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serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_1483 [new locus tag: SPG_RS07385 ]
  • pan locus tag?: PNEUPAN002842000
  • symbol: dapB
  • pan gene symbol?: dapB
  • synonym:
  • product: dihydrodipicolinate reductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_1483 [new locus tag: SPG_RS07385 ]
  • symbol: dapB
  • product: dihydrodipicolinate reductase
  • replicon: chromosome
  • strand: -
  • coordinates: 1431308..1432075
  • length: 768
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGAGTATTCGAGTAATTATTGCCGGTTTTAAGGGAAAGATGGGCCAGGCTGCTTGTCAG
    ATGGTATTGACTGATCCAGACTTGGACTTGGTGGCAGTTTTGGATCCTTTTGAGTCTGAG
    TCAGAATGGCAGGATATTCCTGTTTTCAAGGATAAGGCTGATTTAGCTGGTTTTGAAGCG
    GATGTCTGGGTAGATTTTACTACTCCAGCTGTTGCCTACGAAAATACACGTTTTGCTCTT
    GAAAATGGCTTTGCTCCAGTAGTTGGAACGACTGGTTTCACGAGTGAAGAAATTGCAGAG
    CTAAAAGAATTTTCTCGTGCCCAAGACTTGGGTGGCCTGATTGCCCCTAACTTTGCCTTG
    GGTGCTGTCTTACTCATGCAATTTGCGACGCAGGCTGCCAAATATTTCCCAAATGTGGAG
    ATTATTGAGCTCCATCATGACAAGAAAAAGGATGCTCCGAGTGGAACAGCCATTAAAACA
    GCTGAGTTGATGGCAGAGGTTCGAGAGTCCATTCAGCAAGGCGCAGCAGATGAGGAAGAG
    CTGATTGCTGGTGCTCGTGGTGCTGACTTTGATGGTATGCGCATCCACTCAGTTCGTTTG
    CCAGGTTTGGTAGCCCATCAGGAAGTCATCTTTGGCAATCAGGGAGAAGGGTTGACCCTC
    CGTCATGACTCCTATGATCGCATCTCCTTCATGACAGGAGTCAATTTGGGAATTAAAGAA
    GTTGTCAAGCGTCATGAGCTTGTCTATGGATTAGAACACTTATTATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    768

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_1483 [new locus tag: SPG_RS07385 ]
  • symbol: DapB
  • description: dihydrodipicolinate reductase
  • length: 255
  • theoretical pI: 4.4446
  • theoretical MW: 27894.5
  • GRAVY: -0.0160784

⊟Function[edit | edit source]

  • reaction:
    EC 1.17.1.8?  ExPASy
    4-hydroxy-tetrahydrodipicolinate reductase (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aspartate family 4-hydroxy-tetrahydrodipicolinate reductase (TIGR00036; EC 1.17.1.8; HMM-score: 246.1)
    and 2 more
    Metabolism Amino acid biosynthesis Aspartate family dihydrodipicolinate reductase (TIGR02130; EC 1.17.1.8; HMM-score: 22.8)
    diaminopimelate dehydrogenase (TIGR01921; EC 1.4.1.16; HMM-score: 15.1)
  • TheSEED  :
    • 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8)
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Lysine Biosynthesis DAP Pathway  4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8)
  • PFAM:
    GADPH_aa-bio_dh (CL0139) DapB_C; Dihydrodipicolinate reductase, C-terminus (PF05173; HMM-score: 112.2)
    NADP_Rossmann (CL0063) DapB_N; Dihydrodipicolinate reductase, N-terminus (PF01113; HMM-score: 107.7)
    and 1 more
    GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold (PF01408; HMM-score: 16.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9942
    • Cytoplasmic Membrane Score: 0.0002
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0056
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.019908
    • TAT(Tat/SPI): 0.000508
    • LIPO(Sec/SPII): 0.033249
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSIRVIIAGFKGKMGQAACQMVLTDPDLDLVAVLDPFESESEWQDIPVFKDKADLAGFEADVWVDFTTPAVAYENTRFALENGFAPVVGTTGFTSEEIAELKEFSRAQDLGGLIAPNFALGAVLLMQFATQAAKYFPNVEIIELHHDKKKDAPSGTAIKTAELMAEVRESIQQGAADEEELIAGARGADFDGMRIHSVRLPGLVAHQEVIFGNQGEGLTLRHDSYDRISFMTGVNLGIKEVVKRHELVYGLEHLL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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