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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS02720 [old locus tag: SPH_0560 ]
  • pan locus tag?: PNEUPAN001300000
  • symbol: SPH_RS02720
  • pan gene symbol?: glnHP1
  • synonym:
  • product: ABC transporter substrate-binding protein/permease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS02720 [old locus tag: SPH_0560 ]
  • symbol: SPH_RS02720
  • product: ABC transporter substrate-binding protein/permease
  • replicon: chromosome
  • strand: -
  • coordinates: 505831..507396
  • length: 1566
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    ATGAGAAAAATATACTTATCTATTTTCACAAGTCTCTTGCTGATGCTAGGACTTGTCAAT
    GTTGCTCAAGCCGATGAATATTTACGCATCGGGATGGAAGCAGCATATGCTCCCTTTAAC
    TGGACCCAGGATGATGATAGCAACGGAGCTGTCAAAATCGATGGGACCAATCAGTATGCC
    AACGGATACGATGTTCAAATCGCCAAGAAAATCGCTAAGGACTTAGGTAAAGAACCTTTG
    GTTGTTAAAACCAAGTGGGAAGGTCTAGTCCCTGCCCTTACTTCTGGTAAGATTGACATG
    ATTATCGCAGGTATGAGTCCAACTGCAGAACGCAAACAAGAAATTGCCTTTTCGAGCAGT
    TACTACACTAGCGAACCAGTTTTGCTTGTCAAAAAAGATTCTGCCTACGCAAGTGCTAAA
    TCTTTGGATGACTTTAACGGTGCAAAAATCACTTCTCAACAAGGGGTCTACCTCTACGAC
    TTGATTGCACAAATCCCAGGTGCTAAAAAAGAAACAGCCATGGGAGACTTCGCTCAAATG
    CGCCAAGCTCTTGAGGCTGGTGTCATTGATGCTTATGTTTCTGAACGTCCAGAAGCACTG
    ACTGCTGAAGCTGCGAACTCTAAGTTCAAGATGATTCAAGTAGAACCTGGTTTCAAAACT
    GGGGAAGAAGATACAGCTATCGCTATCGGGCTTCGTAAAAATGACAATCGTATTAGCCAA
    ATCAATGCCAGCATTGAAACCATTTCAAAAGATGACCAAGTTGCCTTGATGGATCGTATG
    ATCAAGGAACAACCTGCCGAAGCTACAACAACTGAAGAGACTAGCAGTAGTTTCTTTAGC
    CAAGTCGCTAAAATTCTTTCTGAAAACTGGCAACAACTCTTGCGTGGTGCTGGTATCACT
    CTTTTAATCTCTATCGTCGGAACCATCATAGGTCTCATTATTGGACTTGCCATTGGTGTC
    TTCCGTACTGCTCCTCTCTCTGAAAACAAAGCCATTTATGGCCTTCAAAAACTAGTCGGC
    TGGGTTCTCAATGTCTACATTGAAATTTTCCGTGGTACGCCAATGATTGTTCAATCGATG
    GTTATCTACTATGGAACTGCCCAAGCTTTCGGGATCAACCTTGACCGTACACTAGCTGCT
    ATCTTCATCGTTTCAATCAATACCGGTGCCTACATGACTGAAATCGTCCGTGGTGGTATC
    CTAGCAGTTGACAAGGGACAATTTGAAGCTGCGACTGCTCTTGGTATGACCCATAACCAG
    ACCATGCGTAAGATTGTCCTACCTCAGGTAGTCCGTAACATCCTACCTGCAACTGGTAAT
    GAATTTGTCATCAATATCAAAGATACATCTGTATTGAACGTTATCTCTGTTGTCGAACTT
    TATTTCTCAGGAAATACCGTGGCAACACAAACCTATCAATACTTCCAGACATTTACAATC
    ATTGCCGTGATTTACTTTGTCCTCACCTTCACCGTAACACGTATCCTACGCTTTATCGAG
    CGCAGAATGGACATGGATACCTACACTACAGGTGCTAACCAAATGCAAACGGAGGATTTG
    AAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1566

