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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_1078 [new locus tag: SPD_RS05770 ]
  • pan locus tag?: PNEUPAN002487000
  • symbol: ldh
  • pan gene symbol?: ldh
  • synonym:
  • product: L-lactate dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_1078 [new locus tag: SPD_RS05770 ]
  • symbol: ldh
  • product: L-lactate dehydrogenase
  • replicon: chromosome
  • strand: +
  • coordinates: 1105657..1106643
  • length: 987
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGACTTCAACTAAACAACACAAAAAAGTTATCCTTGTCGGTGATGGTGCTGTAGGTTCA
    TCTTACGCTTTTGCACTTGTTAACCAAGGAATTGCACAAGAGCTTGGAATTATCGAAATT
    CCACAATTGCATGAAAAAGCTGTTGGTGATGCGCTTGACCTTAGTCACGCCCTTGCCTTC
    ACTTCACCTAAAAAAATCTATGCAGCTCAATACTCTGACTGTGCAGACGCTGACCTTGTT
    GTAATCACTGCAGGTGCACCTCAAAAACCAGGTGAAACTCGTCTTGACCTTGTAGGTAAA
    AACCTTGCTATCAACAAATCAATCGTAACTCAAGTTGTTGAATCTGGTTTCAAAGGTATC
    TTCCTTGTTGCTGCTAACCCAGTTGACGTTTTGACTTACTCAACTTGGAAATTCTCTGGT
    TTCCCTAAAGAACGCGTTATCGGTTCAGGTACTTCACTTGACTCAGCTCGTTTCCGTCAA
    GCACTTGCTGAAAAATTGGATGTGGATGCTCGTTCAGTGCACGCCTACATCATGGGTGAA
    CACGGTGACTCTGAGTTCGCTGTTTGGTCACACGCTAACATCGCTGGTGTAAACCTTGAA
    GAATTCCTTAAAGACACTCAAAATGTTCAAGAAGCTGAATTGATTGAATTGTTCGAAGGT
    GTTCGTGATGCAGCCTACACAATCATCAACAAAAAAGGTGCAACATACTACGGTATCGCA
    GTAGCCCTTGCTCGTATCACTAAAGCAATCCTTGACGATGAAAACGCAGTACTTCCACTT
    TCAGTATTCCAAGAAGGTCAATACGGAGTTGAGAATGTCTTTATCGGTCAACCAGCTGTT
    GTTGGTGCACATGGTATCGTTCGTCCAGTAAACATTCCATTGAACGATGCAGAAACTCAA
    AAAATGCAAGCATCTGCTAAAGAATTGCAAGCTATTATTGACGAAGCATGGAAAAATCCA
    GAATTCCAAGAAGCTTCTAAAAACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    987

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_1078 [new locus tag: SPD_RS05770 ]
  • symbol: Ldh
  • description: L-lactate dehydrogenase
  • length: 328
  • theoretical pI: 4.86726
  • theoretical MW: 35354.8
  • GRAVY: -0.0192073

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.27?  ExPASy
    L-lactate dehydrogenase (S)-lactate + NAD+ = pyruvate + NADH
  • TIGRFAM:
    Metabolism Energy metabolism Anaerobic L-lactate dehydrogenase (TIGR01771; EC 1.1.1.27; HMM-score: 412.4)
    Metabolism Energy metabolism Glycolysis/gluconeogenesis L-lactate dehydrogenase (TIGR01771; EC 1.1.1.27; HMM-score: 412.4)
    and 7 more
    Metabolism Energy metabolism TCA cycle malate dehydrogenase, NAD-dependent (TIGR01763; EC 1.1.1.37; HMM-score: 227.2)
    malate dehydrogenase (TIGR01759; EC 1.1.1.-; HMM-score: 74.8)
    Metabolism Energy metabolism TCA cycle malate dehydrogenase, NAD-dependent (TIGR01772; EC 1.1.1.37; HMM-score: 73.6)
    lactate dehydrogenase (TIGR01756; EC 1.1.1.27; HMM-score: 51.8)
    malate dehydrogenase, NAD-dependent (TIGR01758; EC 1.1.1.37; HMM-score: 51.5)
    malate dehydrogenase, NADP-dependent (TIGR01757; EC 1.1.1.82; HMM-score: 19.6)
    Metabolism Amino acid biosynthesis Other pyrrolysine biosynthesis protein PylD (TIGR03911; HMM-score: 12.3)
  • TheSEED  :
    • L-lactate dehydrogenase (EC 1.1.1.27)
    Carbohydrates Fermentation Fermentations: Lactate  L-lactate dehydrogenase (EC 1.1.1.27)
    and 1 more
    Carbohydrates Fermentation Fermentations: Mixed acid  L-lactate dehydrogenase (EC 1.1.1.27)
  • PFAM:
    NADP_Rossmann (CL0063) Ldh_1_N; lactate/malate dehydrogenase, NAD binding domain (PF00056; HMM-score: 151.9)
    LDH_C (CL0341) Ldh_1_C; lactate/malate dehydrogenase, alpha/beta C-terminal domain (PF02866; HMM-score: 139.3)
    and 1 more
    no clan defined CRIC_ras_sig; Connector enhancer of kinase suppressor of ras (PF10534; HMM-score: 11.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.072007
    • TAT(Tat/SPI): 0.002961
    • LIPO(Sec/SPII): 0.002545
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTSTKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLHEKAVGDALDLSHALAFTSPKKIYAAQYSDCADADLVVITAGAPQKPGETRLDLVGKNLAINKSIVTQVVESGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALAEKLDVDARSVHAYIMGEHGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAELIELFEGVRDAAYTIINKKGATYYGIAVALARITKAILDDENAVLPLSVFQEGQYGVENVFIGQPAVVGAHGIVRPVNIPLNDAETQKMQASAKELQAIIDEAWKNPEFQEASKN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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