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NCBI: 24-JAN-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_RS05725 [old locus tag: SPCG_1105 ]
  • pan locus tag?: PNEUPAN002458000
  • symbol: lacA
  • pan gene symbol?: lacA
  • synonym:
  • product: galactose-6-phosphate isomerase subunit LacA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPCG_RS05725 [old locus tag: SPCG_1105 ]
  • symbol: lacA
  • product: galactose-6-phosphate isomerase subunit LacA
  • replicon: chromosome
  • strand: +
  • coordinates: 1076095..1076520
  • length: 426
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGTCTATTGTTATCGGTGCAGATGCTGCAGGTTTGAGATTGAAAGAAGTTGTGAAAGAC
    TTCTTAGAAAAAGAAAACTTCCACCTTGTGGATGTTACAGCTGAAGGTCAAGACTTTGTT
    GATGTGACTCTCGCTGTTGCTGCAGAAGTAAACAAAGAAGAACAAAACCTTGGTATCGTG
    ATTGATGCTTATGGAGCTGGTCCATTTATGGTTGCAACTAAGATCAAAGGAATGGTTGCT
    GCAGAAGTATCTGACGAACGTTCAGCTTATATGACTCGTGGCCACAACAACTCACGTATG
    ATCACTATGGGTGCACAACTTGTTGGTGATGAATTGGCTAAAAACATCGCTAAAGGATTT
    GTTAACGGTAAATACGATGGTGGACGTCATCAAATCCGGGTCGACATGTTGAACAAAATG
    GGCTAA
    60
    120
    180
    240
    300
    360
    420
    426

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_RS05725 [old locus tag: SPCG_1105 ]
  • symbol: LacA
  • description: galactose-6-phosphate isomerase subunit LacA
  • length: 141
  • theoretical pI: 5.23225
  • theoretical MW: 15244.4
  • GRAVY: -0.0737589

⊟Function[edit | edit source]

  • reaction:
    EC 5.3.1.26?  ExPASy
    Galactose-6-phosphate isomerase D-galactose 6-phosphate = D-tagatose 6-phosphate
  • TIGRFAM:
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides galactose-6-phosphate isomerase, LacA subunit (TIGR01118; EC 5.3.1.26; HMM-score: 261.6)
    and 6 more
    sugar-phosphate isomerase, RpiB/LacA/LacB family (TIGR00689; EC 5.3.1.-; HMM-score: 114.3)
    Metabolism Energy metabolism Pentose phosphate pathway ribose 5-phosphate isomerase B (TIGR01120; EC 5.3.1.6; HMM-score: 103.7)
    ribose 5-phosphate isomerase (TIGR02133; EC 5.3.1.6; HMM-score: 86.4)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides galactose-6-phosphate isomerase, LacB subunit (TIGR01119; EC 5.3.1.26; HMM-score: 37)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, mannose/fructose/sorbose family, IIA component (TIGR00824; EC 2.7.1.69; HMM-score: 13.3)
    Signal transduction Signal transduction PTS PTS system, mannose/fructose/sorbose family, IIA component (TIGR00824; EC 2.7.1.69; HMM-score: 13.3)
  • TheSEED: see SPCG_1105
  • PFAM:
    no clan defined LacAB_rpiB; Ribose/Galactose Isomerase (PF02502; HMM-score: 121.6)
    and 1 more
    NADP_Rossmann (CL0063) HcgC; FeGP cofactor biosynthesis protein, methyltransferase HcgC (PF06690; HMM-score: 15)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002046
    • TAT(Tat/SPI): 0.000169
    • LIPO(Sec/SPII): 0.000225
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSIVIGADAAGLRLKEVVKDFLEKENFHLVDVTAEGQDFVDVTLAVAAEVNKEEQNLGIVIDAYGAGPFMVATKIKGMVAAEVSDERSAYMTRGHNNSRMITMGAQLVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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