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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 24-APR-2025
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae Hungary19A-6
- locus tag: SPH_RS04195 [old locus tag: SPH_0869 ]
- pan locus tag?: PNEUPAN001711000
- symbol: SPH_RS04195
- pan gene symbol?: ABC-NBD_5
- synonym:
- product: ABC-F family ATP-binding cassette domain-containing protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPH_RS04195 [old locus tag: SPH_0869 ]
- symbol: SPH_RS04195
- product: ABC-F family ATP-binding cassette domain-containing protein
- replicon: chromosome
- strand: +
- coordinates: 807030..808571
- length: 1542
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NC_010380 (807030..808571) NCBI
- BioCyc: SPH_RS04195 BioCyc
- MicrobesOnline: see SPH_0869
- PneumoBrowse for strain D39V: SPV_0671 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1501ATGAGTATTTTAGAAGTTAAAAATCTGAGTCACGGTTTTGGTGACCGTGCAATTTTTGAA
GATGTGTCCTTCCGTCTCCTCAAGGGAGAACATATCGGCCTGGTCGGTGCCAATGGTGAA
GGAAAATCAACCTTTATGAGTATCGTGACTGGTAAAATGCTGCCAGATGAAGGAAAGGTT
GAGTGGTCCAAATATGTGACGGCTGGTTACTTGGATCAGCACTCTGTCCTTACTGAAAGA
CAGTCGGTGCGTGATGTTCTCCGTACGGCTTTTGATGAGCTTTTCAAAGCTGAAGCTCGT
ATCAATGACCTCTATATGGAAATGGCTGAAGACGGTGCGGATGTTGATGCTCTCATGGAA
GAAGTGGGAGAACTTCAAGACCGTCTGGAGAGTCGTGATTTCTATATCTTGGATGCTAAG
ATTGACGAAGTAGCGCGTGCTCTTGGTATTATGGACTTTGGCATGGATACGGATGTAACT
TCTTTGTCAGGTGGGCAAAGAACCAAGGTGCTTTTGGCAAAACTTCTCCTTGAAAAGCCT
GATATTTTGCTGTTGGACGAGCCGACCAACTACTTGGATGCTGAGCATATTGATTGGCTC
AAGCGCTATCTCCAAAACTATGAGAATGCCTTTGTTCTCATTTCGCACGATATTCCATTC
CTCAATGACGTTATCAATATTGTCTATCATGTGGAAAATCAACAGCTGACGCGTTACTCT
GGTGACTACTACCAGTTCCAAGAAGTTTATGCTATGAAGAAATCTCAGCTAGAGGCAGCC
TACGAACGCCAGCAGAAAGAGATTGCAGACCTCAAGGACTTTGTGGCTCGTAATAAAGCC
CGTGTTGCAACTCGTAATATGGCTATGTCTCGTCAAAAGAAATTGGATAAGATGGATATT
ATCGAACTCCAAAGTGAGAAACCAAAACCATCCTTTGATTTCAAACCAGCTCGTACACCA
GGGCGCTTTATCTTCCAAGCCAAGAACTTGCAAATTGGTTACGACCGTCCTCTTACTAAG
CCTTTAAATCTTACCTTCGAACGCAATCAAAAGGTTGCGATTATTGGTGCTAATGGTATT
GGAAAAACAACTCTCTTGAAGAGTCTCTTGGGCATTATCTCGCCAATCGCTGGGGAAGTG
GAGCGTGGAGATTATTTAGAACTTGGTTATTTTGAGCAGGAAGTAGAAGGCGGTAATCGC
CAAACTCCTCTTGAAGCTGTCTGGAATGCCTTTCCTGCCCTTAATCAAGCAGAAGTCCGT
GCAGCCCTTGCCCGTTGTGGTTTGACAACCAAACATATTGAAAGCCAGATTCAAGTATTA
TCAGGGGGAGAGCAAGCCAAGGTTCGTTTCTGTCTCTTGATGAATCGTGAAAACAACGTT
TTAGTGCTGGACGAGCCGACCAACCATTTGGATGTGGATGCAAAGGATGAGCTCAAACGC
GCTCTCAAAGAATACAGGGGATCTATCCTTATGGTCTGCCACGAGCCAGACTTTTATGAA
GGTTGGATAGACCAAATATGGGATTTTAATAATTTAACTTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPH_RS04195 [old locus tag: SPH_0869 ]
- symbol: SPH_RS04195
- description: ABC-F family ATP-binding cassette domain-containing protein
- length: 513
- theoretical pI: 4.81965
- theoretical MW: 58454.2
- GRAVY: -0.35614
⊟Function[edit | edit source]
- TIGRFAM: ATP-binding cassette protein, ChvD family (TIGR03719; HMM-score: 331.5)and 87 morethiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 152.7)Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 149.1)thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 140.5)Transport and binding proteins Cations and iron carrying compounds cobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 140.2)Cellular processes Pathogenesis type I secretion system ATPase (TIGR03375; HMM-score: 139)Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR03375; HMM-score: 139)Protein fate Protein and peptide secretion and trafficking heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 137.3)Transport and binding proteins Other heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 137.3)proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 136.3)Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 