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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-JAN-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A026
  • locus tag: T308_RS04845 [old locus tag: T308_04800 ]
  • pan locus tag?: PNEUPAN002458000
  • symbol: lacA
  • pan gene symbol?: lacA
  • synonym:
  • product: galactose-6-phosphate isomerase subunit LacA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: T308_RS04845 [old locus tag: T308_04800 ]
  • symbol: lacA
  • product: galactose-6-phosphate isomerase subunit LacA
  • replicon: chromosome
  • strand: +
  • coordinates: 932895..933320
  • length: 426
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_022655 (932895..933320) NCBI
  • BioCyc: T308_RS04845 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1053 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGTCTATTGTTATCGGTGCAGATGCTGCAGGTTTGAGATTGAAAGAAGTTGTGAAAGAC
    TTCTTAGAAAAAGAAAACTTCCACCTTGTGGATGTTACAGCTGAAGGTCAAGACTTTGTT
    GATGTGACTCTCGCTGTTGCTGCAGAAGTAAACAAAGAAGAACAAAACCTTGGTATCGTG
    ATTGATGCTTATGGAGCTGGTCCATTTATAGTTGCAACTAAGATCAAAGGAATGGTTGCT
    GCAGAAGTATCTGACGAACGTTCAGCTTATATGACTCGTAGCCACAACAACTCACGTATG
    ATCACTATGGGGGCACAACTTGTTGGTGATGAATTGGCTAAAAACATCGCTAAAGGATTT
    GTTAATGGTAAATACGACGGTGGACGTCATCAAATCCGGGTTGACATGTTGAACAAAATG
    GGCTAA
    60
    120
    180
    240
    300
    360
    420
    426

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: T308_RS04845 [old locus tag: T308_04800 ]
  • symbol: LacA
  • description: galactose-6-phosphate isomerase subunit LacA
  • length: 141
  • theoretical pI: 5.23225
  • theoretical MW: 15256.4
  • GRAVY: -0.058156

⊟Function[edit | edit source]

  • reaction:
    EC 5.3.1.26?  ExPASy
    Galactose-6-phosphate isomerase D-galactose 6-phosphate = D-tagatose 6-phosphate
  • TIGRFAM:
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides galactose-6-phosphate isomerase, LacA subunit (TIGR01118; EC 5.3.1.26; HMM-score: 256.4)
    and 6 more
    sugar-phosphate isomerase, RpiB/LacA/LacB family (TIGR00689; EC 5.3.1.-; HMM-score: 115.2)
    Metabolism Energy metabolism Pentose phosphate pathway ribose 5-phosphate isomerase B (TIGR01120; EC 5.3.1.6; HMM-score: 104.6)
    ribose 5-phosphate isomerase (TIGR02133; EC 5.3.1.6; HMM-score: 89.9)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides galactose-6-phosphate isomerase, LacB subunit (TIGR01119; EC 5.3.1.26; HMM-score: 37.2)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, mannose/fructose/sorbose family, IIA component (TIGR00824; EC 2.7.1.69; HMM-score: 12.7)
    Signal transduction Signal transduction PTS PTS system, mannose/fructose/sorbose family, IIA component (TIGR00824; EC 2.7.1.69; HMM-score: 12.7)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    no clan defined LacAB_rpiB; Ribose/Galactose Isomerase (PF02502; HMM-score: 122.5)
    and 2 more
    NADP_Rossmann (CL0063) HcgC; FeGP cofactor biosynthesis protein, methyltransferase HcgC (PF06690; HMM-score: 15.5)
    GT-A (CL0110) CTP_transf_3; Cytidylyltransferase (PF02348; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002044
    • TAT(Tat/SPI): 0.000173
    • LIPO(Sec/SPII): 0.000226
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000029270 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSIVIGADAAGLRLKEVVKDFLEKENFHLVDVTAEGQDFVDVTLAVAAEVNKEEQNLGIVIDAYGAGPFIVATKIKGMVAAEVSDERSAYMTRSHNNSRMITMGAQLVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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