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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_1466 [new locus tag: SPH_RS07090 ]
  • pan locus tag?: PNEUPAN002672000
  • symbol: SPH_1466
  • pan gene symbol?: bglK_1
  • synonym:
  • product: ROK family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_1466 [new locus tag: SPH_RS07090 ]
  • symbol: SPH_1466
  • product: ROK family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1352247..1353137
  • length: 891
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGAAGATTATAGGTATCGATATTGGCGGAACAACAATTAAGGCAGATTTATACGATGAG
    TTTGGAACGAGTTTGAATCATTTCAAAGAGATAGAAACAATTATTGACTATGATTTGGGA
    ACGAATCAGATATTAAATCAGGTCTGTGATTTAATTGGTGAGTATACTTTAAATCATTCA
    ATTGATGGTGTTGGGATTTCCACTGCTGGAGTTGTTAATGCTAATACTGGAGAAATCATC
    TATGCAGGCTATACAATACCAGGGTATATCGGAGTAAACTTTACTGCCGAAATAGAAAAA
    CGTTTTGGGTTGTATACTTTTGTTGAAAATGATGTTAATTGTGCTGCATTAGGTGAATTG
    TGGAAGGGACAAGCCAAAGATAAGAAAAATGTAGTAATGGTTACTATTGGAACAGGTATA
    GGAGGCAGTATTATTGTCAACGGACAAATTGTTAACGGATTTAACTATACTGCTGGTGAA
    GTAGGTTATATTCCTGTAGGTAATTCGGATTGGCAAAGTAAAGCCTCAACAACCGCATTG
    ATTCATTTATATCAAAAAAAGAGCTTGAAAACTAATCAAACTGGACGTACTTTCTTCACT
    GATTTAAGATCTGGAGATAAAGTTGCTGAAGAAACTTTTGAAATTTTTGTAGAAAATCTA
    ACAAAAGGTTTATTAACGATTTCTTATCTACTTAATCCAGAAATTCTCATATTAGGAGGT
    GGGATTCTGGATAGTAAGGATATTTTGTTACCTGAAATTCAAAGTTCTTTAGCTAAAAAT
    GCAATGGATAATAGGTTTTTACCTAAAAATCTTGTGGCAGCTACATTAGGAAATGAAGCT
    GGTCGTATAGGAGCTGTAAAAAATTTCTTAGATAGAATTTCTAATAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    891

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_1466 [new locus tag: SPH_RS07090 ]
  • symbol: SPH_1466
  • description: ROK family protein
  • length: 296
  • theoretical pI: 4.76024
  • theoretical MW: 32058.3
  • GRAVY: 0.022973

⊟Function[edit | edit source]

  • TIGRFAM:
    Unknown function General ROK family protein (putative glucokinase) (TIGR00744; HMM-score: 146.9)
    and 3 more
    Metabolism Energy metabolism Fermentation butyrate kinase (TIGR02707; EC 2.7.2.7; HMM-score: 13.4)
    Metabolism Transport and binding proteins Cations and iron carrying compounds copper transport repressor, CopY/TcrY family (TIGR02698; HMM-score: 13)
    Signal transduction Regulatory functions DNA interactions copper transport repressor, CopY/TcrY family (TIGR02698; HMM-score: 13)
  • TheSEED  :
    • N-acetylmannosamine kinase (EC 2.7.1.60)
    Cell Wall and Capsule Capsular and extracellular polysacchrides Sialic Acid Metabolism  N-acetylmannosamine kinase (EC 2.7.1.60)
  • PFAM:
    Actin_ATPase (CL0108) ROK; ROK family (PF00480; HMM-score: 156.1)
    and 3 more
    HTH (CL0123) Penicillinase_R; Penicillinase repressor (PF03965; HMM-score: 14.3)
    no clan defined Corona_NS12-7; Coronavirus non-structural protein NS12.7 family (PF04753; HMM-score: 12.4)
    Actin_ATPase (CL0108) FGGY_N; FGGY family of carbohydrate kinases, N-terminal domain (PF00370; HMM-score: 11.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008333
    • TAT(Tat/SPI): 0.000096
    • LIPO(Sec/SPII): 0.00078
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKIIGIDIGGTTIKADLYDEFGTSLNHFKEIETIIDYDLGTNQILNQVCDLIGEYTLNHSIDGVGISTAGVVNANTGEIIYAGYTIPGYIGVNFTAEIEKRFGLYTFVENDVNCAALGELWKGQAKDKKNVVMVTIGTGIGGSIIVNGQIVNGFNYTAGEVGYIPVGNSDWQSKASTTALIHLYQKKSLKTNQTGRTFFTDLRSGDKVAEETFEIFVENLTKGLLTISYLLNPEILILGGGILDSKDILLPEIQSSLAKNAMDNRFLPKNLVAATLGNEAGRIGAVKNFLDRISNK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: RpiR* (repression) regulon, NanR* (repression) regulon, CcpA regulon
    RpiR*(TF)important in Sialic acid utilization; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 
    NanR*(TF)important in Sialic acid utilization; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 
    CcpA(TF)important in Global catabolite repression; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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