130.8)Cellular processes Toxin production and resistance putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 121.6)Transport and binding proteins Unknown substrate putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 121.6)Transport and binding proteins Carbohydrates, organic alcohols, and acids ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system (TIGR03864; HMM-score: 119.1)Cellular processes Cell division cell division ATP-binding protein FtsE (TIGR02673; HMM-score: 112)Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtD (TIGR03411; HMM-score: 111.3)Transport and binding proteins Anions phosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 110.4)Transport and binding proteins Other thiamine ABC transporter, ATP-binding protein (TIGR01277; EC 3.6.3.-; HMM-score: 109.3)Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 107.3)Transport and binding proteins Other daunorubicin resistance ABC transporter, ATP-binding protein (TIGR01188; HMM-score: 106.4)Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 106.4)Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 106.4)lantibiotic protection ABC transporter, ATP-binding subunit (TIGR03740; HMM-score: 105.5)Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtE (TIGR03410; HMM-score: 105)Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 101.8)Transport and binding proteins Other LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 101.8)Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 100.5)Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01842; HMM-score: 100.4)gliding motility-associated ABC transporter ATP-binding subunit GldA (TIGR03522; HMM-score: 98.5)Transport and binding proteins Unknown substrate anchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 98.5)Transport and binding proteins Anions sulfate ABC transporter, ATP-binding protein (TIGR00968; EC 3.6.3.25; HMM-score: 98)Energy metabolism Methanogenesis methyl coenzyme M reductase system, component A2 (TIGR03269; HMM-score: 96.1)Transport and binding proteins Carbohydrates, organic alcohols, and acids D-xylose ABC transporter, ATP-binding protein (TIGR02633; EC 3.6.3.17; HMM-score: 94.3)Transport and binding proteins Amino acids, peptides and amines putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein (TIGR03265; HMM-score: 93.5)Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikE (TIGR02769; EC 3.6.3.24; HMM-score: 93.1)Cellular processes Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 91.6)Transport and binding proteins Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 91.6)Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 90.4)Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 90.4)ABC exporter ATP-binding subunit, DevA family (TIGR02982; HMM-score: 85.5)Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly ATPase SufC (TIGR01978; HMM-score: 84.9)Transport and binding proteins Anions molybdate ABC transporter, ATP-binding protein (TIGR02142; EC 3.6.3.29; HMM-score: 84.7)Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 83.7)ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 82.9)phosphonate C-P lyase system protein PhnL (TIGR02324; HMM-score: 82.2)2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT (TIGR03258; HMM-score: 79.5)Transport and binding proteins Anions nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 76.8)Transport and binding proteins Other nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 76.8)ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA (TIGR03005; HMM-score: 74)Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikD (TIGR02770; HMM-score: 73.9)Protein fate Protein and peptide secretion and trafficking