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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_0008 [new locus tag: SPG_RS00040 ]
  • pan locus tag?: PNEUPAN000363000
  • symbol: SPG_0008
  • pan gene symbol?: divIC
  • synonym: ftsB
  • product: septum formation initiator, putative

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_0008 [new locus tag: SPG_RS00040 ]
  • symbol: SPG_0008
  • product: septum formation initiator, putative
  • replicon: chromosome
  • strand: +
  • coordinates: 8778..9146
  • length: 369
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    ATGTCTAAAAATATTGTACAATTGAATAATTCTTTTATTCAAAATGAATACCAACGTCGT
    CGCTACCTGATGAAAGAACGACAAAAACGGAATCGTTTTATGGGGGGGGTATTGATTTTG
    ATTATGCTATTATTTATCTTGCCAACTTTTAATTTAGCGCAGAGTTATCAGCAATTACTC
    CAAAGACGTCAGCAATTAGCAGACTTGCAAACTCAGTATCAAACTTTGAGTGATGAAAAG
    GATAAGGAAACAGCATTTGCTACCAAGTTGAAAGATGAAGATTATGCTGCTAAATATACA
    CGAGCGAAGTACTATTATTCTAAGTCGAGGGAAAAAGTTTATACGATTCCTGACTTGCTT
    CAAAGGTGA
    60
    120
    180
    240
    300
    360
    369

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_0008 [new locus tag: SPG_RS00040 ]
  • symbol: SPG_0008
  • description: septum formation initiator, putative
  • length: 122
  • theoretical pI: 10.3171
  • theoretical MW: 14805
  • GRAVY: -0.790984

⊟Function[edit | edit source]

  • TIGRFAM:
    PfaB family protein (TIGR02816; HMM-score: 11.3)
    and 1 more
    SH3 domain protein (TIGR04211; HMM-score: 6.3)
  • TheSEED  :
    • Cell division protein DivIC (FtsB), stabilizes FtsL against RasP cleavage
    Bacterial Cell Division  Cell division protein DivIC (FtsB), stabilizes FtsL against RasP cleavage
    and 2 more
    Cell division-ribosomal stress proteins cluster  Cell division protein DivIC (FtsB), stabilizes FtsL against RasP cleavage
    RP Bacterial Cell Division  Cell division protein DivIC (FtsB), stabilizes FtsL against RasP cleavage
  • PFAM:
    FtsL (CL0225) DivIC; Septum formation initiator (PF04977; HMM-score: 66.5)
    and 7 more
    TPR (CL0020) DUF6377; Domain of unknown function (DUF6377) (PF19904; HMM-score: 15.9)
    no clan defined TERF2_RBM; Telomeric repeat-binding factor 2 Rap1-binding motif (PF16772; HMM-score: 13)
    DUF5564; Family of unknown function (DUF5564) (PF17719; HMM-score: 12.8)
    O-anti_assembly (CL0499) O-antigen_lig; O-antigen ligase like membrane protein (PF13425; HMM-score: 12.4)
    Wzy_C; O-Antigen ligase (PF04932; HMM-score: 12.2)
    no clan defined DUF6056; Family of unknown function (DUF6056) (PF19528; HMM-score: 12)
    SNARE-fusion (CL0445) Synaptobrevin; Synaptobrevin (PF00957; HMM-score: 9.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0001
    • Cytoplasmic Membrane Score: 0.9954
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0045
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.09145
    • TAT(Tat/SPI): 0.009393
    • LIPO(Sec/SPII): 0.002547
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACF56207 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSKNIVQLNNSFIQNEYQRRRYLMKERQKRNRFMGGVLILIMLLFILPTFNLAQSYQQLLQRRQQLADLQTQYQTLSDEKDKETAFATKLKDEDYAAKYTRAKYYYSKSREKVYTIPDLLQR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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