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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 02-FEB-2021
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae D39
- locus tag: SPD_RS04815 [old locus tag: SPD_0895 ]
- pan locus tag?: PNEUPAN002094000
- symbol: hemH
- pan gene symbol?: hemH
- synonym:
- product: ferrochelatase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPD_RS04815 [old locus tag: SPD_0895 ]
- symbol: hemH
- product: ferrochelatase
- replicon: chromosome
- strand: +
- coordinates: 909638..910732
- length: 1095
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NC_008533 (909638..910732) NCBI
- BioCyc: G1G6V-990 BioCyc
- MicrobesOnline: see SPD_0895
- PneumoBrowse for strain D39V: SPV_0895 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1021
1081ATGAAAAAAGCAATTTTAATGATGACCTTCGGTTCACCAGAAGAGATTACCTTTGAAGGT
GTAGCTGATTTTTTCACAAATATTCGTCGTGGGGTGAGACCCCAAGACCACGAGATTCAG
ACTCTCTATGATAATTATGTACGAATTGGAGGCACGCCTCTGCAAAAAATTACCCGTCAA
GAGGTTACCTTGGTAGAAGCTAGGCTGGGGAATGAATACAGTGTCTACTTTGCTAATAAG
TTTTCCAGTCCCTTTATTCCAGATGTGATCGGTCAAATGGAAGCAGACGGAATTGAACAG
TGTATTTGCTTGATTTTGGAGCCCCATTATTCTTTCTACTCTGTCATGGGCTATGAAAAA
TTTTTAGAAAGCAAACAAATTCAATTTTTGGTCATTAAGGACTGGTATCAGGAAGAAGCG
CTCTTAAACTATTGGGCAGATGAAATTGCTAAGATTTTAAAAGAAGAAGTAAAGCAAGAC
AGCTTTAAAGTCATCTTTTCAGCCCATAGTGTGCCCATTTTTGCCTTGGACTTTGGTGAT
CCTTATATAGACCAAATTTTCGAAAATAGCAAGCTAGTCGCTGAAAAACTGGGCTTGAGT
TCAGAACAATATACCAACACTTGGCAGAGTGAGAGTGATATTGGTATTCCATGGATTAAA
CCAGATGTTTTGGAGTATCTCAGAGAACAGACAGAACATCCAGACCATTATATTTTTGTA
CCTATTAGTTTCATCAGTGAGCATATTGAGGTCTTGTTTGACAATGATGTAGAATGTTAT
GACTTATGCCAGGAATTTGGGGTAAACTACCATCGTCCACCAATGCCAAATACAGATTCT
CGTTTGATTGATGCTTTGGTCAATACAGTTAGAGTCAATGAAAATCAAGAGTTTAAGGAA
TTTCTCCCAGAAGAAGAGACCTTTGATGAGTTAGTTCCTTCAGACGAGACGAAAAACATT
TTAGCTGAATCTGAAGATTTACAAATGCCAGAATTTGTGAAAAAACTGATTGAGAAAAAA
GGGCGGGAGAATGTTAAGATGCCTTATCTTATCAAAAAAATGCTTGAAAAAGCAGGCAAG
TTACCCAAAGAGTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPD_RS04815 [old locus tag: SPD_0895 ]
- symbol: HemH
- description: ferrochelatase
- length: 364
- theoretical pI: 4.36034
- theoretical MW: 42455
- GRAVY: -0.369505
⊟Function[edit | edit source]
- reaction: EC 4.99.1.1? ExPASyProtoporphyrin ferrochelatase Protoheme + 2 H+ = protoporphyrin + Fe2+
- TIGRFAM: Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin ferrochelatase (TIGR00109; EC 4.99.1.1; HMM-score: 188.9)
- TheSEED: see SPD_0895
- PFAM: Chelatase (CL0043) Ferrochelatase; Ferrochelatase (PF00762; HMM-score: 221.3)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.016781
- TAT(Tat/SPI): 0.000173
- LIPO(Sec/SPII): 0.001166
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIGGTPLQKITRQEVTLVEARLGNEYSVYFANKFSSPFIPDVIGQMEADGIEQCICLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQDSFKVIFSAHSVPIFALDFGDPYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFVPISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKEFLPEEETFDELVPSDETKNILAESEDLQMPEFVKKLIEKKGRENVKMPYLIKKMLEKAGKLPKE
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: no polycistronic organisation predicted
⊟Regulation[edit | edit source]
- regulator: Rex* see SPD_0895
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0895 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
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