ABC-type bacteriocin transporter (TIGR01193; HMM-score: 72.7)Protein fate Protein modification and repair ABC-type bacteriocin transporter (TIGR01193; HMM-score: 72.7)Transport and binding proteins Other ABC-type bacteriocin transporter (TIGR01193; HMM-score: 72.7)Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 72.6)Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 72.6)Transport and binding proteins Other pigment precursor permease (TIGR00955; HMM-score: 69.4)Transport and binding proteins Amino acids, peptides and amines polyamine ABC transporter, ATP-binding protein (TIGR01187; EC 3.6.3.31; HMM-score: 67.8)Transport and binding proteins Carbohydrates, organic alcohols, and acids peroxysomal long chain fatty acyl transporter (TIGR00954; HMM-score: 66.8)Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 65.6)D-methionine ABC transporter, ATP-binding protein (TIGR02314; EC 3.6.3.-; HMM-score: 65.4)Transport and binding proteins Amino acids, peptides and amines glycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 64.3)Central intermediary metabolism Phosphorus compounds phosphonate C-P lyase system protein PhnK (TIGR02323; HMM-score: 62.6)Transport and binding proteins Carbohydrates, organic alcohols, and acids glucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 60.6)Transport and binding proteins Anions cystic fibrosis transmembrane conductor regulator (CFTR) (TIGR01271; EC 3.6.3.49; HMM-score: 60.3)Transport and binding proteins Other rim ABC transporter (TIGR01257; HMM-score: 51.8)Transport and binding proteins Amino acids, peptides and amines cyclic peptide transporter (TIGR01194; HMM-score: 46.9)Transport and binding proteins Other cyclic peptide transporter (TIGR01194; HMM-score: 46.9)Transport and binding proteins Amino acids, peptides and amines choline ABC transporter, ATP-binding protein (TIGR03415; HMM-score: 42.9)Transport and binding proteins Other multi drug resistance-associated protein (MRP) (TIGR00957; HMM-score: 33)DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit A (TIGR00630; EC 3.1.25.-; HMM-score: 27.1)Transport and binding proteins Other pleiotropic drug resistance family protein (TIGR00956; HMM-score: 25.7)Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 18.6)type IV secretion/conjugal transfer ATPase, VirB4 family (TIGR00929; HMM-score: 17.7)P-type DNA transfer ATPase VirB11 (TIGR02788; HMM-score: 16.5)Protein fate Protein and peptide secretion and trafficking type VII secretion protein EccCb (TIGR03925; HMM-score: 15.3)Cellular processes Chemotaxis and motility flagellar protein export ATPase FliI (TIGR03496; EC 3.6.3.14; HMM-score: 15.1)helicase/secretion neighborhood ATPase (TIGR03819; HMM-score: 14.4)Cellular processes Pathogenesis type III secretion apparatus H+-transporting two-sector ATPase (TIGR02546; EC 3.6.3.14; HMM-score: 12.3)Protein fate Protein and peptide secretion and trafficking type III secretion apparatus H+-transporting two-sector ATPase (TIGR02546; EC 3.6.3.14; HMM-score: 12.3)Transport and binding proteins Amino acids, peptides and amines LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 12.1)Regulatory functions Protein interactions LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 12.1)DNA metabolism DNA replication, recombination, and repair DNA replication and repair protein RecF (TIGR00611; HMM-score: 11.8)restriction system-associated AAA family ATPase (TIGR04435; HMM-score: 11.7)SH3 domain protein (TIGR04211; HMM-score: 10.7)Protein synthesis Other GTP-binding protein Era (TIGR00436; HMM-score: 10.6)DNA metabolism Restriction/modification DNA sulfur modification protein DndD (TIGR03185; HMM-score: 8.4)Protein synthesis Other Obg family GTPase CgtA (TIGR02729; HMM-score: 7.4)Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 7.3)
