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serotype 4
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serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
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serotype 6A
70585
serotype 5
A026
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serotype 11A
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serotype 23F
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CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_1786 [new locus tag: SPG_RS08940 ]
  • pan locus tag?: PNEUPAN003397000
  • symbol: msmR
  • pan gene symbol?: msmR
  • synonym:
  • product: msm operon regulatory protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_1786 [new locus tag: SPG_RS08940 ]
  • symbol: msmR
  • product: msm operon regulatory protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1723409..1724269
  • length: 861
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGTTAGTTTTTTCAGAATACCAGACTGGAACAATCGACCTTGCCCTAAGCTTTTATGGA
    TATGAGGAATGCACACCTAATTACTCTTTTGGTCCAGCCATTCGTGATACATACGTCCTA
    CATTACATTACTAAAGGACAAGGAAAATTTCATTACAAGGGTAAAATTGTTAATTTAAAA
    GAAGGAGATTTCTTTCTATTAAAACCAGAGGAACTAACCTTTTATCAAGCAGATAGTAAA
    GAACCTTGGGCCTACTACTGGTTAGGAATCACTGGAGGGAAATCCCCTGATTATTTTGCT
    CTTTCTCAAATTTCTGATCAATCCTATCTCATCCAATCTGAAACTTGTCATACCCAGACT
    ACTGCAAAACTCATCTCAGACATTGTCCGCTTCGCTCAGATTACAAAATCAAGTGAATTA
    GCTCAACTCCATATCATGGGACAACTTCATGAACTGATGTTTCATCTGGGAACTATTGCT
    CCCAATCAGAAAAAAAAGAATATTTCATCAACCCACCAACTCTATCTTGAATGCAAACGA
    TTAATTGATAGCCACTATCCTCAATCACTTACAATTCAAGATTTAGCAAAAGAACTATCC
    GTTCACAGAAGCTACTTATCAAGCGTATTCAAAGAATTTAATACCTTATCACCCAAAGAA
    TACCTACTCTACGTTCGAATGCACCGAGCTAGACAACTTCTCGAAAATACCCAAGAGTCC
    ATCAAGGTAATTGCATACTCGGTAGGTTTTTCAGATCCACTCCATTTTTCGAAAGCTTAT
    AAACAATACTTTAATCAGACTCCAAGTCATACAAGAAAAGAATACTCTCAATACCAACTA
    GTGAGAAAGGCAACATTATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    861

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_1786 [new locus tag: SPG_RS08940 ]
  • symbol: MsmR
  • description: msm operon regulatory protein
  • length: 286
  • theoretical pI: 8.83509
  • theoretical MW: 33217.6
  • GRAVY: -0.414336

⊟Function[edit | edit source]

  • TIGRFAM:
    4-hydroxyphenylacetate catabolism regulatory protein HpaA (TIGR02297; HMM-score: 62.5)
    and 4 more
    YSIRK-targeted surface antigen transcriptional regulator (TIGR04094; HMM-score: 47.5)
    Genetic information processing Mobile and extrachromosomal element functions Other addiction module antidote protein, HigA family (TIGR02607; HMM-score: 13.3)
    Signal transduction Regulatory functions DNA interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 13.3)
    Signal transduction Regulatory functions Protein interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 13.3)
  • TheSEED  :
    • MSM (multiple sugar metabolism) operon regulatory protein
    Carbohydrates Di- and oligosaccharides Fructooligosaccharides(FOS) and Raffinose Utilization  MSM (multiple sugar metabolism) operon regulatory protein
  • PFAM:
    Cupin (CL0029) AraC_binding; AraC-like ligand binding domain (PF02311; HMM-score: 102.4)
    HTH (CL0123) HTH_18; Helix-turn-helix domain (PF12833; HMM-score: 84.3)
    and 6 more
    HTH_AraC; Bacterial regulatory helix-turn-helix proteins, AraC family (PF00165; HMM-score: 65)
    Cupin (CL0029) Cupin_2; Cupin domain (PF07883; HMM-score: 16)
    HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 14.5)
    Ferritin (CL0044) DUF5623; Domain of unknown function (DUF5623) (PF18536; HMM-score: 12.6)
    HTH (CL0123) MarR; MarR family (PF01047; HMM-score: 12.2)
    no clan defined Focal_AT; Focal adhesion targeting region (PF03623; HMM-score: 11.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.026404
    • TAT(Tat/SPI): 0.000603
    • LIPO(Sec/SPII): 0.005464
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACF55958 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLVFSEYQTGTIDLALSFYGYEECTPNYSFGPAIRDTYVLHYITKGQGKFHYKGKIVNLKEGDFFLLKPEELTFYQADSKEPWAYYWLGITGGKSPDYFALSQISDQSYLIQSETCHTQTTAKLISDIVRFAQITKSSELAQLHIMGQLHELMFHLGTIAPNQKKKNISSTHQLYLECKRLIDSHYPQSLTIQDLAKELSVHRSYLSSVFKEFNTLSPKEYLLYVRMHRARQLLENTQESIKVIAYSVGFSDPLHFSKAYKQYFNQTPSHTRKEYSQYQLVRKATL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA* regulon
    CcpA*(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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