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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_0257 [new locus tag: SPCG_RS01350 ]
  • pan locus tag?: PNEUPAN000979000
  • symbol: deoR
  • pan gene symbol?: deoR
  • synonym: pflR
  • product: transcriptional regulator, DeoR family

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPCG_0257 [new locus tag: SPCG_RS01350 ]
  • symbol: deoR
  • product: transcriptional regulator, DeoR family
  • replicon: chromosome
  • strand: +
  • coordinates: 240061..240855
  • length: 795
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    TTGTTGTTTTTTGCTTTTTATTTTGGTAGAATAAAACGGAGGTGTAAAATGAAAAGATTG
    GAACAAATTATTAAATTAGTATCAGAATATGAAAAGATCGACGTTAATACATTATCGGAA
    AAATTAAATGTATCGAAAGTAACGATTAGAAAAGATTTAGATAAATTAGAGTCAAAAGGT
    TTATTACACAGAGAGCATGGATATGCTGTATTAAATAGTGGAGATGACTTAAATGTACGT
    TTGTCAATTAATTATGAAACTAAGAGAAAAATTGTTCAGGAAGCAGTAAAATTGGTGTCA
    GATAATGAAACAATAATGATAGAATCTGGATCGACCTGTGCTTTACTTGCTGAGGAAATT
    TGCAAGCAAAAAAGAAATGTTACGATTGTAACAAATTCGTTTTTTATAGCAAATTTTGTG
    AGAGCTTATGATTCATGTCGTGTTATTGTTCTTGGTGGTGAGTTTCAGAAAGATTCACAG
    GTGACTGTAGGACCTTTATTAAAAGAAATGATACAGACTTTTCATGTGTGTCAAGCTTTT
    GTTGGGACAGATGGTTACGATAAAGAGATGGGCTTTACCGGAAAAGATTTAATGCGCAGT
    GAGGTAGTTCAATATATTTCAGCAGTGTCGGATAAAGTCATTGTCCTAACTGACTCAAGT
    AAATTTGATAAAAGAGGTACAGTAAGAAGATTTGCTTTAAGTCAAGTCTATGAAGTAATA
    ACAGACGAAAAACTTTCTAAACAAAATATAGCTACATTAGAAAATGCTGGGATAATGGTT
    AAGGTAGTTTCGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    795

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_0257 [new locus tag: SPCG_RS01350 ]
  • symbol: DeoR
  • description: transcriptional regulator, DeoR family
  • length: 264
  • theoretical pI: 9.10596
  • theoretical MW: 29979.6
  • GRAVY: -0.123864

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions CRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 23.2)
    and 9 more
    Signal transduction Regulatory functions DNA interactions phosphonate utilization transcriptional regulator PhnR (TIGR03337; HMM-score: 18.4)
    Signal transduction Regulatory functions DNA interactions heat-inducible transcription repressor HrcA (TIGR00331; HMM-score: 17.7)
    Metabolism Energy metabolism Pentose phosphate pathway ribose 5-phosphate isomerase A (TIGR00021; EC 5.3.1.6; HMM-score: 17.6)
    Metabolism Transport and binding proteins Anions phosphonate metabolism transcriptional regulator PhnF (TIGR02325; HMM-score: 16.9)
    Signal transduction Regulatory functions DNA interactions phosphonate metabolism transcriptional regulator PhnF (TIGR02325; HMM-score: 16.9)
    Metabolism Energy metabolism Amino acids and amines histidine utilization repressor (TIGR02018; HMM-score: 16.5)
    Signal transduction Regulatory functions DNA interactions histidine utilization repressor (TIGR02018; HMM-score: 16.5)
    Signal transduction Regulatory functions DNA interactions trehalose operon repressor (TIGR02404; HMM-score: 16.3)
    Signal transduction Regulatory functions DNA interactions biotin operon repressor (TIGR00122; HMM-score: 12.8)
  • TheSEED  :
    • Transcriptional regulator, DeoR family
  • PFAM:
    ISOCOT_Fold (CL0246) DeoRC; DeoR C terminal sensor domain (PF00455; HMM-score: 160.7)
    and 21 more
    HTH (CL0123) HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 62.3)
    HTH_11; HTH domain (PF08279; HMM-score: 39.7)
    GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 32.6)
    Fe_dep_repress; Iron dependent repressor, N-terminal DNA binding domain (PF01325; HMM-score: 25.9)
    TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 22.4)
    MarR; MarR family (PF01047; HMM-score: 21.6)
    HTH_Mga; M protein trans-acting positive regulator (MGA) HTH domain (PF08280; HMM-score: 19.5)
    HTH_41; Helix-turn-helix domain (PF14502; HMM-score: 19.3)
    HTH_36; Helix-turn-helix domain (PF13730; HMM-score: 18.2)
    MarR_2; MarR family (PF12802; HMM-score: 16.9)
    DUF977; Bacterial protein of unknown function (DUF977) (PF06163; HMM-score: 16.6)
    HTH_5; Bacterial regulatory protein, arsR family (PF01022; HMM-score: 16.4)
    Rrf2; Iron-dependent Transcriptional regulator (PF02082; HMM-score: 16.2)
    HTH_34; Winged helix DNA-binding domain (PF13601; HMM-score: 16)
    FeoC; FeoC like transcriptional regulator (PF09012; HMM-score: 15.7)
    HTH_PafC; PafC helix-turn-helix domain (PF19187; HMM-score: 15.7)
    Ribosomal_S25; S25 ribosomal protein (PF03297; HMM-score: 15.6)
    Put_DNA-bind_N; Putative DNA-binding protein N-terminus (PF06971; HMM-score: 15)
    HTH_27; Winged helix DNA-binding domain (PF13463; HMM-score: 13.6)
    HTH_10; HTH DNA binding domain (PF04967; HMM-score: 13)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9795
    • Cytoplasmic Membrane Score: 0.0025
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0179
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003466
    • TAT(Tat/SPI): 0.000136
    • LIPO(Sec/SPII): 0.000642
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACB89509 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLFFAFYFGRIKRRCKMKRLEQIIKLVSEYEKIDVNTLSEKLNVSKVTIRKDLDKLESKGLLHREHGYAVLNSGDDLNVRLSINYETKRKIVQEAVKLVSDNETIMIESGSTCALLAEEICKQKRNVTIVTNSFFIANFVRAYDSCRVIVLGGEFQKDSQVTVGPLLKEMIQTFHVCQAFVGTDGYDKEMGFTGKDLMRSEVVQYISAVSDKVIVLTDSSKFDKRGTVRRFALSQVYEVITDEKLSKQNIATLENAGIMVKVVS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: DeoR/PflR (repression) regulon
    DeoR/PflR(TF)important in Formate metabolism; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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