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Xen35
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gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_0773 [new locus tag: SPG_RS03905 ]
  • pan locus tag?: PNEUPAN001830000
  • symbol: parE
  • pan gene symbol?: parE
  • synonym:
  • product: DNA topoisomerase IV, B subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_0773 [new locus tag: SPG_RS03905 ]
  • symbol: parE
  • product: DNA topoisomerase IV, B subunit
  • replicon: chromosome
  • strand: +
  • coordinates: 748434..750377
  • length: 1944
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    GTGTCAAAAAAGGAAATCAATATTAACAATTATAATGATGATGCTATTCAGGTGCTAGAA
    GGGTTGGATGCGGTCCGAAAACGTCCAGGGATGTATATTGGATCGACCGATGGCGCTGGT
    CTTCATCACCTAGTTTGGGAAATCGTTGATAATGCAGTCGATGAAGCCTTGTCTGGGTTT
    GGTGATCGTATTGATGTAACTATCAATAAAGACGGTAGTCTAACGGTTCAAGACCATGGA
    CGTGGGATGCCGACAGGTATGCACGCTATGGGAATTCCAACTGTTGAGGTTATCTTTACC
    ATTCTTCATGCCGGAGGGAAATTCGGTCAAGGTGGCTATAAGACATCAGGTGGACTTCAC
    GGAGTGGGTTCTTCCGTTGTTAACGCCCTTTCTAGCTGGTTAGAAGTTGAAATTACCCGT
    GATGGCGCAGTTTACAAGCAACGTTTTGAAAATGGTGGAAAACCTGTCATGACTTTGAAG
    AAAGTCGGTACAGCACCCAAGTCTAAAACAGGCACCAAAGTTACTTTTATGCCTGACGCG
    ACTATCTTTTCTACGACAGATTTCAAGTACAATACCATTTCAGAGCGCCTTAATGAATCA
    GCCTTTCTCTTGAAAAATGTGACCTTGTCTTTAACGGACAAGCGAACAGATGAAGCGATT
    GAGTTCCACTATGAGAATGGAGTACAAGATTTTGTTTCTTATCTCAACGAAGATAAGGAA
    ATCTTGACGCCAGTTCTTTACTTTGAAGGGGAAGACAATGGTTTTCAAGTGGAAGTAGCC
    CTCCAGTACAATGACGGATTCTCAGATAACATTCTATCCTTTGTCAATAACGTTCGCACC
    AAGGACGGTGGAACGCACGAGACAGGACTCAAGTCTGCCATTACCAAGGTCATGAATGAC
    TATGCACGTAAAACAGGTCTTCTCAAGGAAAAAGATAAAAACCTTGAAGGTTCAGACTAT
    CGTGAGGGACTAGCGGCCGTTCTTTCTATCTTAGTTCCTGAAGAACACTTGCAGTTTGAA
    GGACAGACCAAGGATAAACTAGGAAGCCCCCTAGCTCGCCCGGTTGTGGATGGAATAGTG
    GCTGATAAGTTGACCTTTTTCCTTATGGAAAATGGGGAATTAGCTTCTAACCTCATCCGC
    AAGGCTATCAAGGCCCGTGATGCTCGTGAAGCAGCACGTAAGGCGCGTGATGAGAGCCGA
    AATGGGAAGAAAAACAAGAAAGATAAGGGCTTGTTGTCTGGGAAATTGACCCCAGCCCAA
    TCTAAGAATCCTGCTAAGAATGAACTCTATCTAGTTGAGGGGGACTCTGCCGGTGGTTCT
    GCCAAACAAGGTCGTGACCGCAAGTTCCAGGCTATTCTACCTCTTCGTGGTAAGGTTGTC
    AATACAGCCAAGGCCAAGATGGCGGATATCCTCAAAAATGAAGAGATCAATACCATGATT
    TATACCATTGGTGCGGGTGTTGGAGCAGACTTCTCTATTGAAGATGCCAACTATGATAAG
    ATCATTATCATGACCGATGCGGATACCGATGGTGCCCATATCCAGACCTTGCTCTTGACA
    TTTTTCTACCGTTACATGCGTCCGCTAGTCGAGGCAGGTCATGTCTATATTGCCCTCCCA
    CCTCTTTACAAGATGTCCAAAGGTAAAGGCAAGAAAGAAGAAGTGGCCTACGCTTGGACG
    GACGGAGAACTAGAAGAACTCCGTAAACAGTTCGGTAAAGGCGCTACCCTCCAACGATAC
    AAAGGACTTGGTGAGATGAATGCGGACCAGCTCTGGGAAACAACCATGAACCCAGAAACA
    CGTACCCTCATCCGTGTCACAATTGAAGATTTAGCGCGCGCCGAACGCCGCGTCAATGTT
    CTCATGGGAGATAAGGTAGAACCACGCCGTAAATGGATTGAAGATAATGTCAAGTTTACG
    CTAGAAGAAGCGACAGTGTTTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1944

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_0773 [new locus tag: SPG_RS03905 ]
  • symbol: ParE
  • description: DNA topoisomerase IV, B subunit
  • length: 647
  • theoretical pI: 6.61356
  • theoretical MW: 71650.9
  • GRAVY: -0.442195

⊟Function[edit | edit source]

  • reaction:
    EC 5.99.1.-?  ExPASy
  • ⊞TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA topoisomerase IV, B subunit (TIGR01058; EC 5.99.1.-; HMM-score: 1191.9)
    and 3 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA gyrase, B subunit (TIGR01059; EC 5.99.1.3; HMM-score: 869.5)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA topoisomerase IV, B subunit (TIGR01055; EC 5.99.1.-; HMM-score: 561.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone solanesyl diphosphate synthase (TIGR02749; EC 2.5.1.-; HMM-score: 11.8)
  • ⊞TheSEED  :
    • Topoisomerase IV subunit B (EC 5.99.1.-)
    DNA Metabolism DNA replication DNA topoisomerases, Type II, ATP-dependent  Topoisomerase IV subunit B (EC 5.99.1.-)
    and 1 more
    Virulence, Disease and Defense Resistance to antibiotics and toxic compounds Resistance to fluoroquinolones  Topoisomerase IV subunit B (EC 5.99.1.-)
  • ⊞PFAM:
    S5 (CL0329) DNA_gyraseB; DNA gyrase B (PF00204; HMM-score: 189.2)
    and 4 more
    no clan defined DNA_gyraseB_C; DNA gyrase B subunit, carboxyl terminus (PF00986; HMM-score: 102.5)
    His_Kinase_A (CL0025) HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 77.5)
    Toprim-like (CL0413) Toprim; Toprim domain (PF01751; HMM-score: 64.9)
    His_Kinase_A (CL0025) HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF13589; HMM-score: 12.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007057
    • TAT(Tat/SPI): 0.000365
    • LIPO(Sec/SPII): 0.000441
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACF56422 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSKKEININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGFGDRIDVTINKDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVMTLKKVGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYENGVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKDKNLEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARDESRNGKKNKKDKGLLSGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVVNTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTLEEATVF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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