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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_0400 [new locus tag: SPH_RS01950 ]
  • pan locus tag?: PNEUPAN001032000
  • symbol: SPH_0400
  • pan gene symbol?: manL
  • synonym: manX
  • product: mannose-specific phosphotransferase system component iiab

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_0400 [new locus tag: SPH_RS01950 ]
  • symbol: SPH_0400
  • product: mannose-specific phosphotransferase system component iiab
  • replicon: chromosome
  • strand: -
  • coordinates: 352742..353731
  • length: 990
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGAGTATCGGAATCATTATTGCGAGCCACGGCGAATTTGCTGCGGGTATTCATCAGTCA
    GGATCTATGATCTTTGGTGAACAAGAAAAGGTTCAAGTTGTGACCTTTATGCCAAATGAA
    GGTCCTGATGATCTATACGCTAAGTTTAATAACGCTGTTGCTGCATTTGACGCAGAAGAT
    GAGGTTCTAGTTTTGGCTGACCTTTGGAGTGGTTCTCCATTTAACCAAGCTAGTCGCGTG
    ATGGGAGAAAATCCTGAGCGTAAGTTTGCCATCATCACAGGACTTAACTTACCGATGTTG
    ATTCAAGCCTACACAGAGCGCCTCATGGACGCTGCTGCAGGTGTAGAAAAAGTCGCTGCT
    AATATCATTAAAGAAGCCAAAGATGGCATCAAAGCTCTTCCAGAAGAGCTAAATCCAGTT
    GAAGAAGTTGCAAGCGCTGCAGCTGCTCCAGTTGCCCAAACTGCTATCCCAGAAGGAACT
    GTTATCGGAGACGGTAAATTGAAAATCAATCTTGCCCGTCTTGACACACGTCTACTTCAC
    GGTCAGGTTGCAACTGCTTGGACTCCAGATTCAAAAGCAAATCGTATCATCGTTGCTTCA
    GATAATGTGGCTAAAGACGACCTTCGTAAAGAATTGATTAAACAAGCAGCTCCAGGTAAT
    GTCAAGGCTAACGTGGTTCCAATTCAAAAACTGATTGAGATTTCAAAAGACCCACGTTTT
    GGAGAAACACATGCCCTTATCTTGTTTGAAACACCTCAAGATGCCCTTCGTGCCATCGAA
    GGCGGCGTGCCAATCAAGACTCTTAACGTTGGTTCTATGGCTCACTCAACAGGTAAAACA
    TTGGTCAATACCGTTTTGTCTATGGACAAAGAAGATGTTGCTACATTTGAAAAAATGCGT
    GACTTGGGTGTTGAATTTGATGTCCGTAAAGTACCAAATGATTCTAAAAAAGATTTGTTT
    GACTTGATTAACAAAGCCAATGTCAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    990

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_0400 [new locus tag: SPH_RS01950 ]
  • symbol: SPH_0400
  • description: mannose-specific phosphotransferase system component iiab
  • length: 329
  • theoretical pI: 4.91903
  • theoretical MW: 35443.4
  • GRAVY: -0.0793313

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, mannose/fructose/sorbose family, IIB component (TIGR00854; EC 2.7.1.69; HMM-score: 152.6)
    Signal transduction Signal transduction PTS PTS system, mannose/fructose/sorbose family, IIB component (TIGR00854; EC 2.7.1.69; HMM-score: 152.6)
    and 2 more
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, mannose/fructose/sorbose family, IIA component (TIGR00824; EC 2.7.1.69; HMM-score: 97.3)
    Signal transduction Signal transduction PTS PTS system, mannose/fructose/sorbose family, IIA component (TIGR00824; EC 2.7.1.69; HMM-score: 97.3)
  • TheSEED  :
    • PTS system, mannose-specific IIA component (EC 2.7.1.69)
    • PTS system, mannose-specific IIB component (EC 2.7.1.69)
    Carbohydrates Monosaccharides Mannose Metabolism  PTS system, mannose-specific IIB component (EC 2.7.1.69)
    and 2 more
    Cell Wall and Capsule Capsular and extracellular polysacchrides Sialic Acid Metabolism  PTS system, mannose-specific IIA component
    Cell Wall and Capsule Capsular and extracellular polysacchrides Sialic Acid Metabolism  PTS system, mannose-specific IIB component (EC 2.7.1.69)
  • PFAM:
    no clan defined PTSIIB_sorb; PTS system sorbose subfamily IIB component (PF03830; HMM-score: 167)
    and 2 more
    EDD (CL0245) EIIA-man; PTS system fructose IIA component (PF03610; HMM-score: 122.6)
    no clan defined Pro_Al_protease; Alpha-lytic protease prodomain (PF02983; HMM-score: 11.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.014909
    • TAT(Tat/SPI): 0.00058
    • LIPO(Sec/SPII): 0.003977
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSIGIIIASHGEFAAGIHQSGSMIFGEQEKVQVVTFMPNEGPDDLYAKFNNAVAAFDAEDEVLVLADLWSGSPFNQASRVMGENPERKFAIITGLNLPMLIQAYTERLMDAAAGVEKVAANIIKEAKDGIKALPEELNPVEEVASAAAAPVAQTAIPEGTVIGDGKLKINLARLDTRLLHGQVATAWTPDSKANRIIVASDNVAKDDLRKELIKQAAPGNVKANVVPIQKLIEISKDPRFGETHALILFETPQDALRAIEGGVPIKTLNVGSMAHSTGKTLVNTVLSMDKEDVATFEKMRDLGVEFDVRKVPNDSKKDLFDLINKANVK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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