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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_0699 [new locus tag: SPH_RS03400 ]
  • pan locus tag?: PNEUPAN001533000
  • symbol: fba
  • pan gene symbol?: fba
  • synonym:
  • product: fructose-1,6-bisphosphate aldolase, class II

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_0699 [new locus tag: SPH_RS03400 ]
  • symbol: fba
  • product: fructose-1,6-bisphosphate aldolase, class II
  • replicon: chromosome
  • strand: +
  • coordinates: 646139..647020
  • length: 882
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGGCAATCGTTTCAGCAGAAAAATTTGTCCAAGCAGCCCGTGACAACGGTTATGCAGTT
    GGTGGATTTAACACAAACAACCTTGAGTGGACTCAAGCTATCTTGCGCGCAGCAGAAGCT
    AAAAAAGCTCCAGTTTTGATCCAAACTTCAATGGGTGCTGCTAAATACATGGGTGGTTAC
    AAAGTTGCTCGCAACTTGATCGCTAACCTTGTTGAATCAATGGGTATCACTGTACCAGTA
    GCTATCCACCTTGACCACGGTCACTACGAAGATGCACTTGAGTGTATCGAAGTTGGTTAT
    ACTTCAATCATGTTTGACGGTTCACACCTTCCAGTTGAAGAAAACCTTAAATTGGCTAAA
    GAAGTTGTTGAAAAAGCACACGCTAAAGGTATCTCAGTAGAAGCTGAAGTTGGTACTATC
    GGTGGTGAAGAAGACGGAATCATCGGTAAAGGTGAATTGGCTCCAATCGAAGACGCTAAA
    GCAATGGTTGAAACTGGTATCGACTTCTTGGCAGCTGGTATCGGTAACATCCACGGTCCT
    TACCCAGTAAACTGGGAAGGTCTTGACCTTGACCACTTGCAAAAATTGACAGAAGCTCTT
    CCAGGATTCCCAATCGTATTGCACGGTGGATCAGGTATTCCTGATGAGCAAATCCAAGCA
    GCTATCAAACTTGGTGTTGCCAAAGTTAACGTTAACACAGAATGCCAAATCGCATTCGCT
    AACGCAACTCGTAAATTTGCTCGTGACTACGAAGCAAACGAAGCAGAATACGACAAGAAA
    AAACTCTTCGACCCACGTAAATTCTTGGCTGACGGTGTAAAAGCTATCCAAGCATCGGTT
    GAAGAACGTATCGACGTATTCGGTTCAGAAGGTAAAGCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    882

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_0699 [new locus tag: SPH_RS03400 ]
  • symbol: Fba
  • description: fructose-1,6-bisphosphate aldolase, class II
  • length: 293
  • theoretical pI: 4.74308
  • theoretical MW: 31401.5
  • GRAVY: -0.078157

⊟Function[edit | edit source]

  • reaction:
    EC 4.1.2.13?  ExPASy
    Fructose-bisphosphate aldolase D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate
  • TIGRFAM:
    Metabolism Energy metabolism Glycolysis/gluconeogenesis fructose-1,6-bisphosphate aldolase, class II (TIGR01859; EC 4.1.2.13; HMM-score: 410.5)
    and 5 more
    Metabolism Energy metabolism Glycolysis/gluconeogenesis ketose-bisphosphate aldolase (TIGR00167; HMM-score: 303.3)
    class II aldolase, tagatose bisphosphate family (TIGR01858; EC 4.1.2.-; HMM-score: 207.7)
    fructose-bisphosphate aldolase, class II, Calvin cycle subtype (TIGR01521; EC 4.1.2.13; HMM-score: 148.2)
    Metabolism Energy metabolism Glycolysis/gluconeogenesis fructose-bisphosphate aldolase, class II (TIGR01520; EC 4.1.2.13; HMM-score: 112.6)
    glycosyl amidation-associated protein WbuZ (TIGR03572; HMM-score: 13.1)
  • TheSEED  :
    • Fructose-bisphosphate aldolase class II (EC 4.1.2.13)
    Carbohydrates Central carbohydrate metabolism Glycolysis and Gluconeogenesis  Fructose-bisphosphate aldolase class II (EC 4.1.2.13)
    and 1 more
    Carbohydrates One-carbon Metabolism Formaldehyde assimilation: Ribulose monophosphate pathway  Fructose-bisphosphate aldolase class II (EC 4.1.2.13)
  • PFAM:
    TIM_barrel (CL0036) F_bP_aldolase; Fructose-bisphosphate aldolase class-II (PF01116; HMM-score: 319.2)
    and 1 more
    CutC; CutC family (PF03932; HMM-score: 16.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.021749
    • TAT(Tat/SPI): 0.001773
    • LIPO(Sec/SPII): 0.001765
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGYKVARNLIANLVESMGITVPVAIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGELAPIEDAKAMVETGIDFLAAGIGNIHGPYPVNWEGLDLDHLQKLTEALPGFPIVLHGGSGIPDEQIQAAIKLGVAKVNVNTECQIAFANATRKFARDYEANEAEYDKKKLFDPRKFLADGVKAIQASVEERIDVFGSEGKA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: Rex* (repression) regulon, CcpA regulon
    Rex*(TF)important in Energy metabolism; RegPrecise 
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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