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Xen35
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gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_2069 [new locus tag: SPG_RS10360 ]
  • pan locus tag?: PNEUPAN003816000
  • symbol: SPG_2069
  • pan gene symbol?: ulaR2
  • synonym:
  • product: transcriptional regulator, BglG family

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_2069 [new locus tag: SPG_RS10360 ]
  • symbol: SPG_2069
  • product: transcriptional regulator, BglG family
  • replicon: chromosome
  • strand: -
  • coordinates: 1956542..1958167
  • length: 1626
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    ATGTTTGATTATAGAGCACTAGTTATTTTGATGACTTTGATGGATCATTGTGAGCTATCA
    TTATATGAATTATCTGTTAAGGTGAGCTTACCTATAAAGGAAGTCAAAGAAGGAATAGAT
    TATTTAGTGCCTTATCTAGCTAATAAAGGGATAGTGCTGGATAAAAAGCAAGGTCGCTAT
    AGTTTATCAAATCGTACGAAGCAGTCTTTGACAGATATTATTAAGTCGGATGAATTGGTT
    TTACCAAAGTCGACTCGCTTAGCTTTAATCTATCTTTACACTTTTTGCCGATTAGATTTT
    ATATCGAATAATCATTACCAAGACTTTTTGAAAGTAAGTAAGAATACAACCTTATCTGAT
    ATTCAATCATTAAGAAAGATTATGTTAGATAATGATTTGGAGCTAGGGTACAGTAGAGCA
    AAAGGTTATACTTTACACGGTTCAGAGTGGAATAAGCACCGCTTAGCTTTTCAAATGGTT
    AGTGAGTTGCTGGAATCCTCCATAGGGATTTGGGGTTTGGATTATGTTTTATCCAGTTGG
    GGGTATTCATTAACTTATGATTTGATTGATCAGGTAGTTAAAGATTATTATGAGAAGCTA
    CAGCTAGTACCTATTGTTAATCAATTAAAAGTTTACCTTTTCGGTTTAGTATTCATTCTG
    TGTAGGTATCAAAGGGATGTTGAAAGAGTATGTCTTTCAGAGACATTAGTATCTCCTGTT
    ATTCAAGATATAACCACTATTTTATTGGATACAGTGGTTGATTTGGGAATTATAGATACG
    GTGTTTTCTGAGGATGATTATCGCTATATCACCGTTTTATTATCAAGTTGCTTTGAAGGT
    GAAGTAGATGTTGCTCCGGTTTACTTTAATCAATTAACAGAGGCTATTATAAGTAGAATG
    GAAGATATTTCTTTGTTACATTTTAAACAAAGGGAAGGATTGAGAGAAAATCTTCGCCGC
    CACCTTATACCGGCTTACTATAGATTAAAGTTCGGCCTACCTAGTTCAAATGAATATGTA
    TTGCATGTTAAAGAACATTATCCTGATTTATTTGAATTAGTCAAAGATTCTTTGATGCCC
    TTGATGGACGCTATTGACAATCCCATACCTGATAGTGAAACAGCATATTTTGTTATCCAT
    TTCGGAGGTTATTTAAAGAAAGCAGATACTTTGCCTCAAAAATGCTATAAAGCAGCAATC
    ATTTGTCCTAATGGTGTTAGTTCTTCATTGATGTTAAAAGAGAATCTATTAGCATTATTT
    CCTCAAATTGAGTTTATAGGAACCTCAAAGATTGATGATTTACAGGTGAAAGCTAGTAGT
    GACTATGATATGGTTTTTTCTACCATAAAGGTGGAGACAGAAAAGCCAAATTATCTAGTT
    TCGGTTATGATGACTGAAGAGCAAGCAATACAACTAGTAGAACTAGTGTTAAAAGATTTT
    CCGAATTTAGAGTATGGAGATTTTGAGATTGAACAAATCCTGAATATTGTCAAAAGATAT
    GGAATTATTACACAAGAATTGGAATTAAGATTGGCGTTAAAGAATTATCTTTACCAAAAA
    AATGATAGAAAGGAAATTGTACCAGTGCTAGAACAACTTATTACCAAAGCAAACCTATCA
    GGTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1626

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_2069 [new locus tag: SPG_RS10360 ]
  • symbol: SPG_2069
  • description: transcriptional regulator, BglG family
  • length: 541
  • theoretical pI: 4.91427
  • theoretical MW: 62442
  • GRAVY: 0.000554528

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED  :
    • Transcriptional regulator, BglG family
  • PFAM:
    PRD (CL0166) PRD; PRD domain (PF00874; HMM-score: 65.4)
    and 3 more
    Phosphatase (CL0031) PTS_IIB; PTS system, Lactose/Cellobiose specific IIB subunit (PF02302; HMM-score: 24.5)
    HTH (CL0123) Mga; Mga helix-turn-helix domain (PF05043; HMM-score: 20.6)
    HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain (PF08221; HMM-score: 15.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors: HPr, phosphocarrier protein; SgaB2, ascorbate-specific PTS system, EIIB component
  • gene regulated by UlaR2*, TF important in Ascorbate utilizationRegPrecise
    ulaR2*

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.6725
    • Cytoplasmic Membrane Score: 0.3097
    • Cell wall & surface Score: 0.001
    • Extracellular Score: 0.0169
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.038168
    • TAT(Tat/SPI): 0.000989
    • LIPO(Sec/SPII): 0.036982
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACF55170 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFDYRALVILMTLMDHCELSLYELSVKVSLPIKEVKEGIDYLVPYLANKGIVLDKKQGRYSLSNRTKQSLTDIIKSDELVLPKSTRLALIYLYTFCRLDFISNNHYQDFLKVSKNTTLSDIQSLRKIMLDNDLELGYSRAKGYTLHGSEWNKHRLAFQMVSELLESSIGIWGLDYVLSSWGYSLTYDLIDQVVKDYYEKLQLVPIVNQLKVYLFGLVFILCRYQRDVERVCLSETLVSPVIQDITTILLDTVVDLGIIDTVFSEDDYRYITVLLSSCFEGEVDVAPVYFNQLTEAIISRMEDISLLHFKQREGLRENLRRHLIPAYYRLKFGLPSSNEYVLHVKEHYPDLFELVKDSLMPLMDAIDNPIPDSETAYFVIHFGGYLKKADTLPQKCYKAAIICPNGVSSSLMLKENLLALFPQIEFIGTSKIDDLQVKASSDYDMVFSTIKVETEKPNYLVSVMMTEEQAIQLVELVLKDFPNLEYGDFEIEQILNIVKRYGIITQELELRLALKNYLYQKNDRKEIVPVLEQLITKANLSG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: UlaR2* regulon
    UlaR2*(TF)important in Ascorbate utilization; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Muhammad Afzal, Sulman Shafeeq, Oscar P Kuipers
Ascorbic acid-dependent gene expression in Streptococcus pneumoniae and the activator function of the transcriptional regulator UlaR2.
Front Microbiol: 2015, 6;72
[PubMed:25717320] [WorldCat.org] [DOI] (P e)

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