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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 10-MAR-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS05185 [old locus tag: SPH_1071 ]
  • pan locus tag?: PNEUPAN001997000
  • symbol: mutM
  • pan gene symbol?: mutM
  • synonym:
  • product: DNA-formamidopyrimidine glycosylase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS05185 [old locus tag: SPH_1071 ]
  • symbol: mutM
  • product: DNA-formamidopyrimidine glycosylase
  • replicon: chromosome
  • strand: +
  • coordinates: 987941..988765
  • length: 825
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGCCTGAATTACCTGAGGTTGAAACCGTTTGTCGTGGCTTAGAAAAATTGATTATAGGA
    AAGAAGATTTCGAGTATAGAAATTCGCTACCCCAAGATGATTAAGACGGATTTGGAAGAG
    TTTCAAAGGGAATTGCCTAGTCAGATTATCGAGTCAATGGGACGTCGTGGAAAATATTTG
    CTTTTTTATCTGACAGACAAGGTCTTGATTTCCCATTTGCGGATGGAGGGCAAGTATTTT
    TACTATCCAGACCAAGGACCTGAACGCAAGCATGCCCATGTTTTCTTTCATTTTGAAGAT
    GGTGGCACGCTTGTTTATGAGGATGTTCGCAAGTTTGGAACCATGGAACTCTTGGTGCCT
    GACCTTTTAGACGCCTACTTTATTTCTAAAAAATTAGGTCCTGAACCAAGCGAACAAGAC
    TTTGATTTACAGGTCTTTCAATCTGCCCTTGCCAAGTCCAAAAAGCCTATCAAATCCCAT
    CTCCTAGACCAGACCTTGGTAGCTGGACTTGGCAATATCTATGTGGATGAGGTTCTCTGG
    CGAGCTCAGGTTCATCCAGCTAGATCTTCCCAGACTTTGACAGCAGAAGAAGCGACAGCT
    ATTCATGACCAAACCATTGCTGTTTTGAGCCAGGCTGTTGAAAAAGGCGGTTCCACCATT
    CGGACCTATACCAATGCCTTTGGGGAAGATGGAAGCATGCAGGATTTTCATCAGGTCTAT
    GATAAGACTGGTCAAGAATGTGTACGCTGTGGTACCATCATTGAGAAAATTCAACTAGGC
    GGACGAAGCACCCACTTTTGTCCAAACTGTCAAAGGAGGGACTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    825

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS05185 [old locus tag: SPH_1071 ]
  • symbol: MutM
  • description: DNA-formamidopyrimidine glycosylase
  • length: 274
  • theoretical pI: 6.42382
  • theoretical MW: 31237.5
  • GRAVY: -0.398175

⊟Function[edit | edit source]

  • reaction:
    EC 3.2.2.23?  ExPASy
    DNA-formamidopyrimidine glycosylase Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine
  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA-formamidopyrimidine glycosylase (TIGR00577; EC 3.2.2.23; HMM-score: 346)
  • TheSEED: see SPH_1071
  • PFAM:
    H2TH (CL0303) H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain (PF06831; HMM-score: 113.6)
    no clan defined Fapy_DNA_glyco; Formamidopyrimidine-DNA glycosylase N-terminal domain (PF01149; HMM-score: 113.5)
    and 5 more
    Zn_Beta_Ribbon (CL0167) zf-FPG_IleRS; Zinc finger found in FPG and IleRS (PF06827; HMM-score: 45.1)
    H2TH (CL0303) NFACT_N; NFACT N-terminal and middle domains (PF05833; HMM-score: 23.5)
    Zn_Beta_Ribbon (CL0167) Zn-ribbon_8; Zinc ribbon domain (PF09723; HMM-score: 15.3)
    OrfB_Zn_ribbon; Putative transposase DNA-binding domain (PF07282; HMM-score: 14.7)
    no clan defined RNHCP; RNHCP domain (PF12647; HMM-score: 12.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001497
    • TAT(Tat/SPI): 0.000149
    • LIPO(Sec/SPII): 0.000302
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRELPSQIIESMGRRGKYLLFYLTDKVLISHLRMEGKYFYYPDQGPERKHAHVFFHFEDGGTLVYEDVRKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQSALAKSKKPIKSHLLDQTLVAGLGNIYVDEVLWRAQVHPARSSQTLTAEEATAIHDQTIAVLSQAVEKGGSTIRTYTNAFGEDGSMQDFHQVYDKTGQECVRCGTIIEKIQLGGRSTHFCPNCQRRD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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