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serotype 4
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HU-OH
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Hu15
serotype 19A
Hu17
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INV104
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INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
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serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_1107 [new locus tag: SPG_RS05585 ]
  • pan locus tag?: PNEUPAN002454000
  • symbol: SPG_1107
  • pan gene symbol?: cysD
  • synonym:
  • product: O-acetylhomoserine sulfhydrylase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_1107 [new locus tag: SPG_RS05585 ]
  • symbol: SPG_1107
  • product: O-acetylhomoserine sulfhydrylase
  • replicon: chromosome
  • strand: -
  • coordinates: 1085043..1086158
  • length: 1116
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    TTGAGGAAACCAGGGAACATTTATACTCGTATCACCAATCCTACAACAGCTGCCCTTGAA
    GGTGGTGTTGAAGCGCTAGCAACAGCATCAGGTATGACTGCAGTGACTTATACGATTTTG
    GCGCTTGCCCATGCTGGTGAGCATGTAGTGGCTGCTTCGACTATTTACGGTGGAACCTTC
    AATCTTTTGAAAAAACCCCTTCCTCGTTATGGTATCACAACAACCTTTGTCGATGTTGAT
    AATTTGGAGGAAGTAGAAGCAGCTATCAAAGACAATACCAAGCTTGTCTTGATTGAAACC
    TTGGGTAACCCCTTGATTAATATTCCAGACCTGGAAAAACTGGCAGAGATTGCTCATAAA
    CATCAAATCCCACTTGTGTCAGACAATACTTTTGCAACACCTTATTTGATNAACGTCTTC
    TCTCATGGCGTTGACATTGCCATTCACTCTGCGACTAAGTTTATCGGTGGGCATGGTACA
    ACTATTGGAGGAATAATTGTCGATAGTGGTCGTTTTGACTGGACGGCTTCAGGGAAATTC
    CCTCAATTTGTTGACGAGAGTCCAAGCTGCCACAATTTGAGATATACTCATGATGTGGGT
    GCAGCAGCCTTTATTATAGCTGTTCGAGTTCAATTGCTTCGTGATACAGGTGCAGCCTTG
    TCACCATTCAATGCTTTCCTCTTGCTACAAAGACTTGAAACCCTTTCACTTCGTGTGGAA
    CGCCATGTACAAAATGCTGAGACAATTGTTGATTTTCTTGTCAACCATCCTAAGGTAGAA
    AAGGTAAATTATCCAAAACTTGCAGATAGTCCTTATTATGCCTTGGCTGAGAAATACTTG
    CCAAAAGGTGTCGGTTCAATCTTTACCTTCCACGTCAAAGGCGACGAGGAGGAAGCACGC
    AAGGTCATTGATAATTTAGAAATCTTTTCTGACCTTGCAAACGCAGCAGATGCTAAATCG
    CTTGTTGTCCATCCAGCAACAATCACTCACGGTCAATTGTCAGAAAAAGACCTAGAAGCA
    GCAGGTGTCACACCAAATCAAATCCACTTGTCTATCGGTCTTGAAAATGTAGAAGATTTG
    ATTGAAGACTTACGCTTGGCCTTGGAAAAAATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1116

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_1107 [new locus tag: SPG_RS05585 ]
  • symbol: SPG_1107
  • description: O-acetylhomoserine sulfhydrylase
  • length: 371
  • theoretical pI: 5.68001
  • theoretical MW: 40200.5
  • GRAVY: 0.0432432

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aspartate family O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase (TIGR01326; HMM-score: 516.1)
    Metabolism Amino acid biosynthesis Serine family O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase (TIGR01326; HMM-score: 516.1)
    and 20 more
    Metabolism Amino acid biosynthesis Aspartate family O-succinylhomoserine sulfhydrylase (TIGR01325; EC 4.2.99.-; HMM-score: 325.3)
    Metabolism Energy metabolism Amino acids and amines methionine gamma-lyase (TIGR01328; EC 4.4.1.11; HMM-score: 315)
    Metabolism Amino acid biosynthesis Aspartate family O-succinylhomoserine (thiol)-lyase (TIGR02080; EC 2.5.1.48; HMM-score: 248.1)
    cystathionine beta-lyase (TIGR01329; EC 4.4.1.8; HMM-score: 204)
