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JJA
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MDRSPN001
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NCTC7466
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NU83127
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OXC141
serotype 3
P1031
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R6
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SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
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SPN994038
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SPN994039
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SPNA45
serotype 3
ST556
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TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_2095 [new locus tag: SPCG_RS11095 ]
  • pan locus tag?: PNEUPAN003679000
  • symbol: ilvD
  • pan gene symbol?: ilvD
  • synonym:
  • product: dihydroxy-acid dehydratase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPCG_2095 [new locus tag: SPCG_RS11095 ]
  • symbol: ilvD
  • product: dihydroxy-acid dehydratase
  • replicon: chromosome
  • strand: -
  • coordinates: 2083544..2085247
  • length: 1704
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGACTGAATTAGATAAACGTCACCGCAGTAGCATCTATGACAGCATGGTTAAATCACCT
    AACCGTGCTATGCTTCGTGCGACTGGTATGACAGATAAGGACTTTGAAACATCGATTGTG
    GGAGTGATTTCGACTTGGGCGGAAAATACACCATGTAACATTCACTTGCATGATTTCGGG
    AAACTGGCTAAAGAAGGTGTCAAATCTGCAGGCGCTTGGCCTGTACAGTTTGGAACCATT
    ACCGTAGCGGACGGGATCGCTATGGGAACGCCTGGTATGCGTTTCTCTCTAACATCTCGT
    GACATCATCGCGGACTCCATCGAGGCGGCTATGAGTGGTCACAACGTGGATGCCTTCGTC
    GCTATCGGTGGCTGTGACAAGAACATGCCTGGATCTATGATTGCTATTGCTAATATGGAT
    ATCCCAGCTATTTTCGCCTATGGTGGAACTATTGCACCGGGAAATCTTGATGGTAAAGAT
    ATCGACTTGGTTTCTGTCTTTGAAGGTATCGGAAAATGGAACCACGGTGACATGACAGCT
    GAGGACGTGAAACGTCTTGAATGTAATGCCTGCCCTGGCCCTGGTGGCTGTGGTGGTATG
    TATACTGCTAATACCATGGCAACTGCTATCGAAGTTCTAGGGATGAGTTTGCCAGGGTCA
    TCCTCTCACCCAGCTGAATCAGCTGATAAGAAAGAAGATATCGAAGCAGCAGGACGTGCT
    GTTGTTAAGATGTTGGAACTTGGTCTCAAACCATCAGATATCTTGACTCGTGAAGCCTTT
    GAAGATGCTATCACTGTAACGATGGCTCTCGGTGGTTCTACAAACGCCACTCTTCACTTG
    CTCGCCATTGCCCATGCCGCAAATGTTGACTTGTCACTTGAGGACTTCAATACGATTCAA
    GAACGTGTGCCTCACTTGGCCGACTTGAAACCATCTGGTCAGTATGTCTTCCAAGACCTC
    TACGAAGTCGGTGGTGTCCCTGCGGTTATGAAGTACTTGTTGGCAAATGGTTTCCTTCAC
    GGAGATCGCATCACATGTACTGGTAAGACTGTAGCTGAAAACTTGGCTGACTTTGCAGAC
    TTGACTCCAGGCCAAAAAGTTATCATGCCACTTGAAAATCCAAAACGTGCGGATGGTCCG
    CTTATCATCTTGAACGGGAACCTTGCTCCTGACGGTGCAGTTGCCAAGGTATCAGGTGTT
    AAAGTGCGTCGTCACGTTGGGCCAGCTAAGGTCTTTGACTCAGAAGAAGATGCGATTCAG
    GCCGTTCTGACAGATGAAATCGTTGATGGCGATGTAGTCGTTGTTCGTTTTGTTGGACCT
    AAAGGTGGTCCTGGTATGCCTGAGATGCTGTCACTTTCTTCAATGATTGTTGGTAAAGGT
    CAGGGAGATAAGGTGGCCCTCTTGACGGACGGACGTTTCTCTGGTGGTACTTATGGTCTG
    GTTGTTGGACATATCGCTCCTGAAGCTCAGGATGGTGGACCAATTGCCTATCTCCGTACC
    GGCGATATCGTTACGGTTGACCAAGATACCAAAGAAATTTCCATGGCCGTATCCGAAGAA
    GAACTTGAAAAACGCAAGGCAGAAACAACCTTGCCACCACTTTACAGCCGTGGTGTCCTC
    GGTAAATATGCCTACATCGTATCATCTGCTTCACGCGGAGCCGTGACAGACTTCTGGAAT
    ATGGACAAGTCAGGTAAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1704

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_2095 [new locus tag: SPCG_RS11095 ]
  • symbol: IlvD
  • description: dihydroxy-acid dehydratase
  • length: 567
  • theoretical pI: 4.83443
  • theoretical MW: 59885
  • GRAVY: -0.0430335

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Amino acid biosynthesis Pyruvate family dihydroxy-acid dehydratase (TIGR00110; EC 4.2.1.9; HMM-score: 710.9)
    and 2 more
    Metabolism Energy metabolism Entner-Doudoroff phosphogluconate dehydratase (TIGR01196; EC 4.2.1.12; HMM-score: 251.5)
    Unknown function Enzymes of unknown specificity putative dehydratase, YjhG/YagF family (TIGR03432; HMM-score: 249.6)
  • TheSEED  :
    • Dihydroxy-acid dehydratase (EC 4.2.1.9)
    Amino Acids and Derivatives Branched-chain amino acids Branched-Chain Amino Acid Biosynthesis  Dihydroxy-acid dehydratase (EC 4.2.1.9)
  • PFAM:
    no clan defined ILVD_EDD; Dehydratase family (PF00920; HMM-score: 684.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.015245
    • TAT(Tat/SPI): 0.00337
    • LIPO(Sec/SPII): 0.001284
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTELDKRHRSSIYDSMVKSPNRAMLRATGMTDKDFETSIVGVISTWAENTPCNIHLHDFGKLAKEGVKSAGAWPVQFGTITVADGIAMGTPGMRFSLTSRDIIADSIEAAMSGHNVDAFVAIGGCDKNMPGSMIAIANMDIPAIFAYGGTIAPGNLDGKDIDLVSVFEGIGKWNHGDMTAEDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLPGSSSHPAESADKKEDIEAAGRAVVKMLELGLKPSDILTREAFEDAITVTMALGGSTNATLHLLAIAHAANVDLSLEDFNTIQERVPHLADLKPSGQYVFQDLYEVGGVPAVMKYLLANGFLHGDRITCTGKTVAENLADFADLTPGQKVIMPLENPKRADGPLIILNGNLAPDGAVAKVSGVKVRRHVGPAKVFDSEEDAIQAVLTDEIVDGDVVVVRFVGPKGGPGMPEMLSLSSMIVGKGQGDKVALLTDGRFSGGTYGLVVGHIAPEAQDGGPIAYLRTGDIVTVDQDTKEISMAVSEEELEKRKAETTLPPLYSRGVLGKYAYIVSSASRGAVTDFWNMDKSGKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CodY (activation (repression)) regulon
    CodY(TF)important in Amino acid metabolism; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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