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serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_1619 [new locus tag: SPCG_RS08380 ]
  • pan locus tag?: PNEUPAN003060000
  • symbol: SPCG_1619
  • pan gene symbol?: —
  • synonym:
  • product: metallo-beta-lactamase superfamily protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPCG_1619 [new locus tag: SPCG_RS08380 ]
  • symbol: SPCG_1619
  • product: metallo-beta-lactamase superfamily protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1588767..1589447
  • length: 681
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    TTGAAGAGATTTTCGAAGAGTATTAGTACATTCTTTGAGATTGGAGCTAGTATGAAAATC
    CATAAAACCGTGAATCCTGTTGCCTATGAAAATACCTATTATCTAGAAGGCGAAAAGCAC
    CTCATCGTCGTCGATCCTGGTAGTCATTGGGAAGCCATTCGTCAGACAATCGAGAAGATC
    AACAAACCGATCTGTGCTATTCTCTTGACCCACGCCCATTATGACCATATCATGAGTCTG
    GACTTGGTTCGCGAGACGTTTGGCAATCCTCCTGTCTATATCGCAGAGAGCGAAGCCAGC
    TGGCTCTACACTCCTGTCGATAATCTCTCCGGTCTCCCTCGCCACGATGATATGGCAGAT
    GTGGTCACAAAACCTGCAGAACACACCTTTGTCTTTCACGAAGAATACCAACTAGAGGAA
    TTTCGTTTTAAGGTTCTACCGACCCCAGGGCACTCTATCGGTGGTGTTTCCCTAGTCTTT
    CCTGATGCTCACCTAGTCTTGACGGGAGATGCTCTATTCCGCGAAACTATCGGACGGACC
    GACCTTCCGACTGGTAGCATGGAGCAACTCCTTCATAGTATCCAGACCCAACTCTTCACC
    CTACCAAACTACGATGTCTATCCAGGACATGGTCCAGCTACTACTATCGCTCACGAAAAG
    GCCTTCAATCCCTTTTTCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    681

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_1619 [new locus tag: SPCG_RS08380 ]
  • symbol: SPCG_1619
  • description: metallo-beta-lactamase superfamily protein
  • length: 226
  • theoretical pI: 5.9896
  • theoretical MW: 25563.9
  • GRAVY: -0.175664

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Detoxification hydroxyacylglutathione hydrolase (TIGR03413; EC 3.1.2.6; HMM-score: 67.9)
    and 6 more
    Unknown function Enzymes of unknown specificity quinoprotein relay system zinc metallohydrolase 1 (TIGR04558; HMM-score: 41.6)
    Unknown function Enzymes of unknown specificity quinoprotein relay system zinc metallohydrolase 2 (TIGR04559; EC 3.-.-.-; HMM-score: 34.2)
    Genetic information processing Transcription Degradation of RNA beta-CASP ribonuclease, RNase J family (TIGR00649; EC 3.1.-.-; HMM-score: 17.6)
    Genetic information processing Transcription RNA processing ribonuclease Z (TIGR02651; EC 3.1.26.11; HMM-score: 12.1)
    phosphonate metabolism protein PhnP (TIGR03307; HMM-score: 11.7)
    arCOG00543 universal archaeal KH-domain/beta-lactamase-domain protein (TIGR03675; HMM-score: 11.5)
  • TheSEED  :
    • Hydroxyacylglutathione hydrolase (EC 3.1.2.6)
    Carbohydrates Central carbohydrate metabolism Methylglyoxal Metabolism  Hydroxyacylglutathione hydrolase (EC 3.1.2.6)
    and 3 more
    Potassium metabolism Potassium metabolism - no subcategory Glutathione-regulated potassium-efflux system and associated functions  Hydroxyacylglutathione hydrolase (EC 3.1.2.6)
    Stress Response Oxidative stress Glutathione: Non-redox reactions  Hydroxyacylglutathione hydrolase (EC 3.1.2.6)
    Virulence, Disease and Defense Resistance to antibiotics and toxic compounds Cobalt-zinc-cadmium resistance  Hydroxyacylglutathione hydrolase (EC 3.1.2.6)
  • PFAM:
    Metallo-HOrase (CL0381) Lactamase_B; Metallo-beta-lactamase superfamily (PF00753; HMM-score: 107.9)
    and 3 more
    Lactamase_B_2; Beta-lactamase superfamily domain (PF12706; HMM-score: 30.4)
    Lactamase_B_3; Beta-lactamase superfamily domain (PF13483; HMM-score: 19.8)
    Lactamase_B_6; Metallo-beta-lactamase superfamily domain (PF16661; HMM-score: 13.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9991
    • Cytoplasmic Membrane Score: 0.0005
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0004
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.023828
    • TAT(Tat/SPI): 0.000813
    • LIPO(Sec/SPII): 0.004941
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACB90871 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKRFSKSISTFFEIGASMKIHKTVNPVAYENTYYLEGEKHLIVVDPGSHWEAIRQTIEKINKPICAILLTHAHYDHIMSLDLVRETFGNPPVYIAESEASWLYTPVDNLSGLPRHDDMADVVTKPAEHTFVFHEEYQLEEFRFKVLPTPGHSIGGVSLVFPDAHLVLTGDALFRETIGRTDLPTGSMEQLLHSIQTQLFTLPNYDVYPGHGPATTIAHEKAFNPFF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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