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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 10-MAR-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS00560 [old locus tag: SPH_0119 ]
  • pan locus tag?: PNEUPAN000439000
  • symbol: SPH_RS00560
  • pan gene symbol?: —
  • synonym:
  • product: phage holin

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS00560 [old locus tag: SPH_0119 ]
  • symbol: SPH_RS00560
  • product: phage holin
  • replicon: chromosome
  • strand: +
  • coordinates: 97722..98054
  • length: 333
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (97722..98054) NCBI
  • BioCyc: SPH_RS00560 BioCyc
  • MicrobesOnline: see SPH_0119
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    ATGCAACAAATTACTGAAATCATTACTAATGGAGCAATCAGCATCCTAGTCGTTTTGGCA
    GGGGTTGTAGTTAGGGCAGTCAAGGACTACCTGGTTCAAAAAGGTGGAGAAAAGACCATC
    AAGATTGTTGAAATCTTGGCCAAAAATGCAGTAAATGCCGTGGAGCAGGTAGCTGCTGAA
    ACTGGCTACAAGGGAGATGAAAAACTGGCACAGGCTCGCGCTAAAGTCCGTGCTGAGCTT
    ACAAAATACAATATTAGTATGACTGACAAAGACTTAGACACCTTCGTAGAGTCAGCAGTG
    AAGCAGATGAATGACGCATGGAAAGGACGATAG
    60
    120
    180
    240
    300
    333

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS00560 [old locus tag: SPH_0119 ]
  • symbol: SPH_RS00560
  • description: phage holin
  • length: 110
  • theoretical pI: 9.47367
  • theoretical MW: 12021.9
  • GRAVY: -0.0690909

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Mobile and extrachromosomal element functions Prophage functions phage holin, LL-H family (TIGR01673; HMM-score: 54.2)
  • TheSEED: see SPH_0119
  • PFAM:
    no clan defined Phage_holin_6_1; Bacteriophage holin of superfamily 6 (Holin_LLH) (PF09682; HMM-score: 94.8)
    and 2 more
    ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4 (PF12896; HMM-score: 11.9)
    Oxa1 (CL0376) EMC3_TMCO1; Integral membrane protein EMC3/TMCO1-like (PF01956; HMM-score: 11.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.257893
    • TAT(Tat/SPI): 0.002598
    • LIPO(Sec/SPII): 0.009073
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MQQITEIITNGAISILVVLAGVVVRAVKDYLVQKGGEKTIKIVEILAKNAVNAVEQVAAETGYKGDEKLAQARAKVRAELTKYNISMTDKDLDTFVESAVKQMNDAWKGR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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