PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 05-APR-2025

⊟Summary

• organism: Streptococcus pneumoniae SPN994039
• locus tag: SPN994039_RS05815 [old locus tag: SPN994039_10810 ]
• pan locus tag^?: PNEUPAN002458000
• symbol: SPN994039_RS05815
• pan gene symbol^?: ldh
• synonym:
• product: L-lactate dehydrogenase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPN994039_RS05815 [old locus tag: SPN994039_10810 ]
• symbol: SPN994039_RS05815
• product: L-lactate dehydrogenase
• replicon: chromosome
• strand: +
• coordinates: 1106657..1107643
• length: 987
• essential: unknown

⊟Accession numbers

• Location: NC_021005 (1106657..1107643) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1078 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  
  ATGACTTCAACTAAACAACACAAAAAAGTTATCCTTGTCGGTGATGGTGCTGTAGGTTCA
  TCTTACGCTTTTGCACTTGTTAACCAAGGAATTGCACAAGAGCTTGGAATTATCGAAATT
  CCACAATTGCATGAAAAAGCTGTTGGTGATGCGCTTGACCTTAGTCACGCCCTTTCCTTC
  ACTTCACCTAAAAAAATCTATGCAGCTCAATACTCTGACTGTGCAGACGCTGACCTTGTT
  GTGATCACTGCAGGTGCACCTCAAAAACCAGGTGAAACTCGTCTTGACCTTGTAGGTAAA
  AACCTTGCTATCAACAAATCAATCGTAACTCAAGTTGTTGAATCTGGTTTCAAAGGTATC
  TTCCTTGTTGCTGCTAACCCAGTTGACGTTTTGACTTACTCAACTTGGAAATTCTCTGGT
  TTCCCTAAAGAACGCGTTATCGGTTCAGGTACTTCACTTGACTCAGCTCGTTTCCGTCAA
  GCACTTGCTGAAAAATTGGATGTGGATGCTCGTTCAGTGCACGCCTACATCATGGGTGAA
  CACGGTGACTCTGAGTTCGCTGTTTGGTCACACGCTAACATCGCTGGTGTAAACCTTGAA
  GAATTCCTTAAAGACACTCAAAATGTTCAAGAAGCTGAATTGATTGAATTGTTCGAAGGT
  GTTCGTGATGCAGCCTACACAATCATCAACAAAAAAGGTGCAACATACTACGGTATCGCA
  GTAGCCCTTGCTCGTATCACTAAAGCAATCCTTGACGATGAAAACGCAGTACTTCCACTT
  TCAGTATTCCAAGAAGGTCAATACGGAGTTGAGAATGTCTTTATCGGTCAACCAGCTGTT
  GTTGGTGCACATGGTATCGTTCGTCCAGTAAACATTCCATTGAACGATGCAGAAACTCAA
  AAAATGCAAGCATCTGCTAAAGAATTGCAAGCTATTATTGACGAAGCATGGAAAAATCCA
  GAATTCCAAGAAGCTTCTAAAAACTAA
  60
  120
  180
  240
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  360
  420
  480
  540
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  780
  840
  900
  960
  987
  

⊟Protein

⊟General

• locus tag: SPN994039_RS05815 [old locus tag: SPN994039_10810 ]
• symbol: SPN994039_RS05815
• description: L-lactate dehydrogenase
• length: 328
• theoretical pI: 4.86726
• theoretical MW: 35370.8
• GRAVY: -0.0271341

⊟Function

• reaction:
  EC 1.1.1.27?  ExPASy
  L-lactate dehydrogenase (S)-lactate + NAD⁺ = pyruvate + NADH
• TIGRFAM:
  Metabolism Energy metabolism Anaerobic L-lactate dehydrogenase (TIGR01771; EC 1.1.1.27; HMM-score: 412.7)
  Metabolism Energy metabolism Glycolysis/gluconeogenesis L-lactate dehydrogenase (TIGR01771; EC 1.1.1.27; HMM-score: 412.7)
  and 7 more
  Metabolism Energy metabolism TCA cycle malate dehydrogenase, NAD-dependent (TIGR01763; EC 1.1.1.37; HMM-score: 227.3)
  Metabolism Energy metabolism TCA cycle malate dehydrogenase, NAD-dependent (TIGR01772; EC 1.1.1.37; HMM-score: 73.7)
  malate dehydrogenase (TIGR01759; EC 1.1.1.-; HMM-score: 73.6)
  lactate dehydrogenase (TIGR01756; EC 1.1.1.27; HMM-score: 51)
  malate dehydrogenase, NAD-dependent (TIGR01758; EC 1.1.1.37; HMM-score: 50.4)
  malate dehydrogenase, NADP-dependent (TIGR01757; EC 1.1.1.82; HMM-score: 19.6)
  Metabolism Amino acid biosynthesis Other pyrrolysine biosynthesis protein PylD (TIGR03911; HMM-score: 12.3)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  NADP_Rossmann (CL0063) Ldh_1_N; lactate/malate dehydrogenase, NAD binding domain (PF00056; HMM-score: 151.3)
  LDH_C (CL0341) Ldh_1_C; lactate/malate dehydrogenase, alpha/beta C-terminal domain (PF02866; HMM-score: 139.3)
  and 1 more
  no clan defined CRIC_ras_sig; Connector enhancer of kinase suppressor of ras (PF10534; HMM-score: 11.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9141
  • Cytoplasmic Membrane Score: 0.0074
  • Cell wall & surface Score: 0.0021
  • Extracellular Score: 0.0764
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.075325
  • TAT(Tat/SPI): 0.003095
  • LIPO(Sec/SPII): 0.002595
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000204733 NCBI
• UniProt:

⊟Protein sequence

• MTSTKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLHEKAVGDALDLSHALSFTSPKKIYAAQYSDCADADLVVITAGAPQKPGETRLDLVGKNLAINKSIVTQVVESGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALAEKLDVDARSVHAYIMGEHGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAELIELFEGVRDAAYTIINKKGATYYGIAVALARITKAILDDENAVLPLSVFQEGQYGVENVFIGQPAVVGAHGIVRPVNIPLNDAETQKMQASAKELQAIIDEAWKNPEFQEASKN

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for D39V, TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_1078 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications