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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_1346 [new locus tag: SPH_RS06520 ]
  • pan locus tag?: PNEUPAN002471000
  • symbol: coaC
  • pan gene symbol?: coaC
  • synonym:
  • product: phosphopantothenoylcysteine decarboxylase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_1346 [new locus tag: SPH_RS06520 ]
  • symbol: coaC
  • product: phosphopantothenoylcysteine decarboxylase
  • replicon: chromosome
  • strand: +
  • coordinates: 1247629..1248180
  • length: 552
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGGCAAACATTCTCTTGGCTGTAACGGGTTCAATCGCCTCTTATAAGTCGGCAGATTTA
    GTCAGTTCTCTAAAAAAACAAGGCCATCAAGTCACTGTCTTAATGACTCAGGCTGCTACA
    GAGTTTATCCAACCTTTGACACTACAGGTACTCTCACAGAATCCTGTCCACTTGGATGTC
    ATGAAGGAACCCTATCCTGATCAGGTCAATCATATCGAACTTGGAAAAAAAGCAGATTTA
    TTTATCGTGGTACCTGCAACTGCTAACACTATTGCAAAACTAGCTCACGGATTTGCGGAC
    AACATGGTAACCAGTACAGCTCTAGCCCTACCAAGTCATATTCCCAAACTAATAGCTCCT
    GCTATGAATACAAAAATGTATGACCATCCAGTAACTCAGAATAATCTGAAAACATTAGAA
    ACCTACGGCTATCAGCTGATTGCTCCTAAGGAATCCCTACTAGCTTGTGGAGACCACGGA
    CGAGGAGCTTTAGCTGACCTCACAATTATTTTAGAAAGAATAAAGGAAACTATCGATGAA
    AAAACGCTCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    552

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_1346 [new locus tag: SPH_RS06520 ]
  • symbol: CoaC
  • description: phosphopantothenoylcysteine decarboxylase
  • length: 183
  • theoretical pI: 6.89028
  • theoretical MW: 19866
  • GRAVY: 0.0721311

⊟Function[edit | edit source]

  • reaction:
    EC 4.1.1.36?  ExPASy
    Phosphopantothenoylcysteine decarboxylase N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A phosphopantothenoylcysteine decarboxylase (TIGR02113; EC 4.1.1.36; HMM-score: 327.3)
    and 5 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase (TIGR00521; EC 4.1.1.36,6.3.2.5; HMM-score: 213.6)
    Metabolism Energy metabolism Electron transport archaeoflavoprotein AfpA (TIGR02699; HMM-score: 34.1)
    Unknown function General archaeoflavoprotein, MJ0208 family (TIGR02700; HMM-score: 33.9)
    Unknown function Enzymes of unknown specificity polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases (TIGR00421; EC 4.1.1.-; HMM-score: 25.3)
    Cellular processes Cellular processes Sporulation and germination dipicolinic acid synthetase, B subunit (TIGR02852; HMM-score: 22.7)
  • TheSEED  :
    • Phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36)
    Cofactors, Vitamins, Prosthetic Groups, Pigments Coenzyme A Coenzyme A Biosynthesis  Phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36)
  • PFAM:
    no clan defined Flavoprotein; Flavoprotein (PF02441; HMM-score: 162.6)
    and 1 more
    PBP (CL0177) SBP_bac_11; Bacterial extracellular solute-binding protein (PF13531; HMM-score: 13.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9989
    • Cytoplasmic Membrane Score: 0.0002
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0009
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.03873
    • TAT(Tat/SPI): 0.002447
    • LIPO(Sec/SPII): 0.015072
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MANILLAVTGSIASYKSADLVSSLKKQGHQVTVLMTQAATEFIQPLTLQVLSQNPVHLDVMKEPYPDQVNHIELGKKADLFIVVPATANTIAKLAHGFADNMVTSTALALPSHIPKLIAPAMNTKMYDHPVTQNNLKTLETYGYQLIAPKESLLACGDHGRGALADLTIILERIKETIDEKTL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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