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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 21-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_RS05085 [old locus tag: SPD_0945 ]
  • pan locus tag?: PNEUPAN002195000
  • symbol: SPD_RS05085
  • pan gene symbol?: menE
  • synonym:
  • product: AMP-binding protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_RS05085 [old locus tag: SPD_0945 ]
  • symbol: SPD_RS05085
  • product: AMP-binding protein
  • replicon: chromosome
  • strand: +
  • coordinates: 955180..956490
  • length: 1311
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGGAATTGTCGGAAATGATTAATAATGTGTTTGAAAGTTGTATACATCCTGAATATCAT
    TTTATTGATTTATCAAAGATAAAAGAGAATAGGATAGCAATTATAGGAGGAAATAAATCT
    GAGTATTTAAATTTAATCTTAAATCTTATGCTACAAGGTAAGGTTGTTATCCCTATTAAT
    CCGATCCAAACTAATTCTCAAATAGAAACACTTTTGAATTTGTCTGATGTTGAAGCAGTA
    TTAACAGATAATAGCTTTCAATGTAAAAGTGAGAAAAAAACGTATCTATTTTGTGAATTT
    AAACATATTTATAATAATCATGAAAGAGAGATTTCGGACACTCCTTTAGTGTTTTTTTCA
    TCAGGTACAACAGGAGTGCCTAAGCCGGTAATGATTAATAAATTAGCTTTTACAGAATTA
    ATTAATCTGATGATAGCACAGTTAGAAATATCTAGTGATGATGTGTTGTATCTCCCCTCC
    CACATTGCTTTCATTCAATCTCTCTGGGCTGCGATGATAGTAATTTTTTCGGGGGGAAGA
    GTAATTTTTAAAGATAGGATTACATATAAAACATTTTTTAAGGAACTTCAACTAAACGAT
    GCAACAATAACGGTTATGGTACCTACTACGATGAATAAACTTGTTAATTTATATACAAAT
    ACTCTCCAAGAGTGTAAAAAATTAAGATGTATTATTGTAGGTGGAGAGATTATAAATAAG
    GATAGTGCAAACTTTTTATTAAATAAATTGAAAAACACAAACATAGCAAATGCATATGGT
    ATGGTAGAGACAACCGCAGTTTGTTGTCTACAATATGGACGTGATTTAAAAAATATTAAC
    TCTGTTGGTACAACTCTACCGGGGGTTGAAGTTGAAGTAAAGAATATAGATAATGATGGT
    AATGGCGATATCTGGATAAAGACAAATCGCTTTATGAGCGGATATTACCCGAGTAAATAC
    ACTGGTGAATGGTTATATACAGGAGATAGAGGATATAAAAATAAGGAAGGACTTTTATTT
    GTAACAGGCCGTGAAAGTTTGTCAATTAATAAGGGAGGTATAAAAATTAATCCTATTGAA
    ATTGAACAGATTATTCTTCAATTGCCAGATATTCAACTTTGTAAAGTTGAAAAAATTAGT
    GATAATATTTACGGAGAAAATTATATATTAGAAGTTATTTCTGAAATTAAAGATAAAAAT
    AGAATAACAGGACAGATTTTAAAAAGCTTAGGTAAATATTATTTACCTGATTCAATAAAA
    TTTGTTGAGTCTATCGAAACAACTTCTAGTGGAAAATTGAAGAGAAATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1311

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_RS05085 [old locus tag: SPD_0945 ]
  • symbol: SPD_RS05085
  • description: AMP-binding protein
  • length: 436
  • theoretical pI: 6.66816
  • theoretical MW: 49372.8
  • GRAVY: -0.0986238

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone O-succinylbenzoate-CoA ligase (TIGR01923; EC 6.2.1.26; HMM-score: 164.7)
    and 12 more
    amino acid adenylation domain (TIGR01733; HMM-score: 122)
    acyl-CoA ligase (AMP-forming), exosortase A-associated (TIGR03098; HMM-score: 104.2)
    Metabolism Transport and binding proteins Cations and iron carrying compounds (2,3-dihydroxybenzoyl)adenylate synthase (TIGR02275; EC 2.7.7.58; HMM-score: 90.5)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan D-alanine--poly(phosphoribitol) ligase, subunit 1 (TIGR01734; EC 6.1.1.13; HMM-score: 82.2)
    benzoate-CoA ligase family (TIGR02262; HMM-score: 80.9)
    cyclohexanecarboxylate-CoA ligase (TIGR03208; EC 6.2.1.-; HMM-score: 73.5)
    dicarboxylate--CoA ligase PimA (TIGR03205; EC 6.2.1.23; HMM-score: 69.5)
    acetate--CoA ligase (TIGR02188; EC 6.2.1.1; HMM-score: 58.5)
    propionate--CoA ligase (TIGR02316; EC 6.2.1.17; HMM-score: 32.3)
    Metabolism Central intermediary metabolism Other acetoacetate-CoA ligase (TIGR01217; EC 6.2.1.16; HMM-score: 27.4)
    L-aminoadipate-semialdehyde dehydrogenase (TIGR03443; EC 1.2.1.31; HMM-score: 17.8)
    4-coumarate--CoA ligase (TIGR02372; EC 6.2.1.12; HMM-score: 13.7)
  • TheSEED: see SPD_0945
  • PFAM:
    ANL (CL0378) AMP-binding; AMP-binding enzyme (PF00501; HMM-score: 167.8)
    and 2 more
    AMP-binding_C (CL0531) AMP-binding_C; AMP-binding enzyme C-terminal domain (PF13193; HMM-score: 22.8)
    HTH (CL0123) BrxA; BrxA (PF08849; HMM-score: 16.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.5931
    • Cytoplasmic Membrane Score: 0.2114
    • Cell wall & surface Score: 0.0015
    • Extracellular Score: 0.1941
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003074
    • TAT(Tat/SPI): 0.000367
    • LIPO(Sec/SPII): 0.000619
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MELSEMINNVFESCIHPEYHFIDLSKIKENRIAIIGGNKSEYLNLILNLMLQGKVVIPINPIQTNSQIETLLNLSDVEAVLTDNSFQCKSEKKTYLFCEFKHIYNNHEREISDTPLVFFSSGTTGVPKPVMINKLAFTELINLMIAQLEISSDDVLYLPSHIAFIQSLWAAMIVIFSGGRVIFKDRITYKTFFKELQLNDATITVMVPTTMNKLVNLYTNTLQECKKLRCIIVGGEIINKDSANFLLNKLKNTNIANAYGMVETTAVCCLQYGRDLKNINSVGTTLPGVEVEVKNIDNDGNGDIWIKTNRFMSGYYPSKYTGEWLYTGDRGYKNKEGLLFVTGRESLSINKGGIKINPIEIEQIILQLPDIQLCKVEKISDNIYGENYILEVISEIKDKNRITGQILKSLGKYYLPDSIKFVESIETTSSGKLKRN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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