PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 13-DEC-2020

⊟Summary

• organism: Streptococcus pneumoniae SPN994038
• locus tag: SPN994038_RS10440 [old locus tag: SPN994038_18890 ]
• pan locus tag^?: PNEUPAN003828000
• symbol: arcC
• pan gene symbol^?: arcC
• synonym:
• product: carbamate kinase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPN994038_RS10440 [old locus tag: SPN994038_18890 ]
• symbol: arcC
• product: carbamate kinase
• replicon: chromosome
• strand: +
• coordinates: 1929989..1930936
• length: 948
• essential: unknown

⊟Accession numbers

• Location: NC_021026 (1929989..1930936) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1977 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  
  ATGGCAAATCGTAAAATTGTAGTAGCTTTGGGAGGAAATGCGATTCTTTCTTCTGACCCA
  TCAGCAAAGGCTCAACAAGAAGCTTTAGTTGAAACAGCTAAGCATCTTGTAAAATTGATT
  AAAAATGGAGATGATTTGATTATCACTCACGGTAATGGACCTCAAGTTGGGAATCTCTTG
  CTCCAACATTTGGCATCAGACTCTGAAAAGAACCCTGCCTTCCCACTCGACTCACTTGTC
  GCTATGACAGAAGGTAGCATCGGTTTCTGGTTGAAAAATGCTTTGCAAAATGCTCTCTTG
  GATGAAGGCATCGAAAAAAATGTTGCCTCTGTTGTAACGCAAGTTGTCGTAGATAAAAAT
  GATCCAGCTTTTGTTAACTTGAGTAAACCAATCGGTCCTTTCTATTCAGAAGAAGAAGCA
  AAAGCAGAAGCCGAAAAGAGCGGAGCGACTTTCAAGGAAGATGCTGGCCGTGGCTGGCGT
  AAGGTCGTTGCCTCACCAAAACCTGTTGACATCAAAGAAATTGAAACCATCCGTACTCTT
  TTAAATAATGGTCAAGTCGTCGTAGCTGCAGGTGGTGGCGGTATTCCCGTCGTCAAAGAA
  AACAATGGACATTTGACTGGTGTCGAAGCGGTTATTGATAAAGACTTCGCTTCCCAACGT
  TTGGCAGAATTGGTTGATGCAGACCTCTTCATCGTTTTGACAGGTGTAGATTATGTATTT
  GTTAACTACAACAAGCCAAACCAGGAAAAATTGGAACATGTGAATGTTGCCCAGCTGGAA
  GAATATATCAAACAAGATCAGTTTGCACCAGGTAGCATGCTTCCAAAAGTAGAAGCAGCT
  ATCGCTTTTGTCAATGGTCGTCCAGAAGGAAAAGCAGTTATTACTTCCCTTGAAAATCTA
  GGCGCCTTGATTGAATCTGAAAGTGGAACAATTATTGAAAAAGGATAA
  60
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  420
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  720
  780
  840
  900
  948
  

⊟Protein

⊟General

• locus tag: SPN994038_RS10440 [old locus tag: SPN994038_18890 ]
• symbol: ArcC
• description: carbamate kinase
• length: 315
• theoretical pI: 4.67351
• theoretical MW: 33636
• GRAVY: -0.0901587

⊟Function

• reaction:
  EC 2.7.2.2?  ExPASy
  Carbamate kinase ATP + NH₃ + CO₂ = ADP + carbamoyl phosphate
• TIGRFAM:
  Metabolism Energy metabolism Amino acids and amines carbamate kinase (TIGR00746; EC 2.7.2.2; HMM-score: 428.3)
  and 4 more
  Metabolism Amino acid biosynthesis Glutamate family acetylglutamate kinase (TIGR00761; EC 2.7.2.8; HMM-score: 41.1)
  Metabolism Amino acid biosynthesis Glutamate family glutamate 5-kinase (TIGR01027; EC 2.7.2.11; HMM-score: 29.1)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions putative uridylate kinase (TIGR02076; EC 2.7.4.-; HMM-score: 26.1)
  Metabolism Amino acid biosynthesis Glutamate family delta l-pyrroline-5-carboxylate synthetase (TIGR01092; HMM-score: 17.6)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  no clan defined AA_kinase; Amino acid kinase family (PF00696; HMM-score: 108.2)
  and 2 more
  P-loop_NTPase (CL0023) SKI; Shikimate kinase (PF01202; HMM-score: 15.6)
  HTH (CL0123) GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 12.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• SignalP: Signal peptide SP(Sec/SPI) length 24 aa
  • SP(Sec/SPI): 0.535024
  • TAT(Tat/SPI): 0.026665
  • LIPO(Sec/SPII): 0.010085
  • Cleavage Site: CS pos: 24-25. AKA-QQ. Pr: 0.5272
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000013420 NCBI
• UniProt:

⊟Protein sequence

• MANRKIVVALGGNAILSSDPSAKAQQEALVETAKHLVKLIKNGDDLIITHGNGPQVGNLLLQHLASDSEKNPAFPLDSLVAMTEGSIGFWLKNALQNALLDEGIEKNVASVVTQVVVDKNDPAFVNLSKPIGPFYSEEEAKAEAEKSGATFKEDAGRGWRKVVASPKPVDIKEIETIRTLLNNGQVVVAAGGGGIPVVKENNGHLTGVEAVIDKDFASQRLAELVDADLFIVLTGVDYVFVNYNKPNQEKLEHVNVAQLEEYIKQDQFAPGSMLPKVEAAIAFVNGRPEGKAVITSLENLGALIESESGTIIEKG

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_1977 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications