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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_1412 [new locus tag: SPD_RS07505 ]
  • pan locus tag?: PNEUPAN002967000
  • symbol: codY
  • pan gene symbol?: codY
  • synonym:
  • product: GTP-sensing transcriptional pleiotropic repressor CodY

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_1412 [new locus tag: SPD_RS07505 ]
  • symbol: codY
  • product: GTP-sensing transcriptional pleiotropic repressor CodY
  • replicon: chromosome
  • strand: -
  • coordinates: 1430268..1431056
  • length: 789
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGGCACATTTATTAGAAAAAACTAGAAAAATTACATCAATTTTGAAACGCTCAGAGGAG
    CAGTTGCAGGATGAGCTCCCTTACAACGCTATTACGCGTCAGTTAGCGGATATTATTCAT
    TGCAATGCCTGCATTATCAATAGTAAGGGACGTCTGCTTGGCTATTTTATGCGTTATAAA
    ACAAATACAGATCGCGTAGAGCAATTCTTCCAAACTAAGATTTTCCCAGATGACTACGTT
    CAAGGGGCTAATATGATTTACGAAACAGAAGCAAACTTGCCTGTTGAGCATGATATGAGT
    ATTTTCCCTGTTGAGAGTAGAGATGATTTTCCAGATGGCTTGACGACTATTGCACCGATT
    CATGTATCGGGGATTCGCCTTGGTTCTTTGATTATTTGGCGTAATGATAAAAAATTCGAA
    GATGAGGACTTGGTTCTTGTTGAGATTGCCAGTACCGTTGTTGGGATTCAGCTTCTTAAC
    TTCCAACGTGAAGAAGATGAGAAAAATATTCGTCGTCGTACTGCTGTCACCATGGCGGTC
    AATACCCTTTCTTACTCCGAACTCCGTGCTGTTTCAGCAATTTTAGGGGAATTAAATGGA
    AATGAAGGGCAGTTGACTGCGTCAGTGATTGCAGATCGTATCGGAATCACTCGCTCTGTG
    ATTGTCAATGCTCTTCGTAAACTTGAGTCTGCGGGGATTATTGAAAGTCGCTCACTTGGA
    ATGAAGGGAACCTATCTTAAGGTCTTGATTTCAGATATTTTTGAAGAAGTGAAGAAAAGA
    GATTACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    789

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_1412 [new locus tag: SPD_RS07505 ]
  • symbol: CodY
  • description: GTP-sensing transcriptional pleiotropic repressor CodY
  • length: 262
  • theoretical pI: 5.46687
  • theoretical MW: 29755.9
  • GRAVY: -0.198855

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions GTP-sensing transcriptional pleiotropic repressor CodY (TIGR02787; HMM-score: 425.8)
    and 5 more
    Signal transduction Regulatory functions DNA interactions CRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 24.1)
    Unknown function General Rrf2 family protein (TIGR00738; HMM-score: 16.1)
    phosphonate utilization associated transcriptional regulator (TIGR03338; HMM-score: 14.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly SUF system regulator (TIGR02944; HMM-score: 13.1)
    Signal transduction Regulatory functions DNA interactions FeS assembly SUF system regulator (TIGR02944; HMM-score: 13.1)
  • TheSEED  :
    • GTP-sensing transcriptional pleiotropic repressor codY
    Conserved gene cluster associated with Met-tRNA formyltransferase  GTP-sensing transcriptional pleiotropic repressor codY
  • PFAM:
    GAF (CL0161) CodY; CodY GAF-like domain (PF06018; HMM-score: 246.3)
    and 23 more
    HTH (CL0123) HTH_CodY; CodY helix-turn-helix domain (PF08222; HMM-score: 119.5)
    MarR_2; MarR family (PF12802; HMM-score: 32.6)
    HTH_11; HTH domain (PF08279; HMM-score: 31.8)
    HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 25.5)
    HTH_20; Helix-turn-helix domain (PF12840; HMM-score: 24.6)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 24.3)
    MarR; MarR family (PF01047; HMM-score: 22.8)
    TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 22.3)
    Rrf2; Iron-dependent Transcriptional regulator (PF02082; HMM-score: 21.9)
    GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 19.7)
    HTH_5; Bacterial regulatory protein, arsR family (PF01022; HMM-score: 17.9)
    Ribosomal_S25; S25 ribosomal protein (PF03297; HMM-score: 17.6)
    HTH_36; Helix-turn-helix domain (PF13730; HMM-score: 17.6)
    HTH_IclR; IclR helix-turn-helix domain (PF09339; HMM-score: 15.5)
    HTH_27; Winged helix DNA-binding domain (PF13463; HMM-score: 15.4)
    GAF (CL0161) GAF_3; GAF domain (PF13492; HMM-score: 15.2)
    HTH (CL0123) Cdc6_C; CDC6, C terminal winged helix domain (PF09079; HMM-score: 13.1)
    RPA_C; Replication protein A C terminal (PF08784; HMM-score: 12.5)
    HxlR; HxlR-like helix-turn-helix (PF01638; HMM-score: 12.3)
    HTH_29; Winged helix-turn helix (PF13551; HMM-score: 12.2)
    DUF4423; Domain of unknown function (DUF4423) (PF14394; HMM-score: 12)
    HTH_41; Helix-turn-helix domain (PF14502; HMM-score: 11.7)
    Acetyltrans (CL0257) Acetyltransf_8; Acetyltransferase (GNAT) domain (PF13523; HMM-score: 11.5)

⊟Structure, modifications & cofactors[edit | edit source]

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003435
    • TAT(Tat/SPI): 0.000298
    • LIPO(Sec/SPII): 0.000554
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MAHLLEKTRKITSILKRSEEQLQDELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGANMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLNFQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGQLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTYLKVLISDIFEEVKKRDY

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: CcpA regulon, CodY (activation (repression)) regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 
    CodY(TF)important in Amino acid metabolism; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Wouter T Hendriksen, Hester J Bootsma, Silvia Estevão, Theo Hoogenboezem, Anne de Jong, Ronald de Groot, Oscar P Kuipers, Peter W M Hermans
CodY of Streptococcus pneumoniae: link between nutritional gene regulation and colonization.
J Bacteriol: 2008, 190(2);590-601
[PubMed:18024519] [WorldCat.org] [DOI] (I p)Stéphanie Caymaris, Hester J Bootsma, Bernard Martin, Peter W M Hermans, Marc Prudhomme, Jean-Pierre Claverys
The global nutritional regulator CodY is an essential protein in the human pathogen Streptococcus pneumoniae.
Mol Microbiol: 2010, 78(2);344-60
[PubMed:20979332] [WorldCat.org] [DOI] (I p)Tobias Härtel, Eva Eylert, Christian Schulz, Lothar Petruschka, Philipp Gierok, Stephanie Grubmüller, Michael Lalk, Wolfgang Eisenreich, Sven Hammerschmidt
Characterization of central carbon metabolism of Streptococcus pneumoniae by isotopologue profiling.
J Biol Chem: 2012, 287(6);4260-74
[PubMed:22167202] [WorldCat.org] [DOI] (I p)

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