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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_2342 [new locus tag: SPH_RS11475 ]
  • pan locus tag?: PNEUPAN003828000
  • symbol: arcC
  • pan gene symbol?: arcC
  • synonym:
  • product: carbamate kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_2342 [new locus tag: SPH_RS11475 ]
  • symbol: arcC
  • product: carbamate kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 2149645..2150592
  • length: 948
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGGCAAATCGTAAAATTGTAGTAGCTTTGGGAGGAAATGCGATTCTTTCTTCTGACCCA
    TCAGCAAAGGCTCAACAAGAAGCTTTAGTTGAAACAGCTAAGCATCTTGTAAAATTGATT
    AAAAATGGAGATGATTTGATTATCACTCACGGTAATGGACCTCAAGTTGGGAATCTCTTG
    CTCCAACATTTGGCATCAGACTCTGAAAAGAACCCTGCCTTCCCACTCGACTCACTTGTC
    GCTATGACAGAAGGTAGCATCGGTTTCTGGTTGAAAAATGCTTTGCAAAATGCTCTCTTG
    GATGAAGGCATCGAAAAAAATGTTGCCTCTGTTGTAACGCAAGTTATCGTAGATAAAAAT
    GATCCAGCTTTTGTTAACTTGAGTAAACCAATCGGTCCTTTCTATTCAGAAGAAGAAGCA
    AAAGCAGAAGCCGAAAAGAGCGGAGCGACTTTCAAGGAAGATGCTGGCCGTGGCTGGCGT
    AAGGTCGTTGCCTCACCAAAACCTGTTGACATCAAAGAAATTGAAACCATCCGTACTCTT
    TTAAATAGTGGTCAAGTCGTCGTAGCTGCAGGTGGTGGCGGTATTCCCGTCGTCAAAGAA
    AACAATGGACATTTGACTGGTGTCGAAGCGGTTATTGATAAAGACTTCGCTTCCCAACGT
    TTGGCAGAATTGGTTGATGCAGACCTCTTCATCGTTTTGACAGGTGTAGATTATGTATTT
    GTTAACTACAACAAGCCAAACCAGGAAAAATTGGAACATGTGAATGTTGCCCAGCTGGAA
    GAATATATCAAACAAGATCAGTTTGCACCAGGTAGCATGCTTCCAAAAGTAGAAGCAGCT
    ATCGCTTTTGTCAATGGTCGTCCAGAAGGAAAAGCAGTTATTACTTCCCTTGAAAATCTA
    GGCGCCTTGATTGAATCTGAAAGCGGAACAATTATTGAAAAAGGATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    948

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_2342 [new locus tag: SPH_RS11475 ]
  • symbol: ArcC
  • description: carbamate kinase
  • length: 315
  • theoretical pI: 4.67351
  • theoretical MW: 33623
  • GRAVY: -0.0806349

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.2.2?  ExPASy
    Carbamate kinase ATP + NH3 + CO2 = ADP + carbamoyl phosphate
  • TIGRFAM:
    Metabolism Energy metabolism Amino acids and amines carbamate kinase (TIGR00746; EC 2.7.2.2; HMM-score: 427.9)
    and 4 more
    Metabolism Amino acid biosynthesis Glutamate family acetylglutamate kinase (TIGR00761; EC 2.7.2.8; HMM-score: 41.7)
    Metabolism Amino acid biosynthesis Glutamate family glutamate 5-kinase (TIGR01027; EC 2.7.2.11; HMM-score: 29.2)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions putative uridylate kinase (TIGR02076; EC 2.7.4.-; HMM-score: 25.9)
    Metabolism Amino acid biosynthesis Glutamate family delta l-pyrroline-5-carboxylate synthetase (TIGR01092; HMM-score: 17.7)
  • TheSEED  :
    • Carbamate kinase (EC 2.7.2.2)
    Amino Acids and Derivatives Arginine; urea cycle, polyamines Arginine and Ornithine Degradation  Carbamate kinase (EC 2.7.2.2)
    and 2 more
    Amino Acids and Derivatives Arginine; urea cycle, polyamines Arginine Deiminase Pathway  Carbamate kinase (EC 2.7.2.2)
    Amino Acids and Derivatives Arginine; urea cycle, polyamines Polyamine Metabolism  Carbamate kinase (EC 2.7.2.2)
  • PFAM:
    no clan defined AA_kinase; Amino acid kinase family (PF00696; HMM-score: 106.2)
    and 2 more
    P-loop_NTPase (CL0023) SKI; Shikimate kinase (PF01202; HMM-score: 15.6)
    HTH (CL0123) GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 12.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: Signal peptide SP(Sec/SPI) length 24 aa
    • SP(Sec/SPI): 0.535024
    • TAT(Tat/SPI): 0.026665
    • LIPO(Sec/SPII): 0.010085
    • Cleavage Site: CS pos: 24-25. AKA-QQ. Pr: 0.5272
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MANRKIVVALGGNAILSSDPSAKAQQEALVETAKHLVKLIKNGDDLIITHGNGPQVGNLLLQHLASDSEKNPAFPLDSLVAMTEGSIGFWLKNALQNALLDEGIEKNVASVVTQVIVDKNDPAFVNLSKPIGPFYSEEEAKAEAEKSGATFKEDAGRGWRKVVASPKPVDIKEIETIRTLLNSGQVVVAAGGGGIPVVKENNGHLTGVEAVIDKDFASQRLAELVDADLFIVLTGVDYVFVNYNKPNQEKLEHVNVAQLEEYIKQDQFAPGSMLPKVEAAIAFVNGRPEGKAVITSLENLGALIESESGTIIEKG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: GlnR* (repression) regulon, ArgR2* (activation (repression)) regulon, AhrC* (activation (repression)) regulon, ArgR1* (activation (repression)) regulon
    GlnR*(TF)important in Nitrogen assimilation; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 
    ArgR2*(TF)important in Arginine biosynthesis, Arginine degradation; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 
    AhrC*(TF)important in Arginine biosynthesis, Arginine degradation; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 
    ArgR1*(TF)important in Arginine biosynthesis, Arginine degradation; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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