLIEEDKVQQIDTKIFDNSLFFAEEGIRSHLIRILEKGEQKRQDLETIQKHITTVEQELGIEYDNIQKQAICDAIQNKVFILTGGPGTGKTTVINGIIAVYALLEGLDFRKKSNLPILLAAPTGRAARRMNELTGLPSATIHRHLGMTGDDDTSHLEDYLDAEFIIVDEFSMVDTWLANQLFSNISSNSKILIVGDSDQLPSVSPGQVLADLLHIPLIPQTRLEKIYRQSKESTIVTLASQIRQGILPADFTQKKADRSYFEIASGHIPATIEKILGAALRNGIPARDIQVLAPMYRGTAGIDAINQLMQDLLNPPQKDQLSFEAPQCHYRKRDKVIHLVNDAEINVFNGDLGAITDLIPGKYTESKQDEIVIDFDSNEVSYPRNEWYKIRLAYAMSIHKSQGSEFPVVILPITSASRRMLERNLIYTAITRAKSKLILLGELQAFDYATQHIGTARKTYLIERFSDLLENVEEKQQAVSETVTSSASEQSYILTEENWDRIPAMIGITDTDLKEIFGK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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