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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_0482 [new locus tag: SPH_RS02345 ]
  • pan locus tag?: PNEUPAN001210000
  • symbol: gnd
  • pan gene symbol?: gnd
  • synonym: gndA
  • product: 6-phosphogluconate dehydrogenase, decarboxylating

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_0482 [new locus tag: SPH_RS02345 ]
  • symbol: gnd
  • product: 6-phosphogluconate dehydrogenase, decarboxylating
  • replicon: chromosome
  • strand: +
  • coordinates: 437206..438630
  • length: 1425
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    ATGACAAAAGCTAACTTTGGTGTCGTAGGTATGGCCGTAATGGGTCGTAACCTTGCCCTT
    AATATTGAATCTCGTGGTTACACAGTTGCTATCTACAACCGTAGTAAAGAAAAAACTGAA
    GATGTAATTGCTTGCCATCCTGAAAAGAACTTTGTACCAAGCTATGACGTTGAAAGTTTT
    GTAAACTCAATCGAAAGACCTCGTCGTATCATGCTCATGGTTCAAGCTGGACCTGGTACA
    GATGCGACTATTCAAGCCCTTCTTCCACACCTTGACAAGGGTGATATCTTGATCGACGGA
    GGAAACACTTTCTACAAAGATACAATCCGTCGTAATGAAGAATTGGCAAACTCAGGTATC
    AACTTTATCGGTACTGGGGTTTCTGGTGGTGAAAAAGGTGCCCTTGAAGGTCCTTCTATC
    ATGCCTGGTGGACAAAAAGAAGCTTATGAATTGGTTGCGGATGTTCTTGAAGAAATCTCA
    GCTAAAGCACCAGAAGATGGCAAACCATGTGTGACTTACATCGGTCCTGATGGAGCTGGT
    CACTATGTGAAAATGGTTCACAACGGTATAGAGTATGGTGATATGCAATTGATCGCAGAA
    AGCTATGACTTGATGCAACACTTGCTAGGCCTTTCTGCAGAAGACATGGCTGAAATCTTT
    ACTGAGTGGAACAAGGGTGAATTGGACAGCTACTTGATCGAAATCACAGCTGATATCTTG
    AGCCGTAAAGATGATGAAGGTCAAGATGGACCAATCGTAGACTACATCCTTGATGCTGCA
    GGTAACAAGGGAACTGGTAAATGGACTAGCCAATCATCACTTGACCTTGGTGTACCATTG
    TCACTCATCACTGAGTCAGTATTTGCCCGTTACATTTCAACTTACAAAGAAGAACGTGTA
    CATGCTAGCAAGGTGCTTCCAAAACCAGCCGCCTTCAAATTTGAAGGAGACAAGGCTGAA
    TTGATTGAAAAAATCCGTCAAGCCCTTTACTTCTCAAAAATCATTTCATACGCACAAGGT
    TTTGCACAATTGCGTGTAGCTTCTAAAGAAAATAACTGGAACTTGCCATTTGCGGACATC
    GCATCTATCTGGCGTGATGGCTGTATCATCCGTTCTCGTTTCTTGCAAAAGATTACAGAT
    GCTTACAACCGTGATGCAGACCTTGCTAACCTTCTTTTGGATGAGTACTTCTTGGATGTT
    ACTGCTAAGTACCAACAAGCAGTGCGTGATATCGTAGCTCTTGCTGTTCAAGCTGGTGTG
    CCAGTGCCAACTTTCTCAGCAGCTATTACTTACTTTGATAGCTACCGTTCAGCTGACCTT
    CCAGCTAACTTGATCCAAGCGCAACGTGATTACTTTGGTGCCCACACTTACCAACGTAAA
    GACAAAGAAGGAACCTTCCACTACTCTTGGTATGACGAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1425

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_0482 [new locus tag: SPH_RS02345 ]
  • symbol: Gnd
  • description: 6-phosphogluconate dehydrogenase, decarboxylating
  • length: 474
  • theoretical pI: 4.7165
  • theoretical MW: 52621
  • GRAVY: -0.277215

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.44?  ExPASy
    Phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH
  • TIGRFAM:
    Metabolism Energy metabolism Pentose phosphate pathway 6-phosphogluconate dehydrogenase (decarboxylating) (TIGR00873; EC 1.1.1.44; HMM-score: 723.1)
    and 3 more
    Metabolism Energy metabolism Pentose phosphate pathway 6-phosphogluconate dehydrogenase (decarboxylating) (TIGR00872; EC 1.1.1.44; HMM-score: 222.5)
    2-hydroxy-3-oxopropionate reductase (TIGR01505; EC 1.1.1.60; HMM-score: 50.2)
    Metabolism Energy metabolism Amino acids and amines 3-hydroxyisobutyrate dehydrogenase (TIGR01692; EC 1.1.1.31; HMM-score: 44.1)
  • TheSEED  :
    • 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)
    Carbohydrates Central carbohydrate metabolism Entner-Doudoroff Pathway  6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)
    and 2 more
    Carbohydrates Central carbohydrate metabolism Pentose phosphate pathway  6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)
    Carbohydrates One-carbon Metabolism Formaldehyde assimilation: Ribulose monophosphate pathway  6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)
  • PFAM:
    6PGD_C (CL0106) 6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain (PF00393; HMM-score: 441.5)
    and 5 more
    NADP_Rossmann (CL0063) NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase (PF03446; HMM-score: 167)
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 14.4)
    2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 13.8)
    Shikimate_DH; Shikimate / quinate 5-dehydrogenase (PF01488; HMM-score: 12.9)
    NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus (PF01210; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8643
    • Cytoplasmic Membrane Score: 0.0075
    • Cell wall & surface Score: 0.0015
    • Extracellular Score: 0.1268
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.044714
    • TAT(Tat/SPI): 0.002729
    • LIPO(Sec/SPII): 0.024172
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTEDVIACHPEKNFVPSYDVESFVNSIERPRRIMLMVQAGPGTDATIQALLPHLDKGDILIDGGNTFYKDTIRRNEELANSGINFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEISAKAPEDGKPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAEIFTEWNKGELDSYLIEITADILSRKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSLDLGVPLSLITESVFARYISTYKEERVHASKVLPKPAAFKFEGDKAELIEKIRQALYFSKIISYAQGFAQLRVASKENNWNLPFADIASIWRDGCIIRSRFLQKITDAYNRDADLANLLLDEYFLDVTAKYQQAVRDIVALAVQAGVPVPTFSAAITYFDSYRSADLPANLIQAQRDYFGAHTYQRKDKEGTFHYSWYDEK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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