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS02720 [old locus tag: SPH_0560 ]
  • symbol: SPH_RS02720
  • description: ABC transporter substrate-binding protein/permease
  • length: 521
  • theoretical pI: 5.0084
  • theoretical MW: 57358.7
  • GRAVY: 0.0965451

⊟Function[edit | edit source]

  • TIGRFAM:
    ectoine/hydroxyectoine ABC transporter, permease protein EhuD (TIGR03003; HMM-score: 143.4)
    ectoine/hydroxyectoine ABC transporter, permease protein EhuC (TIGR03004; HMM-score: 142.6)
    and 11 more
    Metabolism Transport and binding proteins Amino acids, peptides and amines lysine-arginine-ornithine-binding periplasmic protein (TIGR01096; HMM-score: 107.3)
    Metabolism Transport and binding proteins Amino acids, peptides and amines amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family (TIGR01726; HMM-score: 74.6)
    Metabolism Transport and binding proteins Anions phosphonate ABC transporter, permease protein PhnE (TIGR01097; HMM-score: 49.7)
    Metabolism Transport and binding proteins Amino acids, peptides and amines ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB (TIGR02995; HMM-score: 36.1)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, permease protein PstA (TIGR00974; HMM-score: 25.6)
    quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein (TIGR03871; HMM-score: 24.8)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, permease protein PstC (TIGR02138; HMM-score: 21.4)
    NifC-like ABC-type porter (TIGR01581; HMM-score: 16.5)
    Metabolism Transport and binding proteins Anions molybdate ABC transporter, permease protein (TIGR02141; HMM-score: 16.4)
    choline ABC transporter, permease protein (TIGR03416; HMM-score: 14.9)
    2-aminoethylphosphonate ABC transporter, permease protein (TIGR03226; HMM-score: 13.2)
  • TheSEED: see SPH_0560
  • PFAM:
    PBP (CL0177) SBP_bac_3; Bacterial extracellular solute-binding proteins, family 3 (PF00497; HMM-score: 125.9)
    and 3 more
    BPD_transp_1 (CL0404) BPD_transp_1; Binding-protein-dependent transport system inner membrane component (PF00528; HMM-score: 71.7)
    PBP (CL0177) Lig_chan-Glu_bd; Ligated ion channel L-glutamate- and glycine-binding site (PF10613; HMM-score: 34.4)
    SBP_bac_1; Bacterial extracellular solute-binding protein (PF01547; HMM-score: 18.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.01
    • Cytoplasmic Membrane Score: 9.99
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 2
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9997
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0002
  • SignalP: Signal peptide SP(Sec/SPI) length 24 aa
    • SP(Sec/SPI): 0.997105
    • TAT(Tat/SPI): 0.000301
    • LIPO(Sec/SPII): 0.001824
    • Cleavage Site: CS pos: 24-25. AQA-DE. Pr: 0.9790
  • predicted transmembrane helices (TMHMM): 6

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MRKIYLSIFTSLLLMLGLVNVAQADEYLRIGMEAAYAPFNWTQDDDSNGAVKIDGTNQYANGYDVQIAKKIAKDLGKEPLVVKTKWEGLVPALTSGKIDMIIAGMSPTAERKQEIAFSSSYYTSEPVLLVKKDSAYASAKSLDDFNGAKITSQQGVYLYDLIAQIPGAKKETAMGDFAQMRQALEAGVIDAYVSERPEALTAEAANSKFKMIQVEPGFKTGEEDTAIAIGLRKNDNRISQINASIETISKDDQVALMDRMIKEQPAEATTTEETSSSFFSQVAKILSENWQQLLRGAGITLLISIVGTIIGLIIGLAIGVFRTAPLSENKAIYGLQKLVGWVLNVYIEIFRGTPMIVQSMVIYYGTAQAFGINLDRTLAAIFIVSINTGAYMTEIVRGGILAVDKGQFEAATALGMTHNQTMRKIVLPQVVRNILPATGNEFVINIKDTSVLNVISVVELYFSGNTVATQTYQYFQTFTIIAVIYFVLTFTVTRILRFIERRMDMDTYTTGANQMQTEDLK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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