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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-FEB-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_RS09895 [old locus tag: SPD_1863 ]
  • pan locus tag?: PNEUPAN003812000
  • symbol: SPD_RS09895
  • pan gene symbol?: comGA
  • synonym:
  • product: GspE/PulE family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_RS09895 [old locus tag: SPD_1863 ]
  • symbol: SPD_RS09895
  • product: GspE/PulE family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1842091..1843032
  • length: 942
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_008533 (1842091..1843032) NCBI
  • BioCyc: G1G6V-2022 BioCyc
  • MicrobesOnline: see SPD_1863
  • PneumoBrowse for strain D39V: SPV_1863 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCAGCTCGGAAAAAAGGGACGCAGGAT
    ATCTATTTTGTCCCTAAGTTAGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGC
    TGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCGTTATCAGTCACTTTAAGTTT
    GTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
    TATGACCATAAGATAGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAG
    AGTTTGGTTATCCGTTTGTTGCACGATGAGGAGCAGGACCTGCATTTTTGGTTTCAGGAT
    ATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCTATCTTTTTGCTGGTCCGGTT
    GGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
    GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTG
    AACGAAGCAATCGGCCTAACCTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCA
    GATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGGCGCGTGCAGTGGTCAGAGCT
    AGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
    GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTC
    TGCTACCAGAGATTAATCGGGGGAGGAGGAATCGTTGACTTTGCAAGCAGAGATTATCAA
    GAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGCTTCTTAAAGATGGACATATC
    ACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    942

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_RS09895 [old locus tag: SPD_1863 ]
  • symbol: SPD_RS09895
  • description: GspE/PulE family protein
  • length: 313
  • theoretical pI: 6.13912
  • theoretical MW: 35555.2
  • GRAVY: -0.314377

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Pathogenesis type II secretion system protein E (TIGR02533; HMM-score: 144.2)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type II secretion system protein E (TIGR02533; HMM-score: 144.2)
    Cell structure Cell envelope Surface structures type IV-A pilus assembly ATPase PilB (TIGR02538; HMM-score: 122.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type IV-A pilus assembly ATPase PilB (TIGR02538; HMM-score: 122.8)
    and 20 more
    Cell structure Cell envelope Surface structures twitching motility protein (TIGR01420; HMM-score: 91.9)
    Cellular processes Cellular processes Chemotaxis and motility twitching motility protein (TIGR01420; HMM-score: 91.9)
    Genetic information processing Mobile and extrachromosomal element functions Plasmid functions plasmid transfer ATPase TraJ (TIGR02525; HMM-score: 62.9)
    P-type DNA transfer ATPase VirB11 (TIGR02788; HMM-score: 55.7)
    helicase/secretion neighborhood ATPase (TIGR03819; HMM-score: 52.1)
    Cellular processes Cellular processes Conjugation P-type conjugative transfer ATPase TrbB (TIGR02782; HMM-score: 50.3)
    Dot/Icm secretion system ATPase DotB (TIGR02524; HMM-score: 45.8)
    Cellular processes Cellular processes Sporulation and germination stage III sporulation protein AA (TIGR02858; HMM-score: 28.1)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking putative secretion ATPase, PEP-CTERM locus subfamily (TIGR03015; HMM-score: 23.8)
    Metabolism Central intermediary metabolism Nitrogen metabolism urease accessory protein UreG (TIGR00101; HMM-score: 17)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 15.2)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair checkpoint protein rad24 (TIGR00602; HMM-score: 14.5)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA threonylcarbamoyl adenosine modification protein YjeE (TIGR00150; HMM-score: 13.1)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 12.7)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 12.6)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent chaperone protein ClpB (TIGR03346; HMM-score: 12.6)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta' subunit (TIGR00678; EC 2.7.7.7; HMM-score: 11.9)
    Cellular processes Cellular processes Other gas vesicle protein GvpN (TIGR02640; HMM-score: 11.9)
    Cellular processes Cellular processes Pathogenesis type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 11.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 11.8)
  • TheSEED: see SPD_1863
  • PFAM:
    P-loop_NTPase (CL0023) T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 167.4)
    and 33 more
    AAA_14; AAA domain (PF13173; HMM-score: 22)
    Rad17; Rad17 P-loop domain (PF03215; HMM-score: 20.4)
    SRPRB; Signal recognition particle receptor beta subunit (PF09439; HMM-score: 20.3)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 19.5)
    AAA_18; AAA domain (PF13238; HMM-score: 18.5)
    AAA_22; AAA domain (PF13401; HMM-score: 17.9)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 17.7)
    AAA_23; AAA domain (PF13476; HMM-score: 17.7)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 16.1)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 15.3)
    dNK; Deoxynucleoside kinase (PF01712; HMM-score: 15.1)
    Zeta_toxin; Zeta toxin (PF06414; HMM-score: 15)
    AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 15)
    cobW; CobW/HypB/UreG, nucleotide-binding domain (PF02492; HMM-score: 14.9)
    AAA_2; AAA domain (Cdc48 subfamily) (PF07724; HMM-score: 14.6)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 14.5)
    AFG1_ATPase; AFG1-like ATPase (PF03969; HMM-score: 14.4)
    AAA_33; AAA domain (PF13671; HMM-score: 13.8)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 13.7)
    Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 13.7)
    ATP_bind_1; Conserved hypothetical ATP binding protein (PF03029; HMM-score: 13.4)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 13.3)
    AAA_25; AAA domain (PF13481; HMM-score: 13.1)
    AAA_30; AAA domain (PF13604; HMM-score: 13.1)
    NTPase_1; NTPase (PF03266; HMM-score: 13)
    NACHT; NACHT domain (PF05729; HMM-score: 12.7)
    PduV-EutP; Ethanolamine utilisation - propanediol utilisation (PF10662; HMM-score: 12.4)
    AAA_28; AAA domain (PF13521; HMM-score: 12.3)
    Herpes_TK; Thymidine kinase from herpesvirus (PF00693; HMM-score: 12.2)
    APS_kinase; Adenylylsulphate kinase (PF01583; HMM-score: 12.1)
    Spore_III_AA; Sporulation stage III, protein AA (PF19568; HMM-score: 12)
    AAA_PrkA; PrkA AAA domain (PF08298; HMM-score: 11.8)
    GTP_EFTU; Elongation factor Tu GTP binding domain (PF00009; HMM-score: 11.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.89
    • Cytoplasmic Membrane Score: 0.09
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003824
    • TAT(Tat/SPI): 0.000275
    • LIPO(Sec/SPII): 0.000446
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MVQEIAQEIIRSARKKGTQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYAYDHKIASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQVMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVYERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFASRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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