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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 31-JAN-2014
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae Hungary19A-6
- locus tag: SPH_0456 [new locus tag: SPH_RS02215 ]
- pan locus tag?: PNEUPAN001124000
- symbol: SPH_0456
- pan gene symbol?: cps2B
- synonym: cps4B
- product: tyrosine-protein phosphatase CpsB
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPH_0456 [new locus tag: SPH_RS02215 ]
- symbol: SPH_0456
- product: tyrosine-protein phosphatase CpsB
- replicon: chromosome
- strand: +
- coordinates: 406348..407079
- length: 732
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Location: CP000936 (406348..407079) NCBI
- BioCyc: see SPH_RS02215
- MicrobesOnline: 5695305 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_0316 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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721ATGATAGACATCCATTCGCATATCGTTTTTGATGTAGATGACGGTCCCAAGTCAAGAGAG
GAAAGCAAGGCTCTCTTGGCAGAATCCTATAGGCAGGGGGTGCGAACCATTGTCTCTACC
TCTCACCGTCGCAAGGGCATGTTTGAAACTCCGGAAGAGAAGATAGCAGAAAACTTTCTT
CAGGTTCGGGAAATAGCTAAGGAAGTGGCGAGTGACTTGGTCATTGCTTACGGGGCTGAA
ATTTACTACACATCAGATGTTTTGGATAAGCTGGAAAAAAATCGGATTCCGACCCTCAAT
AATAGTCGTTATGCCTTGATAGAGTTTAGTATGAACACCCCTTATCGCGATATCCATAGT
GCCTTGAGTAAAATATTGATGTTGGGAATTACTCCAGTCATTGCCCACATTGAGCGCTAT
GATGCACTTGAAAATAATGAAAAACGCGTTCGAGAGCTGATCAATATGGGCTGTTACACG
CAAGTAAATAGTTCACATGTCCTCAAATCCAAACTTTTTGGAGAACGTTATAAATTCATG
AAAAAAAGAGCTCAGTATTTTTTGGAGCGTGACTTGGTTCATATCATTGCAAGTGATATG
CATAATGTGGACAGCAGACCTCCCCATATGGCAGAAGCATATGACCTTGTTTCCCAAAAA
TACGGAGAAGCGAAGGCTCAGGAACTTTTTATAGATAATCCTCGAAAAATTGTAATGGAT
CAACTAATTTAG60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPH_0456 [new locus tag: SPH_RS02215 ]
- symbol: SPH_0456
- description: tyrosine-protein phosphatase CpsB
- length: 243
- theoretical pI: 7.03379
- theoretical MW: 28139.1
- GRAVY: -0.419342
⊟Function[edit | edit source]
- reaction: EC 3.1.3.48? ExPASyProtein-tyrosine-phosphatase Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
- TIGRFAM:
- TheSEED :
- Tyrosine-protein phosphatase CpsB (EC 3.1.3.48)
Cell Wall and Capsule Capsular and extracellular polysacchrides Exopolysaccharide Biosynthesis Manganese-dependent protein-tyrosine phosphatase (EC 3.1.3.48)and 2 more - PFAM: Amidohydrolase (CL0034) CpsB_CapC; Capsular polysaccharide synthesis, CpsB/CapC (PF19567; HMM-score: 241.1)and 1 moreNADP_Rossmann (CL0063) ISPD_C; D-ribitol-5-phosphate cytidylyltransferase C-terminal domain (PF18706; HMM-score: 14)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9872
- Cytoplasmic Membrane Score: 0.0067
- Cell wall & surface Score: 0
- Extracellular Score: 0.0061
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.002442
- TAT(Tat/SPI): 0.000481
- LIPO(Sec/SPII): 0.000718
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRRKGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTSDVLDKLEKNRIPTLNNSRYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELINMGCYTQVNSSHVLKSKLFGERYKFMKKRAQYFLERDLVHIIASDMHNVDSRPPHMAEAYDLVSQKYGEAKAQELFIDNPRKIVMDQLI
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0316 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Judy K Morona, David C Miller, Renato Morona, James C Paton
The effect that mutations in the conserved capsular polysaccharide biosynthesis genes cpsA, cpsB, and cpsD have on virulence of Streptococcus pneumoniae.
J Infect Dis: 2004, 189(10);1905-13
[PubMed:15122528] [WorldCat.org] [DOI] (P p)