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serotype 1

NCBI: 16-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_RS03415 [old locus tag: SPCG_0653 ]
  • pan locus tag?: PNEUPAN001616000
  • symbol: pyrF
  • pan gene symbol?: pyrF
  • synonym:
  • product: orotidine-5'-phosphate decarboxylase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPCG_RS03415 [old locus tag: SPCG_0653 ]
  • symbol: pyrF
  • product: orotidine-5'-phosphate decarboxylase
  • replicon: chromosome
  • strand: +
  • coordinates: 657316..658017
  • length: 702
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGCGAGAACATCGTCCAATCATTGCTCTTGATTTTCCTAGTTTTGAGGCGGTCAAGGAA
    TTTTTAGCTCTTTTCCCAGCAGAAGAAAGCCTTTATCTCAAGGTAGGGATGGAGCTTTAT
    TACGCAGCGGGGCCTGAGATTGTGTCCTACTTAAAAGGTTTGGGTCATAGTGTCTTTTTG
    GATCTCAAACTTCATGACATTCCTAATACAGTCAAGTCAGCCATGAAGATCCTATCTCAG
    CTTGGTGTGGATATGACCAATGTTCATGCGGCTGGTGGTGTAGAGATGATGAAGGCTGCG
    CGTGAAGGTCTTGGAAGTCAAGCTAAATTGATCGCTGTAACTCAGCTCACATCAACGTCA
    GAAGCTCAGATGCAGGAGTTTCAAAATATCCAAACCAGTCTGCAAGAGTCTGTGATTCAC
    TATGCCAAGAAGACAGCTGAAGCTGGCTTGGATGGTGTTGTTTGCTCGGCTCAGGAAGTA
    CAAGTCATCAAGCAGGCTACCAATCCAGATTTTATCTGTCTGACACCAGGGATTCGTCCA
    GCTGGTGTTGCAGTTGGAGATCAAAAACGAGTCATGACACCTGCTGATGCCTATCAAATC
    GGCAGTGACTATATCGTAGTGGGACGTCCCATTACCCAAGCTGAGGAGCCTGTTGCAGCT
    TATCATGCCATCAAGGATGAATGGACACAGGACTGGAATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    702

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_RS03415 [old locus tag: SPCG_0653 ]
  • symbol: PyrF
  • description: orotidine-5'-phosphate decarboxylase
  • length: 233
  • theoretical pI: 4.93232
  • theoretical MW: 25437
  • GRAVY: -0.0334764

⊟Function[edit | edit source]

  • reaction:
    EC 4.1.1.23?  ExPASy
    Orotidine-5'-phosphate decarboxylase Orotidine 5'-phosphate = UMP + CO2
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotidine 5'-phosphate decarboxylase (TIGR01740; EC 4.1.1.23; HMM-score: 212)
    and 4 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotidine 5'-phosphate decarboxylase (TIGR02127; EC 4.1.1.23; HMM-score: 31.2)
    3-hexulose-6-phosphate synthase (TIGR03128; EC 4.1.2.43; HMM-score: 22.2)
    predicted phospho-2-dehydro-3-deoxyheptonate aldolase (TIGR01949; EC 4.2.1.-; HMM-score: 13.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin probable molybdenum cofactor biosynthesis protein A (TIGR02668; HMM-score: 11.4)
  • TheSEED: see SPCG_0653
  • PFAM:
    TIM_barrel (CL0036) OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family (PF00215; HMM-score: 172.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9997
    • Cytoplasmic Membrane Score: 0.0001
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0001
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001992
    • TAT(Tat/SPI): 0.000179
    • LIPO(Sec/SPII): 0.000239
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MREHRPIIALDFPSFEAVKEFLALFPAEESLYLKVGMELYYAAGPEIVSYLKGLGHSVFLDLKLHDIPNTVKSAMKILSQLGVDMTNVHAAGGVEMMKAAREGLGSQAKLIAVTQLTSTSEAQMQEFQNIQTSLQESVIHYAKKTAEAGLDGVVCSAQEVQVIKQATNPDFICLTPGIRPAGVAVGDQKRVMTPADAYQIGSDYIVVGRPITQAEEPVAAYHAIKDEWTQDWN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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