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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_1403 [new locus tag: SPD_RS07460 ]
  • pan locus tag?: PNEUPAN002957000
  • symbol: lytC
  • pan gene symbol?: lytC
  • synonym:
  • product: 1,4-beta-N-acetylmuramidase, putative

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_1403 [new locus tag: SPD_RS07460 ]
  • symbol: lytC
  • product: 1,4-beta-N-acetylmuramidase, putative
  • replicon: chromosome
  • strand: -
  • coordinates: 1422043..1423515
  • length: 1473
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    TTGAAAATAAAAATTGGATTAGCAAGTATCTGTTTACTAGGCTTGGCAACTAGTCATGTC
    GCTGCAAATGAAACTGAAGTAGCAAAAACTTCGCAGGATACAACGACAGCTTCAAGTAGT
    TCAGAGCAAAATCAGTCTTCTAATAAAACGCAAACGAGCGCAGAAGTACAGACTAATGCT
    GCTGCCTACTGGGATGGGGATTATTATGTAAAGGATGATGGTTCTAAAGCTCAAAGTGAA
    TGGATTTTTGACAACTACTATAAGGCTTGGTTTTATATTAATTCAGATGGTCGTTACTCG
    CAGAATGAATGGCATGGAAATTACTACCTGAAATCAGGTGGATATATGGCCCAAAACGAG
    TGGATCTATGACAGTAATTACAAGAGTTGGTTTTATCTCAAGTCAGATGGGGCTTATGCT
    CATCAAGAATGGCAATTGATTGGAAATAAGTGGTACTACTTCAAGAAGTGGGGTTACATG
    GCTAAAAGCCAATGGCAAGGAAGTTATTTCTTGAATGGTCAAGGAGCTATGATACAAAAT
    GAATGGCTCTATGATCCAGCTTATTCTGCTTATTTTTATCTAAAATCCGATGGAACTTAT
    GCTAACCAAGAGTGGCAAAAAGTGGGCGGCAAATGGTACTATTTCAAGAAGTGGGGCTAT
    ATGGCTCGGAATGAGTGGCAAGGCAACTACTATTTGACTGGAAGTGGTGCCATGGCGACT
    GACGAAGTGATTATGGATGGTGCTCGCTATATCTTTGCGGCCTCTGGTGAGCTCAAAGAA
    AAGAAAGATTTGAATGTCGGCTGGGTTCACAGAGATGGTAAACGCTATTTCTTTAATAAT
    AGAGAAGAACAAGTGGGAACCGAACATGCTAAGAAAATCATTGATATTAGTGAGCACAAT
    GGTCGTATCAATGATTGGAAAAAGGTTATTGATGAGAACGAGGTGGATGGTGTCATTGTT
    CGTCTAGGTTATAGCGGTAAAGAAGACAAGGAATTGGCGCATAACATTAAGGAGTTAAAC
    CGTCTGGGAATTCCTTATGGTGTCTATCTCTATACCTATGCTGAAAATGAGACCGATGCT
    GAGAATGACGCTAAACAGACCATTGAACTTATAAAGAAATACAATATGAACCTGTCTTAC
    CCTATCTATTATGATGTTGAGAACTGGGAATATGTAAATAAGAGCAAGAGAGCTCCAAGT
    GATACAGACACTTGGGTTAAAATCATCAACAAGTACATGGACACGATGAAGCAGGCGGGT
    TATCAAAATGTATATGTCTATAGCTATCGTAGTTTATTACAGACGCGTTTAAAACACCCA
    GATATTTTAAAACATGTAAACTGGGTAGCGGCCTATACGAATGCTTTAGAATGGGAAAAC
    CCTTATTATTCAGGAGAAAAAGGTTGGCAATATACCTCTTCTGAATACATGAAAGGAATC
    CAAGGGCGCGTAGATGTCAGCGTTTGGTATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1473

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_1403 [new locus tag: SPD_RS07460 ]
  • symbol: LytC
  • description: 1,4-beta-N-acetylmuramidase, putative
  • length: 490
  • theoretical pI: 6.26781
  • theoretical MW: 57402.2
  • GRAVY: -0.819184

⊟Function[edit | edit source]

  • reaction:
    EC 3.2.1.96?  ExPASy
    Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -(Man(GlcNAc)2)Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact
  • TIGRFAM:
    glucan-binding repeat (TIGR04035; HMM-score: 15.3)
  • TheSEED  :
    • Cell wall-associated murein hydrolase LytC
    Regulation and Cell signaling Programmed Cell Death and Toxin-antitoxin Systems Fratricide in Streptococcus  Cell wall-associated murein hydrolase LytC
  • PFAM:
    Glyco_hydro_tim (CL0058) Glyco_hydro_25; Glycosyl hydrolases family 25 (PF01183; HMM-score: 71.6)
    Choline_binding (CL0694) Choline_bind_2; Choline-binding repeat (PF19085; HMM-score: 66)
    and 3 more
    Choline_bind_3; Choline-binding repeat (PF19127; HMM-score: 34.1)
    Choline_bind_1; Putative cell wall binding repeat (PF01473; HMM-score: 33.6)
    no clan defined DUF1007; Protein of unknown function (DUF1007) (PF06226; HMM-score: 10.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Extracellular
    • Cytoplasmic Score: 0.24
    • Cytoplasmic Membrane Score: 0.05
    • Cellwall Score: 0.8
    • Extracellular Score: 8.91
    • Internal Helices: 0
  • SignalP: Signal peptide SP(Sec/SPI) length 22 aa
    • SP(Sec/SPI): 0.987931
    • TAT(Tat/SPI): 0.00068
    • LIPO(Sec/SPII): 0.010493
    • Cleavage Site: CS pos: 22-23. VAA-NE. Pr: 0.8117
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKIKIGLASICLLGLATSHVAANETEVAKTSQDTTTASSSSEQNQSSNKTQTSAEVQTNAAAYWDGDYYVKDDGSKAQSEWIFDNYYKAWFYINSDGRYSQNEWHGNYYLKSGGYMAQNEWIYDSNYKSWFYLKSDGAYAHQEWQLIGNKWYYFKKWGYMAKSQWQGSYFLNGQGAMIQNEWLYDPAYSAYFYLKSDGTYANQEWQKVGGKWYYFKKWGYMARNEWQGNYYLTGSGAMATDEVIMDGARYIFAASGELKEKKDLNVGWVHRDGKRYFFNNREEQVGTEHAKKIIDISEHNGRINDWKKVIDENEVDGVIVRLGYSGKEDKELAHNIKELNRLGIPYGVYLYTYAENETDAENDAKQTIELIKKYNMNLSYPIYYDVENWEYVNKSKRAPSDTDTWVKIINKYMDTMKQAGYQNVYVYSYRSLLQTRLKHPDILKHVNWVAAYTNALEWENPYYSGEKGWQYTSSEYMKGIQGRVDVSVWY

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Vegard Eldholm, Ola Johnsborg, Kristine Haugen, Hilde Solheim Ohnstad, Leiv Sigve Håvarstein
Fratricide in Streptococcus pneumoniae: contributions and role of the cell wall hydrolases CbpD, LytA and LytC.
Microbiology (Reading): 2009, 155(Pt 7);2223-2234
[PubMed:19389766] [WorldCat.org] [DOI] (P p)

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