PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 24-JAN-2021

⊟Summary

• organism: Streptococcus pneumoniae CGSP14
• locus tag: SPCG_RS09700 [old locus tag: SPCG_1871 ]
• pan locus tag^?: PNEUPAN003395000
• symbol: SPCG_RS09700
• pan gene symbol^?: msmE
• synonym:
• product: extracellular solute-binding protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPCG_RS09700 [old locus tag: SPCG_1871 ]
• symbol: SPCG_RS09700
• product: extracellular solute-binding protein
• replicon: chromosome
• strand: -
• coordinates: 1854079..1855338
• length: 1260
• essential: unknown

⊟Accession numbers

• Location: NC_010582 (1854079..1855338) NCBI
• BioCyc: SPCG_RS09700 BioCyc
• MicrobesOnline: see SPCG_1871
• PneumoBrowse for strain D39V: SPV_1677 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  
  ATGGAATGGTATAAAAAAATCGGACTTCTTGCAACTACAGGTTTAGCTTTGTTTGGGCTC
  GGCGCTTGCTCCAACTATGGTAAATCTGCGGATGACACAGTGACCATCGAGTATTTCAAC
  CAGAAAAAAGAAATGACCAAAACCTTGGAAGAAATCACTCGTGATTTTGAGAAGGAAAAC
  CCTAAGATCAAGGTCAAAGTCGTCAATGTACCAAATGCTGGTGAAGTATTGAAGACACGC
  GTTCTCGCAGGAGATGTGCCTGATGTGGTCAATATTTACCCACAGTCCATCGAACTGCAA
  GAATGGGCAAAAGCAGGTGTCTTTGAAGATTTGAGCAACAAAGACTACCTGAAACGCGTG
  AAAAATGGCTACGCTGAAAAATATGCTGTAAACGAAAAAGTTTACAACGTTCCTTTTACA
  GCTAATGCTTATGGAATTTACTACAACAAAGATAAATTCGAAGAACTGGGCTTGAAGGTT
  CCTGAAACCTGGGATGAATTTGAACAGTTAGTCAAAGATATCGTTGCTAAAGGACAAACA
  CCATTTGGAATTGCAGGTGCAGATGCTTGGACACTCAATGGTTACAATCAATTAGCCTTT
  GCGACAGCAACAGGTGGAGGAAAAGAAGCAAATCAATACCTTCGTTATTCTCAACCAAAT
  GCCATTAAATTGTCGGATCCGATTATGAAAGATGATATCAAGGTCATGGACATCCTTCGC
  ATCAATGGCTCTAAGCAAAAGAACTGGGAAGGTGCTGGCTATACCGATGTTATCGGAGCC
  TTCGCACGTGGGGATGTCCTCATGACACCAAATGGGTCTTGGGCGATCACAGCGATTAAT
  GAACAAAAACCGAACTTTAAGATTGGGACCTTCATGATTCCAGGAAAAGAAAAAGGACAA
  AGCTTAACCGTTGGTGCGGGAGACTTGGCATGGTCTATCTCAGCCACCACCAAACATCCA
  AAAGAAGCCAATGCCTTTGTGGAATATATGACCCGTCCAGAAGTCATGCAAAAATACTAC
  GATGTGGACGGATCTCCAACAGCGATCGAAGGGGTCAAACAAGCAGGAGAAGATTCACCG
  CTTGCTGGTATGACCGAATATGCCTTTACGGATCGTCACTTGGTCTGGTTGCAACAATAT
  TGGACCAGTGAAGCAGACTTCCATACCTTGACCATGAACTATGTCTTGACCGGTGATAAA
  CAAGGCATGGTCAATGATTTGAATGCCTTCTTTAACCCGATGAAAGCGGATGTGGATTAG
  60
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  1020
  1080
  1140
  1200
  1260
  

⊟Protein

⊟General

• locus tag: SPCG_RS09700 [old locus tag: SPCG_1871 ]
• symbol: SPCG_RS09700
• description: extracellular solute-binding protein
• length: 419
• theoretical pI: 4.85615
• theoretical MW: 46718.5
• GRAVY: -0.421718

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein (TIGR03851; HMM-score: 83)
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids carbohydrate ABC transporter substrate-binding protein, CPR_0540 family (TIGR03850; HMM-score: 67.2)
• TheSEED: see SPCG_1871
• PFAM:
  PBP (CL0177) SBP_bac_1; Bacterial extracellular solute-binding protein (PF01547; HMM-score: 146)
  SBP_bac_8; Bacterial extracellular solute-binding protein (PF13416; HMM-score: 145.3)
  and 3 more
  SBP_bac_6; Bacterial extracellular solute-binding protein (PF13343; HMM-score: 34.2)
  SBP_bac_11; Bacterial extracellular solute-binding protein (PF13531; HMM-score: 21.9)
  no clan defined ACP_PD; Acyl carrier protein phosphodiesterase (PF04336; HMM-score: 12.5)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• SignalP: Signal peptide LIPO(Sec/SPII) length 22 aa
  • SP(Sec/SPI): 0.002885
  • TAT(Tat/SPI): 0.000184
  • LIPO(Sec/SPII): 0.996441
  • Cleavage Site: CS pos: 22-23. LGA-CS. Pr: 0.9971
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000455411 NCBI
• UniProt: see SPCG_1871

⊟Protein sequence

• MEWYKKIGLLATTGLALFGLGACSNYGKSADDTVTIEYFNQKKEMTKTLEEITRDFEKENPKIKVKVVNVPNAGEVLKTRVLAGDVPDVVNIYPQSIELQEWAKAGVFEDLSNKDYLKRVKNGYAEKYAVNEKVYNVPFTANAYGIYYNKDKFEELGLKVPETWDEFEQLVKDIVAKGQTPFGIAGADAWTLNGYNQLAFATATGGGKEANQYLRYSQPNAIKLSDPIMKDDIKVMDILRINGSKQKNWEGAGYTDVIGAFARGDVLMTPNGSWAITAINEQKPNFKIGTFMIPGKEKGQSLTVGAGDLAWSISATTKHPKEANAFVEYMTRPEVMQKYYDVDGSPTAIEGVKQAGEDSPLAGMTEYAFTDRHLVWLQQYWTSEADFHTLTMNYVLTGDKQGMVNDLNAFFNPMKADVD

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: SPCG_RS13465 < SPCG_RS09690 < SPCG_RS09695 < SPCG_RS09700 < SPCG_RS09705

⊟Regulation

• regulator: CcpA see SPCG_1871

⊟Expression data

• PneumoExpress for strain D39V: SPV_1677 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications