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serotype 4
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serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
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serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
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serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_0947 [new locus tag: SPCG_RS04925 ]
  • pan locus tag?: PNEUPAN001998000
  • symbol: coaE
  • pan gene symbol?: coaE
  • synonym:
  • product: dephospho-CoA kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPCG_0947 [new locus tag: SPCG_RS04925 ]
  • symbol: coaE
  • product: dephospho-CoA kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 926316..926948
  • length: 633
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    TTGTCCAAACTGTCAAAGGAGGGACTGATGGGAAAAATCATCGGAATCACTGGGGGAATT
    GCCTCTGGTAAGTCAACTGTGACAAATTTTCTAAGACAGCAAGGCTTTCAAGTAGTGGAT
    GCCGACGCAGTCGTCCACCAACTACAGAAACCTGGTGGTCGTCTGTTTGAGGCTCTAGTA
    CAGCACTTTGGGCAAGAAATCATTCTTGAAAACGGAGAACTCAATCGCCCTCTCCTAGCT
    AGTCTCATCTTTTCAAATCCTGATGAACGAGAATGGTCTAAGCAAATTCAAGGGGAGATT
    ATCCGTGAGGAACTGGCTACTTTGAGAGAACAGTTGGCTCAGACAGAAGAGATTTTCTTC
    ATGGATATTCCCCTACTTTTTGAGCAGGACTACAGCGATTGGTTTGCTGAGACTTGGTTG
    GTCTATGTGGACCGAGATGCCCAAGTGGAACGCTTAATGAAAAGGGACCAGTTGTCCAAA
    GATGAAGCTGAGTCTCGTCTGGCAGCCCAGTGGCCTTTAGAAAAAAAGAAAGATTTGGCC
    AGCCAGGTTCTTGATAATAATGGCAATCAGAACCAGCTTCTTAATCAAGTGCATATCCTT
    CTTGAGGGAGGTAGGCAAGATGACAGAGATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    633

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_0947 [new locus tag: SPCG_RS04925 ]
  • symbol: CoaE
  • description: dephospho-CoA kinase
  • length: 210
  • theoretical pI: 4.48615
  • theoretical MW: 23978.9
  • GRAVY: -0.477143

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A dephospho-CoA kinase (TIGR00152; EC 2.7.1.24; HMM-score: 182.4)
    and 4 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine kinase (TIGR00235; EC 2.7.1.48; HMM-score: 14.9)
    Metabolism Central intermediary metabolism Sulfur metabolism adenylyl-sulfate kinase (TIGR00455; EC 2.7.1.25; HMM-score: 14.1)
    Metabolism Central intermediary metabolism Phosphorus compounds phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN (TIGR02322; HMM-score: 13.1)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 11.6)
  • TheSEED  :
    • Dephospho-CoA kinase (EC 2.7.1.24)
    Cofactors, Vitamins, Prosthetic Groups, Pigments Coenzyme A Coenzyme A Biosynthesis  Dephospho-CoA kinase (EC 2.7.1.24)
  • PFAM:
    P-loop_NTPase (CL0023) CoaE; Dephospho-CoA kinase (PF01121; HMM-score: 183.7)
    and 4 more
    AAA_28; AAA domain (PF13521; HMM-score: 28.8)
    dNK; Deoxynucleoside kinase (PF01712; HMM-score: 23.2)
    AAA_18; AAA domain (PF13238; HMM-score: 19.9)
    PRK; Phosphoribulokinase / Uridine kinase family (PF00485; HMM-score: 11.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.78
    • Cytoplasmic Membrane Score: 8.16
    • Cellwall Score: 0.06
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.012422
    • TAT(Tat/SPI): 0.004186
    • LIPO(Sec/SPII): 0.020776
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSKLSKEGLMGKIIGITGGIASGKSTVTNFLRQQGFQVVDADAVVHQLQKPGGRLFEALVQHFGQEIILENGELNRPLLASLIFSNPDEREWSKQIQGEIIREELATLREQLAQTEEIFFMDIPLLFEQDYSDWFAETWLVYVDRDAQVERLMKRDQLSKDEAESRLAAQWPLEKKKDLASQVLDNNGNQNQLLNQVHILLEGGRQDDRD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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