    Metabolism Amino acid biosynthesis Aspartate family cystathionine beta-lyase (TIGR01324; EC 4.4.1.8; HMM-score: 148.4)
    tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 23.8)
    Genetic information processing Protein synthesis tRNA and rRNA base modification cysteine desulfurase IscS (TIGR02006; EC 2.8.1.7; HMM-score: 23)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase IscS (TIGR02006; EC 2.8.1.7; HMM-score: 23)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase, SufS family (TIGR01979; HMM-score: 21.5)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01976; HMM-score: 21.3)
    Metabolism Energy metabolism Amino acids and amines tyrosine aminotransferase (TIGR01264; EC 2.6.1.5; HMM-score: 21.2)
    Unknown function Enzymes of unknown specificity uncharacterized pyridoxal phosphate-dependent enzyme (TIGR01437; HMM-score: 20.2)
    cysteine desulfurase, NifS family (TIGR03403; EC 2.8.1.7; HMM-score: 18.6)
    putative C-S lyase (TIGR04350; EC 4.4.-.-; HMM-score: 17.7)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 17.3)
    O-phospho-L-seryl-tRNA:Cys-tRNA synthase (TIGR02539; EC 2.5.1.73; HMM-score: 17.3)
    Genetic information processing DNA metabolism Restriction/modification cysteine desulfurase DndA (TIGR03235; EC 2.8.1.7; HMM-score: 16.6)
    cysteine desulfurase NifS (TIGR03402; EC 2.8.1.7; HMM-score: 16.5)
    UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase (TIGR03588; EC 2.6.1.92; HMM-score: 12.4)
    aminotransferase, LLPSF_NHT_00031 family (TIGR04181; HMM-score: 10.7)
  • TheSEED  :
    • O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)
    • O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Methionine Biosynthesis  O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)
    and 1 more
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Methionine Biosynthesis  O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)
  • PFAM:
    PLP_aminotran (CL0061) Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 388.2)
    and 5 more
    DegT_DnrJ_EryC1; DegT/DnrJ/EryC1/StrS aminotransferase family (PF01041; HMM-score: 35.4)
    Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 33.5)
    Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 29)
    SepSecS; O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS (PF05889; HMM-score: 16.5)
    Beta_elim_lyase; Beta-eliminating lyase (PF01212; HMM-score: 11.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.935
    • Cytoplasmic Membrane Score: 0.0078
    • Cell wall & surface Score: 0.0012
    • Extracellular Score: 0.0559
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.242687
    • TAT(Tat/SPI): 0.081367
    • LIPO(Sec/SPII): 0.010893
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACF55514 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MRKPGNIYTRITNPTTAALEGGVEALATASGMTAVTYTILALAHAGEHVVAASTIYGGTFNLLKKPLPRYGITTTFVDVDNLEEVEAAIKDNTKLVLIETLGNPLINIPDLEKLAEIAHKHQIPLVSDNTFATPYLXNVFSHGVDIAIHSATKFIGGHGTTIGGIIVDSGRFDWTASGKFPQFVDESPSCHNLRYTHDVGAAAFIIAVRVQLLRDTGAALSPFNAFLLLQRLETLSLRVERHVQNAETIVDFLVNHPKVEKVNYPKLADSPYYALAEKYLPKGVGSIFTFHVKGDEEEARKVIDNLEIFSDLANAADAKSLVVHPATITHGQLSEKDLEAAGVTPNQIHLSIGLENVEDLIEDLRLALEKI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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