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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 09-NOV-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Taiwan19F-14
  • locus tag: SPT_RS05255 [old locus tag: SPT_1062 ]
  • pan locus tag?: PNEUPAN002094000
  • symbol: hemH
  • pan gene symbol?: hemH
  • synonym:
  • product: ferrochelatase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPT_RS05255 [old locus tag: SPT_1062 ]
  • symbol: hemH
  • product: ferrochelatase
  • replicon: chromosome
  • strand: +
  • coordinates: 1006697..1007791
  • length: 1095
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_012469 (1006697..1007791) NCBI
  • BioCyc: SPT_RS05255 BioCyc
  • MicrobesOnline: see SPT_1062
  • PneumoBrowse for strain D39V: SPV_0895 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    ATGAAAAAAGCCATATTAATGATGACCTTTGGATCTCCAGAGGAGATTAGTTTTGAAGGA
    GTAGCAGAATTCTTTACAAACATTCGTCGTGGAGTTAGACCCCAAGACCACGAAATCCAG
    ACTCTCTATGACAACTATATTCGTATCGGTGGGACGCCTTTGCAGCGGATTACACGTGAG
    GAGGTCAATTTAGTCAAAGAACGTTTAGGGGAGGAGTACGGTATCTACTTTGCCAACAAA
    TTTTCTCGTCCCTTTATTCCAGACGTGATCAAGCAGATGGAAACTGATGGTGTTGAAGAA
    TGTATCTGCTTGATTTTGGAACCTCATTATTCTTTTTACTCAGTCATGGGGTATGAAAAG
    TTTCTGGAAAGCCAGCAGATCCGATTTTTAGTTATTAAGGACTGGTATCAACAACAGTCT
    TTGCTGGACTTCTGGACAGATGAGATTAGAAAAATTTTACGAAATGAGGTGGGAGAAGAA
    TCCTTCAAGGTAATCTTTTCAGCCCATAGCGTTCCCATTTTTGCCTTGGACTATGGAGAT
    CCTTATATCGATCAGATTTTCGATAATAGCAGGCTCATTGCTGAACAACTAGGCCTAATG
    ACAGACCAGTATACCAATACTTGGCAGAGCGAAAGCGATATTGGAATCCCTTGGATCAAG
    CCAGATGTCTTAGAATATTTACGAGAACAAAAGCAACATCCAGAACATTATATTTTTGTT
    CCGATTAGCTTTATCAGTGAGCACATCGAAGTCTTGTTCGATAATGATGTGGAATGTTAT
    GATTTGTGTCAAGAATTAGGTGTCACTTACCATCGTCCACCGATGCCCAATACGGATAGC
    CGTTTAATTGACGCTTTAGTTGCTACTGTAAGAGCCAACGAAGACAAAGAATTTAAAACT
    TTTCTCCCAGAAGAAGAAACCTTTGATGAGTTAGCGCCTTCGGCAACTACCAAGGACATC
    ATGAAAGAGACAGACGACCTTCAGATGCCAGAATTTGTCAAAAAACTCATTGAGAAAAAA
    GGTCGTGAAAATGTTAAGATGCCTTATCTGATCAAGAAAATGCTTGAAAAAGCAGGCAAG
    TTACCCAAAGAGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1095

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPT_RS05255 [old locus tag: SPT_1062 ]
  • symbol: HemH
  • description: ferrochelatase
  • length: 364
  • theoretical pI: 4.51893
  • theoretical MW: 42782.6
  • GRAVY: -0.425275

⊟Function[edit | edit source]

  • reaction:
    EC 4.99.1.1?  ExPASy
    Protoporphyrin ferrochelatase Protoheme + 2 H+ = protoporphyrin + Fe2+
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin ferrochelatase (TIGR00109; EC 4.99.1.1; HMM-score: 172.4)
  • TheSEED: see SPT_1062
  • PFAM:
    Chelatase (CL0043) Ferrochelatase; Ferrochelatase (PF00762; HMM-score: 211.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.016355
    • TAT(Tat/SPI): 0.000191
    • LIPO(Sec/SPII): 0.001315
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKKAILMMTFGSPEEISFEGVAEFFTNIRRGVRPQDHEIQTLYDNYIRIGGTPLQRITREEVNLVKERLGEEYGIYFANKFSRPFIPDVIKQMETDGVEECICLILEPHYSFYSVMGYEKFLESQQIRFLVIKDWYQQQSLLDFWTDEIRKILRNEVGEESFKVIFSAHSVPIFALDYGDPYIDQIFDNSRLIAEQLGLMTDQYTNTWQSESDIGIPWIKPDVLEYLREQKQHPEHYIFVPISFISEHIEVLFDNDVECYDLCQELGVTYHRPPMPNTDSRLIDALVATVRANEDKEFKTFLPEEETFDELAPSATTKDIMKETDDLQMPEFVKKLIEKKGRENVKMPYLIKKMLEKAGKLPKE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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