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TIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_0623
  • pan locus tag?:
  • symbol: SPG_0623
  • pan gene symbol?:
  • synonym:
  • product: elongation factor Tu family protein

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SPG_0623
  • symbol: SPG_0623
  • product: elongation factor Tu family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 615753..616832
  • length: 1080
  • essential: unknown

Accession numbers[edit | edit source]

  • Location: CP001015 (615753..616832) NCBI
  • BioCyc:
  • MicrobesOnline: 5755892 MicrobesOnline
  • PneumoBrowse for strain D39V:

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    GTGTTACAAAACTNCTTCGGTTTCTTTGGTTTGGAACGTCGTGAAATCCAAGAAGCCAAA
    GCGGGTGACTTGATTGCCGTTTCAGGTATGGAAGACATCTTTGTCGGTGAAACCATCACT
    CCGACAGATGCAGTAGAAGCTCTTCCAATCCTACACATCGATGAGCCAACTCTTCAAATG
    ACTTTCTTGGTCAACAACTCACCATTTGCTGGTAAAGAAGGTAAATGGGTAACCTCTCGT
    AAGGTGGAAGAACGCTTGCAGGCAGAATTGCAAACAGACGTTTCCCTTCGTGTTGACCCA
    ACTGATTCACCAGATAAATGGACTGTTTCAGGACGTGGAGAATTGCACTTGTCAATCCTT
    ATCGAAACAATGCGTCGTGAGGGCTATGAACTTCAAGTATCTCGTCCAGAAGTTATCGTA
    AAAGAAATCGACGGTGTTAAATGTGAACCATTTGAACGTGTACAAATCGACACTCCAGAA
    GAATACCAAGGGTCTGTTATCCAAAGCCTTTCTGAACGTAAAGGTGAAATGTTGGATATG
    ATTTCAACTGGTAATGGTCAAACTCGTTTGGTCTTCCTTGTTCCAGCGCGTGGTTTGATT
    GGATACTCAACTGAGTTCTTGTCAATGACTCGTGGTTACGGTATCATGAACCATACCTTC
    GACCAATACTTGCCATTGATTCCAGGGGAAATTGGTGGACGTCACCGTGGTGCCCTTGTT
    TCTATCGATGCTGGTAAGGCTACAACTTACTCAATCATGTCTATCGAAGAACGTGGTACG
    ATCTTTGTCAACCCAGGTACTGAGGTTTATGAAGGAATGATCATCGGTGAAAACTCTCGT
    GAAAATGACTTGACAGTTAACATCACGAAGGCAAAACAAATGACCAACGTTCGTTCAGCT
    ACTAAGGACCAAACAGCTGTTATCAAGACGCCTCGTATCTTGACACTTGAAGAGTCTCTT
    GAGTTCTTGAACGACGATGAGTACATGGAAGTAACGCCTGAGTCTATCCGTTTGCGTAAA
    CAAATCCTTAACAAAGCAGAGCGTGAGAAAGCTAACAAGAAGAAAAAATCAGCTGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SPG_0623
  • symbol: SPG_0623
  • description: elongation factor Tu family protein
  • length: 359
  • theoretical pI: 4.71883
  • theoretical MW: 40193.5
  • GRAVY: -0.398324

Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Adaptations to atypical conditions GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 536.3)
    Genetic information processing Protein synthesis Translation factors GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 536.3)
    Signal transduction Regulatory functions Other GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 536.3)
    and 3 more
    Genetic information processing Protein synthesis Translation factors translation elongation factor G (TIGR00484; HMM-score: 73.9)
    Genetic information processing Protein synthesis Translation factors translation elongation factor aEF-2 (TIGR00490; HMM-score: 59.7)
    Unknown function General elongation factor 4 (TIGR01393; EC 3.6.5.-; HMM-score: 28.8)
  • TheSEED  :
    • GTP-binding protein TypA/BipA
    Protein Metabolism Protein biosynthesis Universal GTPases  GTP-binding protein TypA/BipA
  • PFAM:
    EF-G_C (CL0437) EFG_C; Elongation factor G C-terminus (PF00679; HMM-score: 86.8)
    and 3 more
    EFG_III; Elongation Factor G, domain III (PF14492; HMM-score: 27.8)
    EFTPs (CL0575) GTP_EFTU_D2; Elongation factor Tu domain 2 (PF03144; HMM-score: 14.9)
    no clan defined GTP_EFTU_D4; Elongation factor Tu domain 4 (PF14578; HMM-score: 12.9)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9869
    • Cytoplasmic Membrane Score: 0.0005
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0126
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005838
    • TAT(Tat/SPI): 0.001862
    • LIPO(Sec/SPII): 0.001087
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACF56125 NCBI
  • UniProt:

Protein sequence[edit | edit source]

  • MLQNXFGFFGLERREIQEAKAGDLIAVSGMEDIFVGETITPTDAVEALPILHIDEPTLQMTFLVNNSPFAGKEGKWVTSRKVEERLQAELQTDVSLRVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEVIVKEIDGVKCEPFERVQIDTPEEYQGSVIQSLSERKGEMLDMISTGNGQTRLVFLVPARGLIGYSTEFLSMTRGYGIMNHTFDQYLPLIPGEIGGRHRGALVSIDAGKATTYSIMSIEERGTIFVNPGTEVYEGMIIGENSRENDLTVNITKAKQMTNVRSATKDQTAVIKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILNKAEREKANKKKKSAE

Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Expression & Regulation[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription[edit | edit source]

  • transcription start site:

Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]