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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_1777 [new locus tag: SPD_RS09465 ]
  • pan locus tag?: PNEUPAN003573000
  • symbol: cbf1
  • pan gene symbol?: yhaM
  • synonym:
  • product: cmp-binding-factor 1

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_1777 [new locus tag: SPD_RS09465 ]
  • symbol: cbf1
  • product: cmp-binding-factor 1
  • replicon: chromosome
  • strand: -
  • coordinates: 1773456..1774409
  • length: 954
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGAGGAAGAATATGAAGATTAGTCACATGAAAAAAGATGAGCTATTTGAAGGCTTTTAC
    CTAATCAAATCAGCTGACCTGAGGCAAACTCGAGCTGGGAAAAACTACCTAGCCTTTACC
    TTCCAAGATGATAGTGGCGAGATTGATGGGAAGCTCTGGGATGCCCAACCTCATAACATT
    GAGGCCTTTACCGCAGGTAAGGTTGTCCACATGAAAGGACGCCGAGAAGTTTATAACAAT
    ACCCCTCAAGTCAATCAAATTACTCTCCGCCTGCCTCAAGCTGGTGAACCCAATGACCCA
    GCTGATTTCAAGGTCAAGTCACCAGTTGATGTCAAGGAAATTCGTGACTACATGTCGCAA
    ATGATTTTCAAAATTGAAAATCCTGTCTGGCAACGGATTGTCCGAAATCTCTACACCAAG
    TATGATAAGGAATTCTACTCCTATCCAGCTGCCAAGACCAACCACCATGCCTTTGAAACG
    GGCTTGGCCTATCATACGGCGACCATGGTGCGTTTGGCAGACGCTATTAGCGAAGTTTAT
    CCTCAGCTCAATAAGAGCCTGCTCTATGCGGGGATTATGTTGCACGACTTGGCTAAGGTC
    ATCGAGTTGACGGGACCAGACCAGACCGAGTACACGGTCAGAGGCAATCTTCTTGGACAT
    ATCGCTCTGATTGATAGCGAAATTACCAAGACAGTTATGGAACTCGGCATCGATGATACC
    AAGGAAGAAGTCGTTTTGCTTCGTCATGTCATCCTCAGTCACCACGGCTTGCTTGAATAT
    GGAAGTCCAGTCCGTCCACGTATTATGGAGGCAGAGATTATCCATATGATTGACAATCTG
    GATGCAAGCATGATGATGATGTCAACAGCTCTGGCTTTGGTGGATAAAGGAGAGATGTCC
    AATAAAATCTTCGCTATGGATAATCGTTCCTTCTATAAACCAGATTTAGATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    954

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_1777 [new locus tag: SPD_RS09465 ]
  • symbol: Cbf1
  • description: cmp-binding-factor 1
  • length: 317
  • theoretical pI: 6.51785
  • theoretical MW: 36301.5
  • GRAVY: -0.36183

⊟Function[edit | edit source]

  • TIGRFAM:
    integrating conjugative element relaxase, PFGI-1 class (TIGR03760; HMM-score: 14.7)
    HDIG domain (TIGR00277; HMM-score: 13.1)
    CRISPR-associated endonuclease Cas3-HD (TIGR01596; EC 3.1.-.-; HMM-score: 13)
  • TheSEED  :
    • 3'->5' exoribonuclease Bsu YhaM
  • PFAM:
    HD_PDEase (CL0237) HD; HD domain (PF01966; HMM-score: 25)
    OB (CL0021) tRNA_anti-codon; OB-fold nucleic acid binding domain (PF01336; HMM-score: 22.1)
    and 1 more
    HD_PDEase (CL0237) TraI_2; Putative helicase (PF07514; HMM-score: 13.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.012641
    • TAT(Tat/SPI): 0.001191
    • LIPO(Sec/SPII): 0.001594
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MRKNMKISHMKKDELFEGFYLIKSADLRQTRAGKNYLAFTFQDDSGEIDGKLWDAQPHNIEAFTAGKVVHMKGRREVYNNTPQVNQITLRLPQAGEPNDPADFKVKSPVDVKEIRDYMSQMIFKIENPVWQRIVRNLYTKYDKEFYSYPAAKTNHHAFETGLAYHTATMVRLADAISEVYPQLNKSLLYAGIMLHDLAKVIELTGPDQTEYTVRGNLLGHIALIDSEITKTVMELGIDDTKEEVVLLRHVILSHHGLLEYGSPVRPRIMEAEIIHMIDNLDASMMMMSTALALVDKGEMSNKIFAMDNRSFYKPDLD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: ComX1 regulon
    ComX1(sigma factor)controls the expression of late competence genes [1]   other strains

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Jelle Slager, Rieza Aprianto, Jan-Willem Veening
    Refining the Pneumococcal Competence Regulon by RNA Sequencing.
    J Bacteriol: 2019, 201(13);
    [PubMed:30885934] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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