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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu15
  • locus tag: SPNHU15_RS03470 [old locus tag: SPNHU15_00742 ]
  • pan locus tag?: PNEUPAN001616000
  • symbol: pyrF
  • pan gene symbol?: pyrF
  • synonym:
  • product: orotidine-5'-phosphate decarboxylase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU15_RS03470 [old locus tag: SPNHU15_00742 ]
  • symbol: pyrF
  • product: orotidine-5'-phosphate decarboxylase
  • replicon: chromosome
  • strand: +
  • coordinates: 708832..709533
  • length: 702
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP020551 (708832..709533) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0608 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGCGAGAACATCGTCCAATCATTGCTCTTGATTTTCCTAGTTTTGAGGTGGTCAAGGAA
    TTTTTAGCTCTTTTCCCAGCAGAAGAAAGCCTTTATCTCAAGGTAGGGATGGAGCTTTAT
    TACGCAGCGGGGCCTGAGATTGTGTCCTACTTAAAAGGTTTGGGTCATAGTGTCTTTTTG
    GATCTCAAACTTCATGACATTCCCAATACAGTCAAGTCAGCAATGAAGATCCTATCTCAG
    CTTGGTGTGGATATGACCAATGTTCATGCGGCTGGTGGTGTAGAGATGATGAAGGCTGCG
    CGTGAAGGTCTTGGAAGTCAAGCTAAATTGATCGCTGTAACTCAGCTCACATCAACGTCA
    GAAGCTCAGATGCAGGAGTTTCAAAATATCCAAACCAGTCTGCAAGAGTCTGTGATTCAC
    TATGCCAAGAAGACAGCTGAAGCTGGCTTGGATGGTGTTGTTTGCTCGGCTCAGGAAGTA
    CAAGTCATCAAGCAGGCTACCAATCCAGATTTTATCTGTCTGACACCAGGGATTCGTCCA
    GCTGGTGTTGCAGTTGGAGATCAAAAACGAGTCATGACACCTGCTGATGCCTATCAAATC
    GGCAGTGACTATATCGTAGTGGGACGTCCCATTACCCAAGCTGAGGATCCTGTTGCAGCT
    TATCATGCCATCAAGGATGAATGGACACAGGACTGGAATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    702

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU15_RS03470 [old locus tag: SPNHU15_00742 ]
  • symbol: PyrF
  • description: orotidine-5'-phosphate decarboxylase
  • length: 233
  • theoretical pI: 4.92593
  • theoretical MW: 25451
  • GRAVY: -0.023176

⊟Function[edit | edit source]

  • reaction:
    EC 4.1.1.23?  ExPASy
    Orotidine-5'-phosphate decarboxylase Orotidine 5'-phosphate = UMP + CO2
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotidine 5'-phosphate decarboxylase (TIGR01740; EC 4.1.1.23; HMM-score: 212.8)
    and 4 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotidine 5'-phosphate decarboxylase (TIGR02127; EC 4.1.1.23; HMM-score: 30.6)
    3-hexulose-6-phosphate synthase (TIGR03128; EC 4.1.2.43; HMM-score: 21.9)
    predicted phospho-2-dehydro-3-deoxyheptonate aldolase (TIGR01949; EC 4.2.1.-; HMM-score: 13.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin probable molybdenum cofactor biosynthesis protein A (TIGR02668; HMM-score: 11.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    TIM_barrel (CL0036) OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family (PF00215; HMM-score: 172.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9997
    • Cytoplasmic Membrane Score: 0.0001
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0002
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001918
    • TAT(Tat/SPI): 0.000169
    • LIPO(Sec/SPII): 0.000238
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001206724 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MREHRPIIALDFPSFEVVKEFLALFPAEESLYLKVGMELYYAAGPEIVSYLKGLGHSVFLDLKLHDIPNTVKSAMKILSQLGVDMTNVHAAGGVEMMKAAREGLGSQAKLIAVTQLTSTSEAQMQEFQNIQTSLQESVIHYAKKTAEAGLDGVVCSAQEVQVIKQATNPDFICLTPGIRPAGVAVGDQKRVMTPADAYQIGSDYIVVGRPITQAEDPVAAYHAIKDEWTQDWN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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