- TheSEED: see SPH_0869
- PFAM: P-loop_NTPase (CL0023) ABC_tran; ABC transporter (PF00005; HMM-score: 160.5)and 42 moreABC_tran_Xtn; ABC transporter (PF12848; HMM-score: 73.4)AAA_21; AAA domain, putative AbiEii toxin, Type IV TA system (PF13304; HMM-score: 50.5)SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 43.2)AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 26.7)AAA_16; AAA ATPase domain (PF13191; HMM-score: 24.1)MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 21.5)AAA_28; AAA domain (PF13521; HMM-score: 20.8)RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 20.1)AAA_14; AAA domain (PF13173; HMM-score: 20.1)MukB; MukB N-terminal (PF04310; HMM-score: 19.9)AAA_24; AAA domain (PF13479; HMM-score: 19.9)AAA_23; AAA domain (PF13476; HMM-score: 19.2)NACHT; NACHT domain (PF05729; HMM-score: 18.7)RNA_helicase; RNA helicase (PF00910; HMM-score: 17.9)FtsK_SpoIIIE; FtsK/SpoIIIE family (PF01580; HMM-score: 16.5)NB-ARC; NB-ARC domain (PF00931; HMM-score: 15.9)AAA_33; AAA domain (PF13671; HMM-score: 15.8)ATP-synt_ab; ATP synthase alpha/beta family, nucleotide-binding domain (PF00006; HMM-score: 15.1)TrwB_AAD_bind; Type IV secretion-system coupling protein DNA-binding domain (PF10412; HMM-score: 15)Dynamin_N; Dynamin family (PF00350; HMM-score: 14.4)Mg_chelatase; Magnesium chelatase, subunit ChlI (PF01078; HMM-score: 14.1)AAA_25; AAA domain (PF13481; HMM-score: 14)DUF5906; Family of unknown function (DUF5906) (PF19263; HMM-score: 13.7)MeaB; Methylmalonyl Co-A mutase-associated GTPase MeaB (PF03308; HMM-score: 13.5)AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 13.5)AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 13.4)AAA_30; AAA domain (PF13604; HMM-score: 13.3)no clan defined SlyX; SlyX (PF04102; HMM-score: 13)P-loop_NTPase (CL0023) Septin; Septin (PF00735; HMM-score: 12.9)Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 12.8)DUF87; Helicase HerA, central domain (PF01935; HMM-score: 12.4)MobB; Molybdopterin guanine dinucleotide synthesis protein B (PF03205; HMM-score: 12.3)AAA_22; AAA domain (PF13401; HMM-score: 12.1)Ploopntkinase3; P-loop Nucleotide Kinase3 (PF18751; HMM-score: 11.8)AAA_15; AAA ATPase domain (PF13175; HMM-score: 11.6)TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 11.5)Pox_A32; Poxvirus A32 protein (PF04665; HMM-score: 11.4)AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 11.3)AAA_18; AAA domain (PF13238; HMM-score: 11.2)SRP54; SRP54-type protein, GTPase domain (PF00448; HMM-score: 9.2)DO-GTPase2; Double-GTPase 2 (PF19993; HMM-score: 8.9)no clan defined ABC_tran_CTD; ABC transporter C-terminal domain (PF16326; HMM-score: 7.2)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9816
- Cytoplasmic Membrane Score: 0.0085
- Cell wall & surface Score: 0.0003
- Extracellular Score: 0.0097
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.022822
- TAT(Tat/SPI): 0.001159
- LIPO(Sec/SPII): 0.000596
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MSILEVKNLSHGFGDRAIFEDVSFRLLKGEHIGLVGANGEGKSTFMSIVTGKMLPDEGKVEWSKYVTAGYLDQHSVLTERQSVRDVLRTAFDELFKAEARINDLYMEMAEDGADVDALMEEVGELQDRLESRDFYILDAKIDEVARALGIMDFGMDTDVTSLSGGQRTKVLLAKLLLEKPDILLLDEPTNYLDAEHIDWLKRYLQNYENAFVLISHDIPFLNDVINIVYHVENQQLTRYSGDYYQFQEVYAMKKSQLEAAYERQQKEIADLKDFVARNKARVATRNMAMSRQKKLDKMDIIELQSEKPKPSFDFKPARTPGRFIFQAKNLQIGYDRPLTKPLNLTFERNQKVAIIGANGIGKTTLLKSLLGIISPIAGEVERGDYLELGYFEQEVEGGNRQTPLEAVWNAFPALNQAEVRAALARCGLTTKHIESQIQVLSGGEQAKVRFCLLMNRENNVLVLDEPTNHLDVDAKDELKRALKEYRGSILMVCHEPDFYEGWIDQIWDFNNLT
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0671 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]